Mechanism and Inhibition of Histone Modifications
组蛋白修饰的机制和抑制
基本信息
- 批准号:10621492
- 负责人:
- 金额:$ 37.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-04-01 至 2028-01-31
- 项目状态:未结题
- 来源:
- 关键词:AcetylationArginineBiologicalBiological ProcessBiologyCell physiologyChemicalsCoupledDevelopmentDiabetes MellitusDiseaseDisease PathwayEnzymesEpigenetic ProcessGenetic TranscriptionGoalsInfectionInflammationInvestmentsLaboratory ResearchLysineMalignant NeoplasmsMediatingMetabolic PathwayMetabolismMethodsMethylationMethyltransferaseMolecularMolecular TargetMutateOrganismPathogenesisPathologyPathway interactionsPharmaceutical PreparationsPhysiologyPost-Translational Protein ProcessingProcessProtein IsoformsProtein MethylationProtein MethyltransferasesProtein-Arginine N-MethyltransferaseRNA SplicingRegulationResearchSignal TransductionStructureTranslatingTranslationsdesigndrug discoveryexperimental studyhistone modificationhuman diseaseinnovationmembernervous system disordernovelnovel therapeuticsoverexpressionpathogenprogramsprotein functiontargeted treatmenttherapeutic candidatetherapy developmenttool
项目摘要
Protein methylation on arginine and lysine residues represents a type of versatile posttranslational modifications
occurring in all eukaryotic organisms. Protein methyltransferases regulate a plethora of cellular processes
ranged from gene transcription, RNA splicing, translation, metabolic pathways, to signal transduction. Many
protein methyltransferases are found to be overexpressed or mutated in common human diseases such as
cancer, inflammation, diabetes, neurological disorders, and infection. Hence, protein methyltransferases are
highly promising novel molecular targets in drug discovery. However, biological functions of the majority of
protein methyltransferase enzymes in dictating normal physiology and disease pathways are only poorly defined.
Our long-term research goal is to elucidate biological pathways whereby key protein methyltransferases
contribute to the pathogenesis of recalcitrant diseases such as cancer and infection, and meanwhile to discover
new structural chemotypes for protein methyltransferase-targeted therapy. The present research program is
aimed at investigating molecular mechanisms and functions of protein methylation catalyzed by key
methyltransferases. Our effort is coupled with and aided by development and application of innovative chemical
biology methods and tools. Built upon our recent preliminary results, we will implement experiments to elucidate
novel molecular mechanisms and regulation of protein arginine methyltransferase (PRMT) activities. We will
extend our efforts to investigate the activity, structure and function of untapped protein methyltransferases,
including those in different organisms such as infectious pathogens. Particular efforts will be directed to develop
isoform-selective modulators and probes for important PRMT members and apply them to elucidate PRMT-
regulated cellular pathways and disease processes. Further efforts will be invested to interrogate potential cross-
interactions of protein methylation with lysine acetylation in orchestrating biological regulation. The results of the
proposed research together will yield an in-depth understanding of the regulatory mechanism and biological
significance of protein methylation in the control of normal physiology and disease pathology, and translate
laboratory research leads into therapeutic candidates for the treatment of protein methyltransferase-controlled
ailments.
精氨酸和赖氨酸残基上的蛋白质甲基化代表了一种多用途的翻译后修饰
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Y. George Zheng其他文献
Y. George Zheng的其他文献
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{{ truncateString('Y. George Zheng', 18)}}的其他基金
Develop Potent Methyltransferase Inhibitors to Target Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
开发有效的甲基转移酶抑制剂来治疗严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2)
- 批准号:
10175592 - 财政年份:2021
- 资助金额:
$ 37.3万 - 项目类别:
Mechanism and Inhibition of Protein Arginine Methylation
蛋白质精氨酸甲基化的机制及抑制
- 批准号:
10079491 - 财政年份:2018
- 资助金额:
$ 37.3万 - 项目类别:
Mechanism and Inhibition of Protein Arginine Methylation
蛋白质精氨酸甲基化的机制及抑制
- 批准号:
10392637 - 财政年份:2018
- 资助金额:
$ 37.3万 - 项目类别:
Chemical Approaches to Protein Arginine Methylation
蛋白质精氨酸甲基化的化学方法
- 批准号:
8528619 - 财政年份:2010
- 资助金额:
$ 37.3万 - 项目类别:
Chemical Approaches to Protein Arginine Methylation
蛋白质精氨酸甲基化的化学方法
- 批准号:
7986077 - 财政年份:2010
- 资助金额:
$ 37.3万 - 项目类别:
Chemical Approaches to Protein Arginine Methylation
蛋白质精氨酸甲基化的化学方法
- 批准号:
8324722 - 财政年份:2010
- 资助金额:
$ 37.3万 - 项目类别:
Chemical Approaches to Protein Arginine Methylation
蛋白质精氨酸甲基化的化学方法
- 批准号:
8136011 - 财政年份:2010
- 资助金额:
$ 37.3万 - 项目类别:
Chemical Approaches to Protein Arginine Methylation
蛋白质精氨酸甲基化的化学方法
- 批准号:
8725683 - 财政年份:2010
- 资助金额:
$ 37.3万 - 项目类别:
Chemical Approaches to Protein Arginine Methylation
蛋白质精氨酸甲基化的化学方法
- 批准号:
8693069 - 财政年份:2010
- 资助金额:
$ 37.3万 - 项目类别:
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