Regulatory Functions of the Differentiated Epidermis
Regulatory Functions of the Differentiated Epidermis
批准号:
10620771
负责人:
Terry H Lechler
金额:
$45.37万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
未结题
起止时间:
2022-05-15 至 2027-04-30
关键词:
AblationAdherens JunctionArchitectureAutomobile DrivingBackBasement membraneBehaviorCell AdhesionCell CountCell Differentiation processCellsChemicalsCollaborationsCommunicationCouplingDataDaughterDermisDevelopmentDiseaseEmbryonic DevelopmentEnsureEnvironmental Risk FactorEpidermisFamilyFeedsFunctional disorderGeneticGoalsMechanicsParentsPathway interactionsPlayPopulationProliferatingProteinsPublishingRegulationRoleSignal TransductionSkinSkin PhysiologyStructureTestingThickTissuesWorkWound healing therapycell behaviorcell typedaughter cellembryonic stem cellepidermal stem cellepidermis cellgene functionloss of functionmechanical drivemigrationmouse modelnoveloffspringprotein functionregeneration potentialregenerative biologyregenerative cellregenerative therapyregenerative treatmentresponseskin barrierskin organogenesisstem cell biologystem cell nichestem cell proliferationstem cellstooltranscription factor
中文摘要
摘要
表皮形成了与外界的基本屏障。为了实现这一点,它包含
增殖干细胞补充组织,产生分化细胞,形成一个
功能性屏障。我们已经发现,表皮的分化细胞起着重要的作用,
在调节其亲本干细胞的行为中起作用,使它们不仅是细胞的后代,
干细胞,但它们的调节生态位的一部分。此外,机械状态的分化
细胞,即它们的收缩性,是表皮干细胞多个方面的强输入,
行为,包括增殖,迁移和细胞命运的决定。在这里,我们试图定义
途径,机械和化学,由分化的表皮细胞控制,
干细胞行为和皮肤生理学。通过以下方式确定利基组成部分和机制:
它们对表皮干细胞行为的影响对于操纵干细胞至关重要
用于再生疗法和/或治疗由干细胞失调引起的疾病。
英文摘要
Abstract
The epidermis forms an essential barrier to the outside world. To accomplish this, it contains
proliferative stem cells that replenish the tissue, giving rise to differentiated cells that form a
functional barrier. We have found that the differentiated cells of the epidermis play an important
role in regulating the behavior of their parental stem cells, making them not only descents of the
stem cells but part of their regulatory niche. Moreover, the mechanical status of differentiated
cells, namely their contractility, is a strong input into multiple aspects of epidermal stem cell
behavior, including proliferation, migration, and cell fate decisions. Here we seek to define the
pathways, both mechanical and chemical, by which differentiated epidermal cells control both
stem cell behavior and skin physiology. Defining the niche components and the mechanisms by
which they influence epidermal stem cell behavior is essential to allow manipulation of stem cells
for regenerative therapies and/or treatment of diseases that result from stem cell dysregulation.
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专著(0)
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会议论文
Translational Regulation by Desmosomes
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批准号:10314319
-
项目类别:
-
资助金额:$38.96万
-
财政年份:2021
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负责人:Terry H Lechler
-
依托单位:
Intermediate Cell Functions in Epidermal Development
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批准号:9770766
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项目类别:
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资助金额:$20.65万
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财政年份:2018
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负责人:Terry H Lechler
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依托单位:
Intestinal Morphogenesis and Differentiation
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批准号:10198916
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项目类别:
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资助金额:$36.23万
-
财政年份:2018
-
负责人:Terry H Lechler
-
依托单位:
Intermediate Cell Functions in Epidermal Development
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批准号:9585148
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项目类别:
-
资助金额:$17.05万
-
财政年份:2018
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负责人:Terry H Lechler
-
依托单位:
Spindle Orientation in Skin Development and Homeostasis
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批准号:9118867
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项目类别:
-
资助金额:$33.91万
-
财政年份:2015
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负责人:Terry H Lechler
-
依托单位:
Spindle Orientation in Skin Development and Homeostasis
-
批准号:10474961
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项目类别:
-
资助金额:$45.4万
-
财政年份:2015
-
负责人:Terry H Lechler
-
依托单位:
Spindle Orientation in Skin Development and Homeostasis
-
批准号:9761985
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项目类别:
-
资助金额:$33.78万
-
财政年份:2015
-
负责人:Terry H Lechler
-
依托单位:
Differentiation Induced Changes in Centrosomes and Microtubule Organization
-
批准号:9324271
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项目类别:
-
资助金额:$29.77万
-
财政年份:2014
-
负责人:Terry H Lechler
-
依托单位:
Differentiation Induced Changes in Centrosomes and Microtubule Organization
-
批准号:8747193
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项目类别:
-
资助金额:$29.46万
-
财政年份:2014
-
负责人:Terry H Lechler
-
依托单位:
Differentiation Induced Changes in Centrosomes and Microtubule Organization
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批准号:9121588
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项目类别:
-
资助金额:$29.78万
-
财政年份:2014
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负责人:Terry H Lechler
-
依托单位:
Mechanisms Driving Asymmetric Cell Division in the Epidermis
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批准号:8153319
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项目类别:
-
资助金额:$7.49万
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财政年份:2011
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负责人:Terry H Lechler
-
依托单位:
Mechanisms Driving Asymmetric Cell Division in the Epidermis
-
批准号:7895763
-
项目类别:
-
资助金额:$7.8万
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财政年份:2009
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负责人:Terry H Lechler
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依托单位:
Desmosomal Control of Cytoskeletal Organization
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批准号:7899888
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项目类别:
-
资助金额:$34.75万
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财政年份:2009
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负责人:Terry H Lechler
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依托单位:
Desmosomal Control of Cytoskeletal Organization
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批准号:7740910
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项目类别:
-
资助金额:$31.14万
-
财政年份:2009
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负责人:Terry H Lechler
-
依托单位:
Desmosomal Control of Cytoskeletal Organization
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批准号:8510573
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项目类别:
-
资助金额:$31.69万
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财政年份:2009
-
负责人:Terry H Lechler
-
依托单位:
Desmosomal Control of Cytoskeletal Organization
-
批准号:8303015
-
项目类别:
-
资助金额:$33.36万
-
财政年份:2009
-
负责人:Terry H Lechler
-
依托单位:
Desmosomal Control of Cytoskeletal Organization
-
批准号:8117121
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项目类别:
-
资助金额:$33.36万
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财政年份:2009
-
负责人:Terry H Lechler
-
依托单位:
Role of Cell Adhesion and the Cytoskeleton in Epidermal Integrity
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批准号:9243590
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项目类别:
-
资助金额:$18.74万
-
财政年份:2009
-
负责人:Terry H Lechler
-
依托单位:
Mechanisms Driving Asymmetric Cell Division in the Epidermis
-
批准号:7573346
-
项目类别:
-
资助金额:$7.8万
-
财政年份:2009
-
负责人:Terry H Lechler
-
依托单位:
Role of Cell Adhesion and the Cytoskeleton in Epidermal Integrity
-
批准号:8961762
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项目类别:
-
资助金额:$33.97万
-
财政年份:2009
-
负责人:Terry H Lechler
-
依托单位:
海外基金