Demographic Distribution of Hand Joint Space

手关节空间的人口统计分布

基本信息

  • 批准号:
    10625656
  • 负责人:
  • 金额:
    $ 21.78万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-27 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

Project Summary/Abstract Osteoarthritis (OA) is the most common form of arthritis and is prevalent in many joints, including the joints of the hand. In order to increase the understanding of hand OA, it is necessary to understand the natural structure of these joints. Radiography is commonly used in the scientific and clinical evaluation which can include joint space width (JSW) measurement, which can progressively decline due to cartilage deterioration. When considering demographics, these JSW measures have the potential to be different, given the diversity of living conditions. With respect to the hand, radiographic JSW is more easily discernable in the finger joints, as opposed to the thumb; specifically, the thumb carpometacarpal joint (CMC), where the complex morphology can render 2D visualization challenging. However, with computed tomography (CT), the joint can be viewed in 3D and the JSW more readily assessed. With these factors to consider, the specific aims of this project are: (1) Establish age-specific distribution percentiles for JSW in the finger joints of African Americans and Whites, separately for men and women, for two time points, using data from the Osteoarthritis Initiative (OAI); and (2) Establish reference values and demographic distributions for the thumb CMC JSW using CT and evaluate the relationship with 2D radiographic JSW measurement. Aim 1 will utilize data from the OAI for approximately 3500 hand radiographs. These radiographs will be evaluated for JSW at two time points and separated by age, race and gender. For Aim 2, a cohort of 25 males and 25 females will be recruited. A radiograph and CT scan of each of the participant hands will be taken. 3D models will be constructed from the CT images, from which CMC JSW measurements will be made and similar demographic information will be drawn. The CT measurements will then be used to identify landmarks on the radiographic images to make the 2D JSW measurement. Statistical comparisons will be drawn between the two measurements and the results will be used in the formulation of novel relationships suitable for adjusting the 2D measurements for agreement with the 3D measurements. Ultimately, this work will result in the quantification of JSW for the entire hand. The longitudinal data for the finger joints will support the goals of the parent project in the future development of predictive models for OA development for at-risk populations. The framework developed for the thumb can be expanded for a larger population for the development of similar predictive models. This project supports the career development of the candidate by initiating research focused on the use of engineering processes and medical imaging, for the development of computational models which can be used to evaluate the mechanics of healthy and arthritic joints.
项目总结/文摘

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
An approach to understand osteoarthritis, comorbidity and excess mortality in the population.
一种了解人群中骨关节炎、合并症和超额死亡率的方法。
  • DOI:
    10.1093/rheumatology/kead172
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Nelson,AmandaE;Golightly,YvonneM
  • 通讯作者:
    Golightly,YvonneM
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JEFFREY W DURYEA其他文献

JEFFREY W DURYEA的其他文献

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{{ truncateString('JEFFREY W DURYEA', 18)}}的其他基金

Identifying determinants of rapid structural and/or clinical progression in knee osteoarthritis by quantitative assessment of structural features on radiographs
通过定量评估射线照片上的结构特征来确定膝骨关节炎快速结构和/或临床进展的决定因素
  • 批准号:
    10859277
  • 财政年份:
    2023
  • 资助金额:
    $ 21.78万
  • 项目类别:
Identifying determinants of rapid structural and/or clinical progression in knee osteoarthritis by quantitative assessment of structural features on radiographs
通过定量评估射线照片上的结构特征来确定膝骨关节炎快速结构和/或临床进展的决定因素
  • 批准号:
    10417354
  • 财政年份:
    2022
  • 资助金额:
    $ 21.78万
  • 项目类别:
Identifying determinants of rapid structural and/or clinical progression in knee osteoarthritis by quantitative assessment of structural features on radiographs
通过定量评估射线照片上的结构特征来确定膝骨关节炎快速结构和/或临床进展的决定因素
  • 批准号:
    10683361
  • 财政年份:
    2022
  • 资助金额:
    $ 21.78万
  • 项目类别:
Healthy knee aging vs. osteoarthritis in three large diverse cohorts: What is the clinical relevance of structural changes seen on radiographs?
三个不同队列中的健康膝关节老化与骨关节炎:X光片上看到的结构变化的临床相关性是什么?
  • 批准号:
    10096225
  • 财政年份:
    2021
  • 资助金额:
    $ 21.78万
  • 项目类别:
Tracking Treatable Tissues: Change in qMRI Biomarkers and Future Cartilage Loss
追踪可治疗组织:qMRI 生物标志物的变化和未来的软骨损失
  • 批准号:
    9762584
  • 财政年份:
    2017
  • 资助金额:
    $ 21.78万
  • 项目类别:
Quantitative MRI analysis method for longitudinal assessment of knee OA
膝关节骨关节炎纵向评估的定量MRI分析方法
  • 批准号:
    7784808
  • 财政年份:
    2010
  • 资助金额:
    $ 21.78万
  • 项目类别:
Quantitative MRI analysis method for longitudinal assessment of knee OA
膝关节骨关节炎纵向评估的定量MRI分析方法
  • 批准号:
    8215819
  • 财政年份:
    2010
  • 资助金额:
    $ 21.78万
  • 项目类别:
Quantitative MRI analysis method for longitudinal assessment of knee OA
膝关节骨关节炎纵向评估的定量MRI分析方法
  • 批准号:
    8013530
  • 财政年份:
    2010
  • 资助金额:
    $ 21.78万
  • 项目类别:
Bone-age assessment workstation software
骨龄评估工作站软件
  • 批准号:
    6805596
  • 财政年份:
    2003
  • 资助金额:
    $ 21.78万
  • 项目类别:
Bone-age assessment workstation software
骨龄评估工作站软件
  • 批准号:
    6703987
  • 财政年份:
    2003
  • 资助金额:
    $ 21.78万
  • 项目类别:

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