The Mass-SIREN Group

Mass-SIRN 集团

• 批准号: 10197232
• 负责人: Joshua N Goldstein
• 金额: $ 16.76万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10197232
• 关键词: Accident and Emergency department; Acute; Administrative Coordination; Area; Boston; Cardiology; Cardiopulmonary; Child; Clinical; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; Community Hospitals; Data; Disease; Emergency Care; Emergency Department patient; Emergency Situation; Emergency research; Enrollment; Ensure; Funding; General Hospitals; Hematology; Hospitals; Individual; Infrastructure; International; Israel; Joints; Leadership; Massachusetts; Medical; Medical center; Medical emergency; Modeling; Neurologic; Neurology; New England; Operative Surgical Procedures; Patient Care; Patient Recruitments; Patients; Pediatric Hospitals; Performance; Positioning Attribute; Pre-hospital setting; Pre-hospitalization care; Protocol Compliance; Protocols documentation; Provider; Public Health; Publications; Pulmonology; Recording of previous events; Research; Research Infrastructure; Research Personnel; Resources; Rural; Specialist; Training; Trauma; Trauma Research; Universities; Woman; acute care; clinical center; design; experience; flexibility; improved; innovation; medical specialties; member; novel; pragmatic trial; provider networks; rural setting; suburb; tertiary care; underserved minority

This application will create a Network Clinical Center (Hub) for the Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN). We propose an integrated, collaborative team of high volume tertiary care medical centers with expertise in emergency care clinical research. The team includes an administrative Hub at Massachusetts General Hospital (MGH) with Spokes across the state including Baystate Medical Center, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Boston Medical Center, Brigham & Women's Hospital, UMass Memorial Medical Center, and St. Vincent Hospital. The Mass-SIREN Group will be managed by a Steering Committee including leaders from each of the member hospitals. It will function administratively as a Hub and Spoke model, but operationally as a collaborative team of medical centers. Our team also includes nationally- and internationally-recognized leaders in neurology, cardiology, pulmonology, hematology, and trauma; we will propose novel ideas for the SIREN network, and innovative solutions to common problems in clinical trials including enrollment and retention. Specific Aims include: Aim 1: To establish an administrative Hub for the SIREN Clinical Trials Network at MGH. This Hub will enroll in each clinical trial. Additionally it will provide administrative coordination across the entire team. Aim 2. To establish the Mass-SIREN Steering Committee, an integrated leadership team that will coordinate trial management and enrollment across all of our centers. Aim 3. To provide our existing network of prehospital providers with the regulatory and educational infrastructure to ensure that trained EMS teams can successfully participate in SIREN clinical trials. Aim 4. To further establish the Mass-SIREN Steering Committee as innovative leaders in emergency care research. We will leverage our individual areas of expertise, our local co-investigators, and our colleagues with subspecialty expertise to design and propose innovative trials for the entire SIREN network. Our academic centers have experience conducting clinical emergency care research, and all have existing pools of trained clinical research coordinators that actively screen in the Emergency Department (ED) to manage enrollment and protocol compliance. Our hospitals see a wide range of patients, including children, underserved minorities, as well as those in urban, suburban, and rural settings. We include all major prehospital providers in Boston and across Massachusetts. Finally, this application highlights our long history of demonstrated interdisciplinary relationships, and that our team has a proven record of joint collaboration, trial performance, and scientific publication. Overall, the MASS-Siren Group includes both the breadth and depth of experience and resources to be an outstanding Network Clinical Center for SIREN.

此应用程序将为EmeRgENcy创新策略创建网络临床中心（中心） 护理临床试验网络（SIREN）。我们建议建立一个综合的、协作的高容量三级团队， 护理医疗中心在紧急护理临床研究的专业知识。该团队包括一名行政 位于马萨诸塞州总医院（MGH）的中心，在全州设有分支机构，包括Baystate Medical 中心，贝丝以色列女执事医疗中心，波士顿儿童医院，波士顿医疗中心，布里格姆和 妇女医院，马萨诸塞大学纪念医疗中心和圣文森特医院。Mass-SIREN集团将在 由一个指导委员会管理，该委员会包括各成员医院的领导。它将功能 在行政上作为一个中心和辐射模型，但在操作上作为一个医疗中心的协作团队。我们 团队还包括国内和国际公认的神经病学，心脏病学，肺病学， 血液学和创伤;我们将为SIREN网络提出新的想法，并为 临床试验中的常见问题，包括入组和保留。具体目标包括： 目标1：在MGH建立SIREN临床试验网络的管理中心。该中心将 参加每项临床试验。此外，它还将为整个团队提供行政协调。 目标2.建立一个综合领导小组-大众警报系统指导委员会， 协调我们所有中心的试验管理和入组。 目标3.为我们现有的院前服务提供者网络提供监管和教育， 基础设施，以确保训练有素的EMS团队能够成功参与SIREN临床试验。 目标4。进一步建立大众警报指导委员会，作为紧急情况下的创新领导者 护理研究。我们将利用我们的专业领域，我们的当地合作研究者和我们的同事 拥有专业知识，为整个SIREN网络设计和提出创新试验。 我们的学术中心都有进行临床急救护理研究的经验， 在急诊科（艾德）积极筛查的现有训练有素的临床研究协调员库 管理入组和方案依从性。我们医院的病人范围很广，包括儿童， 服务不足的少数民族，以及那些在城市，郊区和农村环境。包括所有主要 波士顿和整个马萨诸塞州的院前服务提供者。最后，这一应用凸显了我们悠久的历史 证明跨学科的关系，我们的团队有一个共同合作的证明记录， 试验性能和科学出版物。 总的来说，大众警报器集团包括广度和深度的经验和资源， 一个杰出的SIREN网络临床中心。