Multilevel Comprehensive HIV Prevention for South African Adolescent Girls and Young Women

南非少女和年轻妇女的多层次综合艾滋病毒预防

• 批准号: 10620397
• 负责人: GERI R DONENBERG
• 金额: $ 8.46万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10620397
• 关键词: 19 year old; AIDS prevention; Address; Age; Attitude; Behavior; Caregivers; Communication; Data; Daughter; Development Plans; Doctor of Philosophy; Ensure; Family; Female; Female Adolescents; Foundations; Goals; HIV; HIV/STD; Incidence; Intervention; Knowledge; Mentors; Mentorship; Outcome; Parents; Physicians; Prevention; Prevention program; Randomized Controlled Trials; Reading; Research; Research Activity; Role; Scientist; Sexually Transmitted Diseases; South African; Specific qualifier value; Testing; Training; Training Activity; Underrepresented Minority; Women' s Health; adolescent health; arm; base; career; career development; experience; follow-up; global health; health disparity; high risk; implementation science; improved; medical schools; meetings; parent grant; parent project; primary outcome; research study; secondary outcome; skills; stem; transmission process; young woman

South African Adolescent Girls and Young Women (AGYW), ages 15 – 19 years-old, are at high risk of new sexually transmitted infections, including HIV. Ongoing efforts to stem transmissions have been disappointing. Family-based prevention programs are an underutilized approach in the HIV prevention toolkit, despite evidence of their promise in improving AGYW health prevention attitudes and behaviors. This one-year diversity supplement will support Alyssa Debra's career development as a physician scientist who is beginning her PhD after completing two years of medical school. Her research study builds on the parent grant, a 2-arm randomized controlled trial testing a female caregiver (FC)-daughter HIV/STI prevention program on South African AGYW STI and HIV incidence. Using UG3 pilot data from the parent study, Alyssa will evaluate two theoretical mechanisms believed to explain change in AGYW STI and HIV outcomes: FC-AGYW relationships and communication, and AGYW HIV/STI knowledge, attitudes, and skills. Alyssa will examine change in these mechanisms from baseline to 6-month follow-up (after the intervention), and she will compare changes in the experimental and control arms. Findings will set the stage to evaluate the role of these mechanisms on the primary and secondary outcomes of the parent project. The career development plan specifies a combination of hands-on experiential training, coursework, guided readings, one-on-one meetings with mentors, and networking opportunities to achieve Alyssa's three training goals: (1) global health research, (2) implementation science, and (3) adolescent health disparities. Alyssa has assembled an expert mentorship team who will facilitate her engagement in research and training activities. Each month, she will review her progress with Dr. Donenberg to ensure she is on track to meet her deliverables. Taken together, the combination of experiences, close mentorship, and oversight by Dr. Donenberg, Alyssa will receive a strong foundation to prepare her for a future research career.

南非15 - 19岁的少女和年轻妇女（AGYW）面临高风险， 新的性传播感染，包括艾滋病毒。目前正在努力阻止传播， 失望以家庭为基础的预防方案在艾滋病毒预防中未得到充分利用 尽管有证据表明，这些工具包有望改善青年男女的健康预防态度和行为。 这个为期一年的多样性补充将支持Alyssa Debra作为医生科学家的职业发展 她在医学院完成了两年的学业后开始攻读博士学位。她的研究建立在 父母补助，一项检测女性护理者（FC）-女儿HIV/STI的2组随机对照试验 南非AGYW性病和艾滋病毒发病率的预防方案。使用来自母公司的UG 3试点数据 在这项研究中，Alyssa将评估两种理论机制，据信可以解释AGYW STI和HIV的变化 成果：FC-AGYW关系和沟通，以及AGYW艾滋病毒/性传播感染知识、态度， skills. Alyssa将检查这些机制从基线到6个月随访（治疗后）的变化 干预），她将比较实验组和对照组的变化。调查结果将为 评估这些机制对母项目主要和次要成果的作用。 职业发展计划规定了实践经验培训，课程，指导 阅读，与导师一对一的会议，以及实现Alyssa的三个网络机会 培训目标：（1）全球健康研究，（2）实施科学，（3）青少年健康差异。 Alyssa组建了一个专家导师团队，他们将促进她参与研究， 培训活动。每个月，她都会与Donenberg博士一起回顾她的进展，以确保她走上正轨， 满足她的交付要求总的来说，经验，密切的指导和监督相结合， 博士Donenberg，Alyssa将获得坚实的基础，为她未来的研究生涯做好准备。

项目成果

Harmonizing Implementation and Outcome Data Across HIV Prevention and Care Studies in Resource-Constrained Settings.

协调资源有限环境中艾滋病毒预防和护理研究的实施和结果数据。

• DOI: 10.1007/978-3-030-82193-7_42
• 发表时间: 2022
• 期刊: Global implementation research and applications
• 作者: Donenberg GR

An individually randomized controlled trial of a mother-daughter HIV/STI prevention program for adolescent girls and young women in South Africa: IMARA-SA study protocol.

• DOI: 10.1186/s12889-021-11727-3
• 发表时间: 2021-09-20
• 期刊: BMC public health
• 影响因子: 4.5
• 作者: Donenberg GR;Atujuna M;Merrill KG;Emerson E;Ndwayana S;Blachman-Demner D;Bekker LG
• 通讯作者: Bekker LG

Mental health outcomes of a pilot 2-arm randomized controlled trial of a HIV-prevention program for South African adolescent girls and young women and their female caregivers.

• DOI: 10.1186/s12889-021-12010-1
• 发表时间: 2021-11-30
• 期刊: BMC public health
• 影响因子: 4.5
• 作者: Donenberg G;Merrill KG;Atujuna M;Emerson E;Bray B;Bekker LG
• 通讯作者: Bekker LG