Role of Epigenetically Active Environmental Compounds in Neurodevelopmental Disorders
表观遗传活性环境化合物在神经发育障碍中的作用
基本信息
- 批准号:10271253
- 负责人:
- 金额:$ 24.38万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-25 至 2022-08-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalASD patientATAC-seqAddressAffectAntidotesAromatic Polycyclic HydrocarbonsBioinformaticsBiologicalBiological AssayBiological ProcessBrainCase StudyCell DeathCell LineCellsChIP-seqChemicalsCollectionDataData SetDecision MakingDevelopmentEnvironmentEpigenetic ProcessExposure toFetal DevelopmentFlowchartsFrequenciesFutureGenotypeGoalsGuidelinesHumanHuman DevelopmentHuman bodyIn VitroIndividualLaboratoriesLibrariesLinkMachine LearningNeuritesNeurodevelopmental DisorderNeuronal DifferentiationNeuronsPatientsPatternPhasePlant RootsProcessProtective AgentsRegulationRiskRoleServicesTechniquesTestingThalidomideToxic effectToxicity TestsToxicologyValidationValproic AcidVertebratesadverse outcomeautism spectrum disorderbasebisphenol Acell growthcost effectivecytotoxicitydashboardenvironmental chemicalepigenomeexperimental studyhigh throughput screeninghistone modificationhuman modelin vivoinduced pluripotent stem cellinsightmicroscopic imagingnerve stem cellneurodevelopmentnovelnovel strategiesphthalatesprogenitorrelating to nervous systemscreeningself-renewalsmall molecule librariesstemstem cell fatestem cell modelsynaptogenesistooltranscriptome sequencing
项目摘要
PROJECT SUMMARY
Neurodevelopmental disorders (NDDs), are increasingly recognized as originating from dysregulation of
early brain development, which represents a window of vulnerability to environmental compounds.
Environmental compounds may alter neurodevelopment via epigenetic mechanisms, which may not induce
massive cell death, but change the brain function through their epigenetic effect on stem cell fate and lineage
development. However, tools to systematically examine the epigenetic impact of environment on
neurodevelopment are lacking. Here we employ Microscopic Imaging of Epigenetic Landscape (MIEL) to
screen ToxCast Phase III chemical library (4700 compounds) and to characterize hits that alter epigenetic
landscape of human neural precursors without inducing cytotoxicity. Recognizing environmental insults and
understanding their mechanism of action will enable the development of regulations and guidelines aimed at
avoiding such insults and the development of antidotes and protective agents when exposure is unavoidable.
项目概要
神经发育障碍(NDD)越来越多地被认为是由神经发育失调引起的
早期大脑发育,代表着对环境化合物的脆弱性的一个窗口。
环境化合物可能通过表观遗传机制改变神经发育,这可能不会诱导
大量细胞死亡,但通过对干细胞命运和谱系的表观遗传效应改变大脑功能
发展。然而,系统地检查环境对表观遗传影响的工具
神经发育缺乏。在这里,我们采用表观遗传景观显微成像 (MIEL) 来
筛选 ToxCast 第三阶段化学库(4700 种化合物)并表征改变表观遗传的命中
人类神经前体的景观而不诱导细胞毒性。认识到环境侮辱和
了解其作用机制将有助于制定旨在
避免此类侮辱,并在暴露不可避免时开发解毒剂和保护剂。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ALEXEY V TERSKIKH其他文献
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{{ truncateString('ALEXEY V TERSKIKH', 18)}}的其他基金
Testing the utility of miBioAge as a personalized aging biomarker
测试 miBioAge 作为个性化衰老生物标志物的实用性
- 批准号:
10728233 - 财政年份:2023
- 资助金额:
$ 24.38万 - 项目类别:
Novel Strategy to Quantitate Delayed Aging by Caloric Restriction
通过热量限制来量化延迟衰老的新策略
- 批准号:
10594352 - 财政年份:2022
- 资助金额:
$ 24.38万 - 项目类别:
Novel Strategy to Quantitate Delayed Aging by Caloric Restriction
通过热量限制来量化延迟衰老的新策略
- 批准号:
10355362 - 财政年份:2022
- 资助金额:
$ 24.38万 - 项目类别:
Novel Strategy to Quantitate Delayed Aging by Caloric Restriction
通过热量限制来量化延迟衰老的新策略
- 批准号:
10570275 - 财政年份:2022
- 资助金额:
$ 24.38万 - 项目类别:
Role of Epigenetically Active Environmental Compounds in Neurodevelopmental Disorders
表观遗传活性环境化合物在神经发育障碍中的作用
- 批准号:
10219009 - 财政年份:2021
- 资助金额:
$ 24.38万 - 项目类别:
Role of Epigenetically Active Environmental Compounds in Neurodevelopmental Disorders
表观遗传活性环境化合物在神经发育障碍中的作用
- 批准号:
10395566 - 财政年份:2021
- 资助金额:
$ 24.38万 - 项目类别:
Phenotypic Screening for Longevity Interventions Using Single-cell Epigenetic Signatures
使用单细胞表观遗传特征进行长寿干预的表型筛选
- 批准号:
10225468 - 财政年份:2020
- 资助金额:
$ 24.38万 - 项目类别:
Role of Epigenetically Active Environmental Compounds in Neurodevelopmental Disorders
表观遗传活性环境化合物在神经发育障碍中的作用
- 批准号:
9979666 - 财政年份:2020
- 资助金额:
$ 24.38万 - 项目类别:
Phenotypic Screening for Longevity Interventions Using Single-cell Epigenetic Signatures
使用单细胞表观遗传特征进行长寿干预的表型筛选
- 批准号:
10043841 - 财政年份:2020
- 资助金额:
$ 24.38万 - 项目类别: