The Boston NETT Group

描述(由申请人提供)：我们建议创建波士顿NETT网站，这是一个由波士顿的医院和EMS机构组成的团队，将作为NETT网络的顶级注册网站和充满活力的贡献者。我们的团队包括波士顿所有的成人I级创伤中心。所有医院在临床试验的成功管理和表现方面都有经过证明的记录。特别是，所有医院都建立了研究基础设施，在急诊科和神经科进行持续的临床研究，可以利用这些基础设施来满足NETT的需求。首席研究员乔舒亚·N·戈尔茨坦，医学博士，博士和合作研究员乔纳森·罗桑德，医学博士，医学硕士，在管理成功的临床研究计划、指导委员会成员和各自领域的国家领导职位方面带来了一套互补的技能。我们的团队包括神经学和急诊医学方面的研究人员，他们拥有国家公认的专业知识，管理着将患者纳入急救环境的艰巨任务。波士顿NETT集团的优势包括1)多名研究人员之间密切的个人和专业联系，如成功合作研究项目的历史所表明的那样；2)来自大城市地区的大量人口，横跨各种神经疾病；3)具有科学成就和创新记录的现场调查人员才华横溢的团队，以及多中心试验中的受试者招募和数据管理；4)现有的研究基础设施，由包括NINDS在内的一系列来源资助，可用于满足NETT的需求；5)众多现有的临床研究项目，包括神经病学临床试验单位、哈佛大学临床与转化科学奖(CTSA)项目、波士顿大学临床与转化科学(CTSA)研究所、急性卒中转化研究(SPOTRIAS)网络、NeuroNEXT网络和NeuroNEXT临床协调中心等专门项目；6)与波士顿EMS和Boston Medflix等院前服务紧密结合。总体而言，波士顿NETT集团拥有资源、远见和热情来加强NETT网络的持续成功。

DESCRIPTION (provided by applicant): We propose to create the Boston NETT Site, a team of hospitals and EMS agencies in Boston that will serve as a top-enrolling site and vibrant contributor to the NETT Network. Our group includes all adult Level I trauma centers in the city of Boston. All hospitals have a proven track record of successful management and performance of clinical trials. In particular, all hospitals have an established research infrastructure that performs ongoing clinical research in both emergency and neurology departments, which can be leveraged to meet the needs of NETT. Principal investigator Joshua N. Goldstein, MD, PhD, and Co-investigator Jonathan Rosand, MD, MS bring a complementary set of skills in managing successful clinical research programs, membership on Steering Committees, and positions of national leadership in their fields. Our team includes investigators in neurology and emergency medicine with nationally recognized expertise managing the difficult task of enrolling patients in the emergency setting. Strengths of the Boston NETT Group include 1) the close personal and professional ties between multiple investigators, as shown by a history of successful collaborative research projects; 2) a large population from a major metropolitan area that spans the full range of neurologic disorders; 3) talented teams of site Investigators with track records of scientific achievement and innovation, as well as subject recruitment and data management in multicenter trials; 4) an existing research infrastructure, funded by a range of sources including NINDS, which can be leveraged to meet the needs of NETT; 5) numerous existing clinical research programs including the Neurology Clinical Trials Unit, The Harvard Catalyst Clinical and Translational Science Award (CTSA) program, the BU Clinical and Translational Science (CTSA) Institute, the Specialized Programs of Translational Research in Acute Stroke (SPOTRIAS) Network, the NeuroNEXT Network, and the NeuroNEXT Clinical Coordinating Center; 6) close integration with pre-hospital services, including Boston EMS and Boston Medflight. Overall, the Boston NETT Group has the resources, vision, and enthusiasm to enhance the ongoing success of the NETT Network.