Regulatory Functions of the Differentiated Epidermis

摘要 表皮形成了与外界的基本屏障。为了实现这一点，它包含 增殖干细胞补充组织，产生分化细胞，形成一个 功能性屏障。我们已经发现，表皮的分化细胞起着重要的作用， 在调节其亲本干细胞的行为中起作用，使它们不仅是细胞的后代， 干细胞，但它们的调节生态位的一部分。此外，机械状态的分化 细胞，即它们的收缩性，是表皮干细胞多个方面的强输入， 行为，包括增殖，迁移和细胞命运的决定。在这里，我们试图定义 途径，机械和化学，由分化的表皮细胞控制， 干细胞行为和皮肤生理学。通过以下方式确定利基组成部分和机制： 它们对表皮干细胞行为的影响对于操纵干细胞至关重要 用于再生疗法和/或治疗由干细胞失调引起的疾病。

Abstract The epidermis forms an essential barrier to the outside world. To accomplish this, it contains proliferative stem cells that replenish the tissue, giving rise to differentiated cells that form a functional barrier. We have found that the differentiated cells of the epidermis play an important role in regulating the behavior of their parental stem cells, making them not only descents of the stem cells but part of their regulatory niche. Moreover, the mechanical status of differentiated cells, namely their contractility, is a strong input into multiple aspects of epidermal stem cell behavior, including proliferation, migration, and cell fate decisions. Here we seek to define the pathways, both mechanical and chemical, by which differentiated epidermal cells control both stem cell behavior and skin physiology. Defining the niche components and the mechanisms by which they influence epidermal stem cell behavior is essential to allow manipulation of stem cells for regenerative therapies and/or treatment of diseases that result from stem cell dysregulation.