Novel pathways involving APC and PAR-2 in cartilage degradation in osteoarthritis

涉及 APC 和 PAR-2 参与骨关节炎软骨降解的新途径

• 批准号: nhmrc : 570921
• 负责人: Prof Christopher Jackson
• 金额: $ 29.93万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-pathways-involving-degradation-osteoarthritis/99060
• 关键词: Novel; pathways; involving; APC; PAR

Loss of the cartilage that normally lines the ends of bones is central to joint failure in arthritis and the need for replacement surgery. There are presently no treatments that stop cartilage breakdown in joint disease. This project investigates the role of a new pathway not previously thought to be active in cartilage, in the progressive damage seen in arthritis. Successful completion of these studies may provide a novel new strategy to treat joint disease.

软骨的损失，通常线的两端骨是中央关节炎关节衰竭和需要更换手术。目前还没有治疗方法可以阻止关节疾病中的软骨破坏。该项目研究了一种以前认为在软骨中不活跃的新途径在关节炎中观察到的进行性损伤中的作用。这些研究的成功完成可能为治疗关节疾病提供一种新的新策略。