Novel Strategy to Quantitate Delayed Aging by Caloric Restriction
通过热量限制来量化延迟衰老的新策略
基本信息
- 批准号:10594352
- 负责人:
- 金额:$ 41.09万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-02-15 至 2024-01-31
- 项目状态:已结题
- 来源:
- 关键词:ATAC-seqAgeAgingAlgorithmsAnimalsAttentionBayesian MethodBedsBiologicalCaloric RestrictionChromatinClassificationCommunitiesComputational algorithmDataData AnalysesData ScientistData SetDimensionsEcosystemEnsureFeedbackGene ExpressionGeometryImageIndividualLabelMachine LearningMapsMeasurementMemoryMethodsModalityModelingMultiomic DataMusPeer ReviewPhenotypePlant LeavesProgramming LanguagesPublicationsPythonsQuality ControlReadinessResearchResearch PersonnelRunningStructureTestingTextureTranscriptVariantVisualizationWorkXCL1 geneanalysis pipelineautoencoderbasecellular imagingcloud platformcomputational pipelinesdata modelingdata streamsdata structuredeep learning modeldesigndietary controldietary restrictiondigital repositoriesexperimental studyfile formatgenome sequencingimprovedmetabolomicsmicroscopic imagingmultidimensional datamultimodal datamultimodalityneural networknovel strategiestooltranscriptome sequencingwhole genome
项目摘要
PROJECT SUMMARY
The parental application proposed to integrate single cell imaging, ATAC-seq, and RNA-seq data from control
diet mice and caloric restriction (CR) diet mice. These experiments will provide a large amount of
multidimensional and multimodal data that not just suited for AI/ML applications, but in fact, require AI/ML
approaches to make sense of the vast datasets. However, these datasets are coming from 3 different type of
measurements (microscopic imaging, chromatin accessibility, and gene expression) of which 2 modalities
(imaging and sequencing) are very different. At present all three data streams are handled in conventional ways
primarily using very large Excel files; this data structure / format is not suitable for AI/ML integration. Hence the
need for individual approaches to cleaning, filtering, and quality control (QC) of imaging data, ATAC-seq and
RNA-seq data. Next critical step is to structure these diverse datasets in a similar format that streamlines storage
and handling and enabling downstream integration and analyses using AI/ML algorithms. To meet these
challenges, we will implement the AnnData format, which offers a broad range of computationally efficient
features including, among others, sparse data support, Scanpy, and a PyTorch interface. To ensure that
AnnData from very different modalities (imaging, ATAC-seq, RNA-seq) could be analyzed together, we will test
run already developed computational algorithms that best suited to efficiently assimilate and combine multi-
omics data to identify key factors that drive aging. We will combine AnnData objects from imaging, ATAC-seq,
and RNA-seq using Bayesian methods for integrating multi-omics data and hyperbolic embedding with principled
criteria for choosing the best-fitting curvature and dimension. To further test the utility of the embedded data we
will test run CNN with VAEs and GAN on the ensemble of embedded data to ensure the endpoint readiness and
to obtain initial feedback from different AI/ML applications. Finally, we will establish an electronic repository for
python scripts and AnnData objects and structures for a straightforward dissemination to the broad research
community.
项目总结
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
ALEXEY V TERSKIKH其他文献
ALEXEY V TERSKIKH的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('ALEXEY V TERSKIKH', 18)}}的其他基金
Testing the utility of miBioAge as a personalized aging biomarker
测试 miBioAge 作为个性化衰老生物标志物的实用性
- 批准号:
10728233 - 财政年份:2023
- 资助金额:
$ 41.09万 - 项目类别:
Novel Strategy to Quantitate Delayed Aging by Caloric Restriction
通过热量限制来量化延迟衰老的新策略
- 批准号:
10355362 - 财政年份:2022
- 资助金额:
$ 41.09万 - 项目类别:
Novel Strategy to Quantitate Delayed Aging by Caloric Restriction
通过热量限制来量化延迟衰老的新策略
- 批准号:
10570275 - 财政年份:2022
- 资助金额:
$ 41.09万 - 项目类别:
Role of Epigenetically Active Environmental Compounds in Neurodevelopmental Disorders
