The Mass-SIREN Group

Mass-SIRN 集团

• 批准号: 10620460
• 负责人: Joshua N Goldstein
• 金额: $ 10.87万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10620460
• 关键词: Administrative Supplement; Boston; Childhood; Clinical Research; Clinical Trials Network; Emergency Care; Enrollment; Funding; General Hospitals; Hospitals; Institution; Israel; Ketamine; Massachusetts; Medical center; Medical emergency; Modeling; Network-based; New England; Office of Administrative Management; Patient Care; Patients; Pediatric Hospitals; Principal Investigator; Research Personnel; Site; Status Epilepticus; Universities; Vermont; Woman; Work; clinical center; clinical trial enrollment; improved; innovation; meetings; novel; programs; tertiary care

Project Summary/Abstract: This application will continue support for a New England based Network Clinical Center (Hub) for the Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN). We propose to continue our integrated, collaborative team of high-volume tertiary care medical centers with expertise in emergency care clinical research. Our core institutions include Beth Israel Deaconess Medical Center (BIDMC), Boston Children's Hospital (BCH), Boston Medical Center (BMC), Brigham & Women's Hospital (BWH), Dartmouth Hitchcock Medical Center (DHMC), Massachusetts General Hospital (MGH), UMass Memorial Medical Center (UMMMC), and University of Vermont Medical Center (UVM). The team will continue to function administratively as a Hub and Spoke model, but operationally as a collaborative team of medical centers. Specific Aims include: Aim 1: To continue to manage an administrative Hub for the SIREN Clinical Trials Network at Massachusetts General Hospital (MGH). We will continue to coordinate activities with the CCC, our Hub, and Spokes, including attendance at SIREN investigator meetings. Aim 2. To continue to support enrollment in ICECAP at MGH, Yale-New Haven Hospital, and Beth Israel Deaconess Medical Center. We will work to launch Brigham & Women's Hospital as an ICECAP site over the next 6 months. We will work to support enrollment in the Pediatric ICECAP trial and are working with both MGH and Yale-New Haven Hospital to prepare for participation and study launch. Aim 3. To continue to support enrollment in BOOST-3 at MGH, Yale-New Haven Hospital, UMass Medical Center, and Beth Israel Deaconess Medical Center. We will work to launch Brigham & Women's Hospital as a BOOST-3 site over the next 6 months. We will also support enrollment in the BOOST-3 ancillary trials Bio- BOOST and Electro-BOOST. Aim 4: To continue to support submission of novel trials. In coordination with the SIREN CCC, two of our Mass-SIREN investigators are working to submit the KESETT (Ketamine for Status Epilepticus) trial for funding.

项目摘要/摘要： 此应用程序将继续支持总部位于新英格兰的网络临床中心(HUB) 创新紧急护理临床试验网络(SIREN)的策略。我们建议继续我们的 具有急救专业知识的大容量三级护理医疗中心的集成、协作团队 临床研究。我们的核心机构包括波士顿贝丝以色列女执事医疗中心(BIDMC) 儿童医院(BCH)、波士顿医学中心(BMC)、布里格姆妇女医院(BWH)、达特茅斯 希区柯克医疗中心(DHMC)、马萨诸塞州总医院(MGH)、马萨诸塞州纪念医疗中心 (UMMMC)和佛蒙特州大学医学中心(UVM)。该团队将继续发挥作用 在管理上作为中心和辐射型模式，但在操作上作为医疗中心的协作团队。 具体目标包括： 目标1：继续管理SIREN临床试验网络的管理中心，地址为 麻省总医院(MGH)。我们将继续与CCC、我们的枢纽和 发言，包括出席警报员会议。 目标2.继续支持MGH、耶鲁-纽黑文医院和贝丝以色列分校参加ICECAP 女执事医疗中心。我们将致力于将布里格姆妇女医院作为ICECAP网站在 接下来的6个月。我们将努力支持儿科ICECAP试验的登记，并正在与这两个项目合作 麻省理工学院和耶鲁-纽黑文医院准备参与并启动研究。 目标3.继续支持加州大学马萨诸塞州耶鲁大学纽黑文医院MGH Boost-3的注册 中心和贝丝以色列女执事医疗中心。我们将致力于将布里格姆妇女医院作为 Boost-3网站在接下来的6个月里。我们还将支持Boost-3辅助试验Bio-3的注册 助推器和电子助力器。 目标4：继续支持提交新的试验。在警报局的协调下，我们的两个 大规模警示调查人员正在努力将KESETT(用于癫痫持续状态的氯胺酮)试验提交给 资金问题。