African Breast Cancer - Disparities in Outcomes - Plus (ABC-DO Plus): Ghana mentoring supplement

非洲乳腺癌 - 结果差异 - Plus (ABC-DO Plus)：加纳指导补充资料

• 批准号: 10622647
• 负责人: Isabel Dos Santos Silva
• 金额: $ 12.44万
• 依托单位: INTERNATIONAL AGENCY FOR RES ON CANCER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10622647
• 关键词: Africa; African; Agreement; Applications Grants; Attitude; Back; Biopsy; Breast Cancer Patient; Breast Cancer Treatment; Breast biopsy; Cancer Control; Cities; Collaborations; Complement; Country; Decision Making; Diagnosis; District Hospitals; Doctor of Philosophy; Epidemiologist; Ethics; Family; Funding; Funding Opportunities; Future; Ghana; Government; Grant; Health; Health Personnel; Health Services Accessibility; Health Status; Health system; Healthcare; Histologic; Hospitals; International; Interview; Investments; Knowledge; Lead; Leadership; Length; Link; Low income; Malignant - descriptor; Malignant Neoplasms; Mentors; Monitor; Nature; Newly Diagnosed; Oncologist; Oncology; Outcome; Parents; Patients; Pattern; Process; Prospective Studies; Public Health; Research; Research Design; Research Personnel; Research Project Grants; Rural; Science; Scientist; Time; Universities; Woman; Writing; anticancer research; barrier to care; base; breast cancer survival; cancer care; cancer health disparity; cancer type; career; career development; cohort; community based research; design; epidemiology study; experience; improved; low and middle-income countries; malignant breast neoplasm; palliative; prospective; recruit; skills; treatment center; willingness

Project Summary ABC-DO Ghana - Mentored Research on Breast Cancer in Ghana, West Africa The present funding opportunity relates to a supplement to support mentored career development of early-stage investigators from low- and middle-income countries in cancer research. In this application, which is linked to an existing R01-funded African Breast Cancer-Disparities in Outcomes (ABC-DO) study, we propose that Dr Clement Narh undertakes a study of attitudes and barriers to commencing breast cancer treatment among women diagnosed in rural and district-level settings in Ghana. Dr Narh is a young Ghanaian epidemiologist-statistician with experience in non-communicable diseases (NCD) and cancer. He is based at the University of Health and Allied Sciences in the Volta region of Ghana. His local study leadership, supported by an international team, would be an excellent investment for his personal career development and for Ghanaian and West African cancer research for decades to come. He is at a perfect career stage, having a strong academic background (PhD in NCDs) but not having yet led his own research project, thus he would gain skills in study management, independence, decision making, fieldwork organisation, research contractual agreements, networking and grant applications, which will complement his existing writing and analytical skills. Dr Narh, Ghanaian oncologists, public health scientists and NCD government planners, and the ABC- DO PIs have together developed the current proposal which will examine attitudes and barriers to commencing breast cancer treatment among women diagnosed in regional settings. The focus is on women not residing near major cities where oncology facilities are based, but in regional/district settings across the Volta region. Over 7 months, 100 women newly diagnosed with breast cancer in 6 district hospitals selected across the length of the Volta region, a low income non-capital regional setting, will be interviewed and followed to monitor treatment initiation. Findings will support strategies to reduce breast cancer disparities in district settings in West Africa, whilst Dr Narh will gain invaluable experience in independently leading this research, backed by mentored support. ABC-DO PIs will gain knowledge of a new country, Ghana, and experience of the cancer journey of women who may not reach tertiary hospitals where most current breast cancer treatment studies are based. A unique collaboration of invaluable local experience, know-how and an essential presence on the ground, with epidemiologic study design advice and mentoring guarantees a scientifically robust study and a successful productive collaboration.