表观遗传活性环境化合物在神经发育障碍中的作用
- 批准号:
10219009 - 财政年份:2021
- 资助金额:
$ 41.09万 - 项目类别:
Role of Epigenetically Active Environmental Compounds in Neurodevelopmental Disorders
表观遗传活性环境化合物在神经发育障碍中的作用
- 批准号:
10395566 - 财政年份:2021
- 资助金额:
$ 41.09万 - 项目类别:
Phenotypic Screening for Longevity Interventions Using Single-cell Epigenetic Signatures
使用单细胞表观遗传特征进行长寿干预的表型筛选
- 批准号:
10225468 - 财政年份:2020
- 资助金额:
$ 41.09万 - 项目类别:
Role of Epigenetically Active Environmental Compounds in Neurodevelopmental Disorders
表观遗传活性环境化合物在神经发育障碍中的作用
- 批准号:
10271253 - 财政年份:2020
- 资助金额:
$ 41.09万 - 项目类别:
Role of Epigenetically Active Environmental Compounds in Neurodevelopmental Disorders
表观遗传活性环境化合物在神经发育障碍中的作用
- 批准号:
9979666 - 财政年份:2020
- 资助金额:
$ 41.09万 - 项目类别:
Phenotypic Screening for Longevity Interventions Using Single-cell Epigenetic Signatures
使用单细胞表观遗传特征进行长寿干预的表型筛选
- 批准号:
10043841 - 财政年份:2020
- 资助金额:
$ 41.09万 - 项目类别:
相似国自然基金
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
- 批准号:JCZRQN202500010
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
- 批准号:2025JJ70209
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
- 批准号:
- 批准年份:2024
- 资助金额:0 万元
- 项目类别:面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
- 批准号:2023JJ50274
- 批准年份:2023
- 资助金额:0.0 万元
- 项目类别:省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
- 批准号:
- 批准年份:2022
- 资助金额:33 万元
- 项目类别:地区科学基金项目
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
- 批准号:n/a
- 批准年份:2022
- 资助金额:10.0 万元
- 项目类别:省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
- 批准号:81973577
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
- 批准号:81602908
- 批准年份:2016
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
- 批准号:81501928
- 批准年份:2015
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
相似海外基金
The Phenomenon of Stem Cell Aging according to Methylation Estimates of Age After Hematopoietic Stem Cell Transplantation
根据造血干细胞移植后甲基化年龄估算干细胞衰老现象
- 批准号:
23K07844 - 财政年份:2023
- 资助金额:
$ 41.09万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Analysis of Age-dependent Functional Changes in Skeletal Muscle CB1 Receptors by an in Vitro Model of Aging-related Muscle Atrophy
通过衰老相关性肌肉萎缩的体外模型分析骨骼肌 CB1 受体的年龄依赖性功能变化
- 批准号:
22KJ2960 - 财政年份:2023
- 资助金额:
$ 41.09万 - 项目类别:
Grant-in-Aid for JSPS Fellows
Joint U.S.-Japan Measures for Aging and Dementia Derived from the Prevention of Age-Related and Noise-induced Hearing Loss
美日针对预防与年龄相关和噪声引起的听力损失而导致的老龄化和痴呆症联合措施
- 批准号:
23KK0156 - 财政年份:2023
- 资助金额:
$ 41.09万 - 项目类别:
Fund for the Promotion of Joint International Research (International Collaborative Research)
The Effects of Muscle Fatigability on Gait Instability in Aging and Age-Related Falls Risk
肌肉疲劳对衰老步态不稳定性和年龄相关跌倒风险的影响
- 批准号:
10677409 - 财政年份:2023
- 资助金额:
$ 41.09万 - 项目类别:
Characterizing gut physiology by age, frailty, and sex: assessing the role of the aging gut in "inflamm-aging"
按年龄、虚弱和性别表征肠道生理学特征:评估衰老肠道在“炎症衰老”中的作用
- 批准号:
497927 - 财政年份:2023
- 资助金额:
$ 41.09万 - 项目类别:
Deciphering the role of osteopontin in the aging eye and age-related macular degeneration
破译骨桥蛋白在眼睛老化和年龄相关性黄斑变性中的作用
- 批准号:
10679287 - 财政年份:2023
- 资助金额:
$ 41.09万 - 项目类别:
Role of AGE/RAGEsignaling as a driver of pathological aging in the brain
AGE/RAGE信号传导作为大脑病理性衰老驱动因素的作用
- 批准号:
10836835 - 财政年份:2023
- 资助金额:
$ 41.09万 - 项目类别:
Elucidation of the protein kinase NLK-mediated aging mechanisms and treatment of age-related diseases
阐明蛋白激酶NLK介导的衰老机制及年龄相关疾病的治疗
- 批准号:
23K06378 - 财政年份:2023
- 资助金额:
$ 41.09万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Underlying mechanisms of age-related changes in ingestive behaviors: From the perspective of the aging brain and deterioration of the gustatory system.
与年龄相关的摄入行为变化的潜在机制:从大脑老化和味觉系统退化的角度来看。
- 批准号:
23K10845 - 财政年份:2023
- 资助金额:
$ 41.09万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Targeting Age-Activated Proinflammatory Chemokine Signaling by CCL2/11 to Enhance Skeletal Muscle Regeneration in Aging
通过 CCL2/11 靶向年龄激活的促炎趋化因子信号传导以增强衰老过程中的骨骼肌再生
- 批准号:
478877 - 财政年份:2023
- 资助金额:
$ 41.09万 - 项目类别:
Operating Grants