Role of Epigenetically Active Environmental Compounds in Neurodevelopmental Disorders

表观遗传活性环境化合物在神经发育障碍中的作用

基本信息

项目摘要

PROJECT SUMMARY Neurodevelopmental disorders (NDDs), are increasingly recognized as originating from dysregulation of early brain development, which represents a window of vulnerability to environmental compounds. Environmental compounds may alter neurodevelopment via epigenetic mechanisms, which may not induce massive cell death, but change the brain function through their epigenetic effect on stem cell fate and lineage development. However, tools to systematically examine the epigenetic impact of environment on neurodevelopment are lacking. Here we employ Microscopic Imaging of Epigenetic Landscape (MIEL) to screen ToxCast Phase III chemical library (4700 compounds) and to characterize hits that alter epigenetic landscape of human neural precursors without inducing cytotoxicity. Recognizing environmental insults and understanding their mechanism of action will enable the development of regulations and guidelines aimed at avoiding such insults and the development of antidotes and protective agents when exposure is unavoidable.
项目总结

项目成果

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ALEXEY V TERSKIKH其他文献

ALEXEY V TERSKIKH的其他文献

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{{ truncateString('ALEXEY V TERSKIKH', 18)}}的其他基金

Testing the utility of miBioAge as a personalized aging biomarker
测试 miBioAge 作为个性化衰老生物标志物的实用性
  • 批准号:
    10728233
  • 财政年份:
    2023
  • 资助金额:
    $ 24.38万
  • 项目类别:
Novel Strategy to Quantitate Delayed Aging by Caloric Restriction
通过热量限制来量化延迟衰老的新策略
  • 批准号:
    10594352
  • 财政年份:
    2022
  • 资助金额:
    $ 24.38万
  • 项目类别:
Novel Strategy to Quantitate Delayed Aging by Caloric Restriction
通过热量限制来量化延迟衰老的新策略
  • 批准号:
    10355362
  • 财政年份:
    2022
  • 资助金额:
    $ 24.38万
  • 项目类别:
Novel Strategy to Quantitate Delayed Aging by Caloric Restriction
通过热量限制来量化延迟衰老的新策略
  • 批准号:
    10570275
  • 财政年份:
    2022
  • 资助金额:
    $ 24.38万
  • 项目类别:
Role of Epigenetically Active Environmental Compounds in Neurodevelopmental Disorders
表观遗传活性环境化合物在神经发育障碍中的作用
  • 批准号:
    10219009
  • 财政年份:
    2021
  • 资助金额:
    $ 24.38万
  • 项目类别:
Role of Epigenetically Active Environmental Compounds in Neurodevelopmental Disorders
表观遗传活性环境化合物在神经发育障碍中的作用
  • 批准号:
    10395566
  • 财政年份:
    2021
  • 资助金额:
    $ 24.38万
  • 项目类别:
Phenotypic Screening for Longevity Interventions Using Single-cell Epigenetic Signatures
使用单细胞表观遗传特征进行长寿干预的表型筛选
  • 批准号:
    10225468
  • 财政年份:
    2020
  • 资助金额:
    $ 24.38万
  • 项目类别:
Role of Epigenetically Active Environmental Compounds in Neurodevelopmental Disorders
表观遗传活性环境化合物在神经发育障碍中的作用
  • 批准号:
    9979666
  • 财政年份:
    2020
  • 资助金额:
    $ 24.38万
  • 项目类别:
Phenotypic Screening for Longevity Interventions Using Single-cell Epigenetic Signatures
使用单细胞表观遗传特征进行长寿干预的表型筛选
  • 批准号:
    10043841
  • 财政年份:
    2020
  • 资助金额:
    $ 24.38万
  • 项目类别:
Role of MELK in glioblastomas
MELK 在胶质母细胞瘤中的作用
  • 批准号:
    7794961
  • 财政年份:
    2010
  • 资助金额:
    $ 24.38万
  • 项目类别:
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