项目摘要 ABC-DO Ghana -西非加纳乳腺癌辅导研究 目前的供资机会涉及一项补充，以支持以下人员的辅导职业发展： 来自低收入和中等收入国家的早期癌症研究人员。在本申请中， 这与现有的R 01资助的非洲乳腺癌-结果差异（ABC-DO）有关。 我们建议Clement Narh博士进行一项关于开始学习的态度和障碍的研究， 在加纳农村和地区一级诊断出患有乳腺癌的妇女中提供治疗。 Narh博士是一位年轻的加纳流行病学家-统计学家，在非传染性疾病方面有经验 (NCD)和癌症他是在健康和联合科学大学在沃尔特地区的， 加纳.他的本地研究领导，由一个国际团队的支持，将是一个优秀的 为他的个人职业发展以及加纳和西非癌症研究投资 未来几十年。他正处于一个完美的职业生涯阶段，拥有强大的学术背景（博士学位）。 非传染性疾病），但尚未领导自己的研究项目，因此他将获得学习管理技能， 独立性，决策，实地工作组织，研究合同协议，网络 和赠款申请，这将补充他现有的写作和分析技能。 Narh博士，加纳肿瘤学家，公共卫生科学家和NCD政府规划者，以及ABC- DO PI共同制定了当前的提案，该提案将审查对以下问题的态度和障碍： 在区域环境中开始对确诊的妇女进行乳腺癌治疗。重点是 居住地不在肿瘤学设施所在的大城市附近，但在区域/地区环境中的妇女 横跨沃尔特地区7个月内，6个区新诊断出100名妇女患有乳腺癌 在沃尔特地区（一个低收入的非首都地区）选择的医院将 接受访谈并随访，以监测治疗开始情况。调查结果将支持减少 西非地区乳腺癌的差异，而Narh博士将获得宝贵的经验， 在导师的支持下独立领导这项研究。ABC-DO PI将获得知识 一个新的国家，加纳，和经验的癌症旅程的妇女谁可能无法达到高等教育 目前大多数乳腺癌治疗研究的医院。独特的合作， 宝贵的当地经验、专门知识和在当地的重要存在， 研究设计建议和指导保证了科学的稳健研究和成功的生产 协作

项目成果

Reproductive history and breast cancer survival: Findings from the African breast cancer-Disparities in outcomes cohort and implications of Africa's fertility transition on breast cancer prognosis.

• DOI: 10.1002/ijc.34411
• 发表时间: 2023-05-01
• 期刊: International journal of cancer
• 影响因子: 6.4

Global and regional estimates of orphans attributed to maternal cancer mortality in 2020.

• DOI: 10.1038/s41591-022-02109-2
• 发表时间: 2022-12
• 期刊: NATURE MEDICINE
• 影响因子: 82.9
• 作者: Guida, Florence;Kidman, Rachel;Ferlay, Jacques;Schuz, Joachim;Soerjomataram, Isabelle;Kithaka, Benda;Ginsburg, Ophira;Vega, Raymond B. Mailhot;Galukande, Moses;Parham, Groesbeck;Vaccarella, Salvatore;Canfell, Karen;Ilbawi, Andre M.;Anderson, Benjamin O.;Bray, Freddie;dos-Santos-Silva, Isabel;McCormack, Valerie
• 通讯作者: McCormack, Valerie

Self-reported arm and shoulder problems in breast cancer survivors in Sub-Saharan Africa: the African Breast Cancer-Disparities in Outcomes cohort study.

• DOI: 10.1186/s13058-021-01486-9
• 发表时间: 2021-11-24
• 期刊: Breast cancer research : BCR
• 作者: Boucheron P;Anele A;Zietsman A;Galukande M;Parham G;Pinder LF;Andersson TM;Anderson BO;Foerster M;Schüz J;Dos Santos Silva I;McCormack V
• 通讯作者: McCormack V

Disparities in breast cancer survival between women with and without HIV across sub-Saharan Africa (ABC-DO): a prospective, cohort study.

撒哈拉以南非洲妇女和患有HIV的妇女之间的乳腺癌生存差异（ABC-DO）：一项前瞻性，同类研究。

• DOI: 10.1016/s2352-3018(21)00326-x
• 发表时间: 2022-03
• 期刊: LANCET HIV
• 影响因子: 16.1
• 作者: Chasimpha, Steady;McCormack, Valerie;Cubasch, Herbert;Joffe, Maureen;Zietsman, Annelle;Galukande, Moses;Parham, Groesbeck;Pinder, Leeya F.;Anele, Angelica;Adisa, Charles A.;Offiah, Awa Ukonye;Anderson, Benjamin O.;Boucheron, Pauline;Foerster, Milena;Schuz, Joachim;dos-Santos-Silva, Isabel
• 通讯作者: dos-Santos-Silva, Isabel

Maternally Orphaned Children and Intergenerational Concerns Associated With Breast Cancer Deaths Among Women in Sub-Saharan Africa.

• DOI: 10.1001/jamaoncol.2020.6583
• 发表时间: 2021-02-01
• 期刊: JAMA oncology
• 影响因子: 28.4
• 作者: Galukande M;Schüz J;Anderson BO;Zietsman A;Adisa C;Anele A;Parham G;Pinder LF;Mutumba S;Lombe D;Cabanes A;Foerster M;Dos-Santos-Silva I;McCormack V
• 通讯作者: McCormack V