The Mass-SIREN Group

Mass-SIRN 集团

• 批准号: 10197232
• 负责人: Joshua N Goldstein
• 金额: $ 16.76万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10197232
• 关键词: Accident and Emergency department; Acute; Administrative Coordination; Area; Boston; Cardiology; Cardiopulmonary; Child; Clinical; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; Community Hospitals; Data; Disease; Emergency Care; Emergency Department patient; Emergency Situation; Emergency research; Enrollment; Ensure; Funding; General Hospitals; Hematology; Hospitals; Individual; Infrastructure; International; Israel; Joints; Leadership; Massachusetts; Medical; Medical center; Medical emergency; Modeling; Neurologic; Neurology; New England; Operative Surgical Procedures; Patient Care; Patient Recruitments; Patients; Pediatric Hospitals; Performance; Positioning Attribute; Pre-hospital setting; Pre-hospitalization care; Protocol Compliance; Protocols documentation; Provider; Public Health; Publications; Pulmonology; Recording of previous events; Research; Research Infrastructure; Research Personnel; Resources; Rural; Specialist; Training; Trauma; Trauma Research; Universities; Woman; acute care; clinical center; design; experience; flexibility; improved; innovation; medical specialties; member; novel; pragmatic trial; provider networks; rural setting; suburb; tertiary care; underserved minority

This application will create a Network Clinical Center (Hub) for the Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN). We propose an integrated, collaborative team of high volume tertiary care medical centers with expertise in emergency care clinical research. The team includes an administrative Hub at Massachusetts General Hospital (MGH) with Spokes across the state including Baystate Medical Center, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Boston Medical Center, Brigham & Women's Hospital, UMass Memorial Medical Center, and St. Vincent Hospital. The Mass-SIREN Group will be managed by a Steering Committee including leaders from each of the member hospitals. It will function administratively as a Hub and Spoke model, but operationally as a collaborative team of medical centers. Our team also includes nationally- and internationally-recognized leaders in neurology, cardiology, pulmonology, hematology, and trauma; we will propose novel ideas for the SIREN network, and innovative solutions to common problems in clinical trials including enrollment and retention. Specific Aims include: Aim 1: To establish an administrative Hub for the SIREN Clinical Trials Network at MGH. This Hub will enroll in each clinical trial. Additionally it will provide administrative coordination across the entire team. Aim 2. To establish the Mass-SIREN Steering Committee, an integrated leadership team that will coordinate trial management and enrollment across all of our centers. Aim 3. To provide our existing network of prehospital providers with the regulatory and educational infrastructure to ensure that trained EMS teams can successfully participate in SIREN clinical trials. Aim 4. To further establish the Mass-SIREN Steering Committee as innovative leaders in emergency care research. We will leverage our individual areas of expertise, our local co-investigators, and our colleagues with subspecialty expertise to design and propose innovative trials for the entire SIREN network. Our academic centers have experience conducting clinical emergency care research, and all have existing pools of trained clinical research coordinators that actively screen in the Emergency Department (ED) to manage enrollment and protocol compliance. Our hospitals see a wide range of patients, including children, underserved minorities, as well as those in urban, suburban, and rural settings. We include all major prehospital providers in Boston and across Massachusetts. Finally, this application highlights our long history of demonstrated interdisciplinary relationships, and that our team has a proven record of joint collaboration, trial performance, and scientific publication. Overall, the MASS-Siren Group includes both the breadth and depth of experience and resources to be an outstanding Network Clinical Center for SIREN.

该应用程序将创建一个网络临床中心（HUB），以创新紧急策略 护理临床试验网络（Siren）。我们提出了一个大型第三级的综合合作团队 护理医疗中心具有急诊临床研究专业知识。团队包括一个行政 马萨诸塞州综合医院（MGH）的枢纽，全州辐条，包括Baystate Medical 中心，贝丝以色列女执事医疗中心，波士顿儿童医院，波士顿医疗中心，杨百翰＆ 妇女医院，UMASS纪念医疗中心和圣文森特医院。群众组将 由指导委员会管理，包括来自每个会员医院的领导人。它将起作用 在行政上是一个枢纽和讲话模型，但在运营上是医疗中心的协作团队。我们的 团队还包括国际和国际公认的神经病学，心脏病学，肺病学领导者， 血液学和创伤；我们将为警笛网络提出新颖的想法，以及创新的解决方案 临床试验中的常见问题，包括入学和保留。具体目的包括： 目标1：在MGH建立一个警笛临床试验网络的管理中心。这个枢纽会 参加每个临床试验。此外，它将在整个团队中提供行政协调。 目标2。建立大规模塞伦指导委员会，这是一个综合领导团队，将 协调我们所有中心的试用管理和注册。 目标3。为我们现有的院前提供商网络提供监管和教育 确保受过训练的EMS团队的基础设施可以成功参加Siren临床试验。 目的4。进一步建立大规模塞伦指导委员会作为紧急情况的创新领导者 护理研究。我们将利用我们的各个专业领域，当地的共同研究人员和我们的同事 凭借专业知识，可以为整个警笛网络设计和提出创新试验。 我们的学术中心有进行临床紧急护理研究的经验，并且都有 现有的训练有素的临床研究协调员池，这些协调员在急诊科积极筛查（ED） 管理注册和协议合规。我们的医院看到包括儿童在内的各种患者 服务不足的少数民族以及城市，郊区和农村环境中的少数民族。我们包括所有专业 波士顿和马萨诸塞州的院前提供商。最后，该应用程序突出了我们悠久的历史 有展示的跨学科关系，我们的团队具有共同合作的可靠记录， 试验性能和科学出版物。 总体而言，大众群体包括经验和资源的广度和深度 警笛的杰出网络临床中心。