DYNAMICS AND EVOLUTION OF IMMUNE RESPONSES TO INFLUENZA VIRUSES

流感病毒免疫反应的动态和演变

基本信息

  • 批准号:
    10621337
  • 负责人:
  • 金额:
    $ 114.6万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-06-29 至 2025-05-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT Our goal is to develop a quantitative framework for the generation, boosting and maintenance of immunological memory. Mathematical models are useful because immunization and infection involve the interaction of rapidly changing populations of virus and multiple populations of immune cells. We first develop and validate models using experiments in mice. We then use these validated models to analyze data from human vaccination studies. Aim 1 asks how prior immunity affects and potentially limit the boosting of immunity and apply this to influenza. Our approach is to develop models to understand why prior immunity limits boosting of antibodies to conserved regions of the virus. Specifically, we use our models to better understand how prior immunity might limit boosting of antibody responses to conserved regions on the stem of the hemagglutinin molecule that is the focus of universal influenza vaccines. Aim 2 considers the factors that affect the durability of humoral immune memory, and address questions such as why memory generated by immunization with protein antigens is less durable than immunity generated by virus infection, and how prior immunity can differentially affect the boosting and generation of memory to new strains of influenza. Aim 3 considers the generation of CD8 T cell memory to influenza and yellow fever. We will determine how repeated exposure to influenza affects the diversity of the CD8 T cell responses generated. We have access to a unique dataset that follows the number of YFV-specific CD8 T cells, changes in their phenotype, and their turnover from heavy water labelling studies for a period of over one year. Our analysis of this dataset will allow us to address an ongoing controversy regarding whether are long-term memory CD8 memory stem cells are generated rapidly after immunization or only gradually over time. Aim 4 describes computational tools that we will build for B cell receptor sequence analysis and visualization, and for simulation of the dynamics of immune responses. These tools will be widely accessible online, and promoted at workshops and scientific symposia we organize.
项目总结/文摘

项目成果

期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Longitudinal Assessment of Immune Responses to Repeated Annual Influenza Vaccination in a Human Cohort of Adults and Teenagers.
  • DOI:
    10.3389/fimmu.2021.642791
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    7.3
  • 作者:
    Sung MH;Shen Y;Handel A;Bahl J;Ross TM
  • 通讯作者:
    Ross TM
Use of Patient-Reported Symptom Data in Clinical Decision Rules for Predicting Influenza in a Telemedicine Setting.
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RUSTOM NOSHIR ANTIA其他文献

RUSTOM NOSHIR ANTIA的其他文献

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{{ truncateString('RUSTOM NOSHIR ANTIA', 18)}}的其他基金

DYNAMICS AND EVOLUTION OF IMMUNE RESPONSES TO INFLUENZA VIRUSES
流感病毒免疫反应的动态和演变
  • 批准号:
    10407514
  • 财政年份:
    2020
  • 资助金额:
    $ 114.6万
  • 项目类别:
DYNAMICS AND EVOLUTION OF IMMUNE RESPONSES TO INFLUENZA VIRUSES
流感病毒免疫反应的动态和演变
  • 批准号:
    10204919
  • 财政年份:
    2020
  • 资助金额:
    $ 114.6万
  • 项目类别:
Dynamics and Evolution of Immune Responses to Influenza Viruses
流感病毒免疫反应的动态和进化
  • 批准号:
    8895033
  • 财政年份:
    2015
  • 资助金额:
    $ 114.6万
  • 项目类别:
Dynamics and Evolution of Immune Responses to Influenza Viruses
流感病毒免疫反应的动态和进化
  • 批准号:
    9238642
  • 财政年份:
    2015
  • 资助金额:
    $ 114.6万
  • 项目类别:
QUANTIFYING THE BALANCE BETWEEN VACCINE-INDUCED T CELL PROTECTION AND PATHOLOGY
量化疫苗诱导的 T 细胞保护与病理学之间的平衡
  • 批准号:
    8793097
  • 财政年份:
    2014
  • 资助金额:
    $ 114.6万
  • 项目类别:
QUANTIFYING THE BALANCE BETWEEN VACCINE-INDUCED T CELL PROTECTION AND PATHOLOGY
量化疫苗诱导的 T 细胞保护与病理学之间的平衡
  • 批准号:
    8997058
  • 财政年份:
    2014
  • 资助金额:
    $ 114.6万
  • 项目类别:
QUANTIFYING THE BALANCE BETWEEN VACCINE-INDUCED T CELL PROTECTION AND PATHOLOGY
量化疫苗诱导的 T 细胞保护与病理学之间的平衡
  • 批准号:
    8674042
  • 财政年份:
    2014
  • 资助金额:
    $ 114.6万
  • 项目类别:
QUANTIFYING THE BALANCE BETWEEN VACCINE-INDUCED T CELL PROTECTION AND PATHOLOGY
量化疫苗诱导的 T 细胞保护与病理学之间的平衡
  • 批准号:
    9204367
  • 财政年份:
    2014
  • 资助金额:
    $ 114.6万
  • 项目类别:
Quantititive models of CD8+ immune memory
CD8免疫记忆的定量模型
  • 批准号:
    6320146
  • 财政年份:
    2001
  • 资助金额:
    $ 114.6万
  • 项目类别:
Quantitative models of CD8+ T-cell memory
CD8 T 细胞记忆的定量模型
  • 批准号:
    7558509
  • 财政年份:
    2001
  • 资助金额:
    $ 114.6万
  • 项目类别:

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