The Mass-SIREN Group

该应用程序将创建一个网络临床中心(HUB)，用于创新应急策略 关怀临床试验网络(SIREN)。我们提出了一个整合的、协作的高容量第三方团队 具有急救护理临床研究专业知识的护理医疗中心。该团队包括一名行政人员 位于马萨诸塞州综合医院(MGH)的中心，在全州范围内拥有Spokes，包括BayState Medical 波士顿儿童医院贝丝以色列女执事医疗中心，波士顿医疗中心，Brigham& 妇女医院、马萨诸塞州纪念医疗中心和圣文森特医院。群众警报团将成为 由一个指导委员会管理，该委员会包括每个成员医院的领导人。它会起作用的 在管理上作为中心和辐射型模式，但在操作上作为医疗中心的协作团队。我们的 团队还包括国内和国际公认的神经学、心脏病学、肺病学、 血液学和创伤；我们将为警报网提出新的想法，并提出创新的解决方案 临床试验中常见的问题包括登记和保留。具体目标包括： 目标1：在麻省总医院建立SIREN临床试验网络的管理中心。该中心将 登记参加每项临床试验。此外，它还将在整个团队中提供行政协调。 目标2.建立群众警报器指导委员会，这是一个综合领导小组，将 协调我们所有中心的试验管理和登记。 目标3.为我们现有的院前提供者网络提供监管和教育 基础设施，以确保训练有素的EMS团队能够成功地参与SIREN临床试验。 目标4.进一步建立群众警报器指导委员会，作为紧急情况下的创新领导者 关爱研究。我们将利用我们各自的专业领域、我们的当地合作调查员和我们的同事 拥有专门的专业知识，为整个警报网设计和提出创新的试验。 我们的学术中心都有进行临床急救研究的经验，并且都有 现有的训练有素的临床研究协调员在急诊科(ED)积极筛选 管理注册和协议合规性。我们医院接诊的病人范围很广，包括儿童， 服务不足的少数群体，以及城市、郊区和农村环境中的少数群体。我们包括了所有主要的 波士顿和马萨诸塞州的医院前提供者。最后，这款应用程序突出了我们悠久的历史 证明了跨学科的关系，我们的团队有经过验证的联合合作记录， 试演，科学出版。 总体而言，大众警报组包括广度和深度的经验和资源 卓越的网络警报器临床中心。

This application will create a Network Clinical Center (Hub) for the Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN). We propose an integrated, collaborative team of high volume tertiary care medical centers with expertise in emergency care clinical research. The team includes an administrative Hub at Massachusetts General Hospital (MGH) with Spokes across the state including Baystate Medical Center, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Boston Medical Center, Brigham & Women's Hospital, UMass Memorial Medical Center, and St. Vincent Hospital. The Mass-SIREN Group will be managed by a Steering Committee including leaders from each of the member hospitals. It will function administratively as a Hub and Spoke model, but operationally as a collaborative team of medical centers. Our team also includes nationally- and internationally-recognized leaders in neurology, cardiology, pulmonology, hematology, and trauma; we will propose novel ideas for the SIREN network, and innovative solutions to common problems in clinical trials including enrollment and retention. Specific Aims include: Aim 1: To establish an administrative Hub for the SIREN Clinical Trials Network at MGH. This Hub will enroll in each clinical trial. Additionally it will provide administrative coordination across the entire team. Aim 2. To establish the Mass-SIREN Steering Committee, an integrated leadership team that will coordinate trial management and enrollment across all of our centers. Aim 3. To provide our existing network of prehospital providers with the regulatory and educational infrastructure to ensure that trained EMS teams can successfully participate in SIREN clinical trials. Aim 4. To further establish the Mass-SIREN Steering Committee as innovative leaders in emergency care research. We will leverage our individual areas of expertise, our local co-investigators, and our colleagues with subspecialty expertise to design and propose innovative trials for the entire SIREN network. Our academic centers have experience conducting clinical emergency care research, and all have existing pools of trained clinical research coordinators that actively screen in the Emergency Department (ED) to manage enrollment and protocol compliance. Our hospitals see a wide range of patients, including children, underserved minorities, as well as those in urban, suburban, and rural settings. We include all major prehospital providers in Boston and across Massachusetts. Finally, this application highlights our long history of demonstrated interdisciplinary relationships, and that our team has a proven record of joint collaboration, trial performance, and scientific publication. Overall, the MASS-Siren Group includes both the breadth and depth of experience and resources to be an outstanding Network Clinical Center for SIREN.