Mechanism and Inhibition of Protein Arginine Methylation

蛋白质精氨酸甲基化的机制及抑制

• 批准号: 10392637
• 负责人: Y. George Zheng
• 金额: $ 0.66万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10392637
• 关键词: Administrative Supplement; Area; Arginine; Biomedical Research; Health; Laboratory Research; Methylation; Mission; Pharmacologic Substance; Protein Inhibition; Protein-Arginine N-Methyltransferase; Research; Science; Students; Time; Training; Work; career; career development; drug discovery; experience; interest; next generation; summer research; undergraduate student

Abstract We are submitting an administrative supplement request to support an undergraduate student Julie Nguyen to conduct summer research within the scope of the original project. Ms Nguyen is currently a third year undergraduate student at UGA majored in pharmaceutical science, and this moment is the prime time for her to engage in laboratory research experiences. Ms Nguyen has a demonstrated interest in and desire to pursue research in health-related sciences, especially drug discovery and pharmaceutical science. The PI’s R01 project regarding the mechanism and inhibition of protein arginine methyltransferases (PRMTs) offers an ideal platform for the student to participate in the research area well aligned with her science passion. The supplement support will impact on and add a positive value to the undergraduate’s career development experience.

摘要 我们正在提交一份行政补充申请，以支持一名本科生朱莉 阮在原项目范围内进行夏季研究。阮女士目前是第三年 UGA的本科生主修制药科学，这一刻是她的黄金时间， 有从事实验室研究的经验。阮女士表现出了对追求 与健康相关的科学研究，特别是药物发现和制药科学。PI的R01项目 关于蛋白质精氨酸甲基转移酶（PRMTs）的机制和抑制提供了一个理想的平台 让学生参与研究领域，与她的科学热情保持一致。补充支持 将影响和增加一个积极的价值，以本科生的职业发展经验。

项目成果

Pharmacophore-based screening of diamidine small molecule inhibitors for protein arginine methyltransferases

• DOI: 10.1039/d0md00259c
• 发表时间: 2021-01-01
• 期刊: RSC MEDICINAL CHEMISTRY
• 影响因子: 4.1
• 作者: Qian, Kun;Yan, Chunli;Zheng, Y. George
• 通讯作者: Zheng, Y. George