Home-based cardiac rehabilitation using a novel mobile health exercise regimen following transcatheter heart valve interventions (HOME RUN HITTER)

经导管心脏瓣膜介入治疗后使用新型移动健康锻炼方案进行家庭心脏康复（全垒打）

• 批准号: 10623250
• 负责人: Brian Richard Lindman
• 金额: $ 75.39万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10623250
• 关键词: Activities of Daily Living; Address; Aorta; Apple watch; Behavioral Mechanisms; Behavioral Sciences; Cardiac Surgery procedures; Cardiac rehabilitation; Cardiovascular Diseases; Cessation of life; Clinical; Complement; Counseling; Disease; Elderly; Equilibrium; Event; Exercise; Exercise Physiology; Future; Geriatrics; Goals; Habits; Hand; Health Technology; Health behavior; Heart Valve Diseases; Heart Valves; Home; Hospitalization; Individual; Intervention; Learning; Measures; Mediator; Medicare; Mobile Health Application; Monitor; Morbidity - disease rate; Operative Surgical Procedures; Outcome; Participant; Patient Participation; Patient-Focused Outcomes; Patients; Physical activity; Pilot Projects; Prevalence; Procedures; Quality of life; Randomized; Randomized, Controlled Trials; Recovery; Registries; Research Design; Running; Safety; Skilled Nursing Facilities; Social support; Specific qualifier value; Subgroup; Testing; Translations; Visit; Walking; Work; aging population; aortic valve; behavior change; beneficiary; care outcomes; clinically relevant; clinically significant; comparison control; design; digital tool; efficacy/implementation trial; exercise physiologist; exercise prescription; exercise regimen; fitbit; group intervention; home test; hospital readmission; improved; infancy; innovation; mHealth; mortality; multidisciplinary; novel; participant enrollment; patient population; pilot trial; primary endpoint; programs; repaired; secondary endpoint; success; therapy design; trial enrollment; video chat; virtual intervention

Among older adults, heart valve disease is common and often requires treatment with valve repair or replacement. What used to require open heart surgery can now be done with less invasive transcatheter heart valve interventions (THVIs), allowing for less morbidity and quicker recovery. However, despite the safety and procedural success of THVIs, over one-half of patients are dead, have poor quality of life (QoL), and/or are hospitalized 1 year after a THVI. Cardiac rehabilitation (CR) effectively mitigates these poor outcomes in patients with cardiovascular disease, including those undergoing heart valve procedures. However, among Medicare beneficiaries, only 25% of those undergoing a THVI participate in center-based CR (CBCR), which highlights a significant unmet clinical need. To address this need, our long-term goal is to develop a home- based CR (HBCR) program that extends the benefits of CR to more individuals after THVIs. Our over-arching hypothesis is that a HBCR mobile health intervention that innovatively addresses key target health behaviors will reduce clinical events and improve physical activity, functional capacity, and QoL after THVIs and that an interactive delivery and longer duration of the active intervention will produce greater benefits. We propose a multicenter randomized controlled trial enrolling 375 patients undergoing aortic or mitral THVIs who do not intend to participate in CBCR; those who intend to pursue CBCR will be followed in a registry. Participants will be assigned to 3 groups: control (1) vs. a HBCR mobile health intervention with hands-off (2) vs. interactive (3) delivery. The intervention addresses key target health behaviors and includes Apple Watch (to encourage physical activity and give reminders on healthy living) and an exercise prescription (to build strength/balance). The hands-off and interactive delivery groups receive the same intervention, except for a video call (every other week) with an exercise physiologist (interactive group only). Each intervention group (hands-off, interactive) will be randomized to 12-week vs. 24-week duration of the active intervention. The co-primary endpoints are: (1) clinical events composite (death, rehospitalization, skilled nursing facility visits); and (2) average daily total activity counts. Key secondary endpoints: amount, intensity, consistency of physical activity; 6-minute walk distance; and QoL. We test whether the HBCR mobile health intervention (compared to control) reduces clinical events and improves physical activity, function capacity, and QoL after THVI (Aim 1) and whether interactive vs. hands-ff delivery (Aim 2) or 24-week vs. 12-week active duration (Aim 3) of the intervention yields greater benefits. We also explore mediators of clinical benefit and mechanisms of behavior change. With population aging, prevalence of heart valve disease and number of THVIs are rapidly increasing. Overcoming disablement associated with severe valve disease requires more than simply fixing a valve; the potential of THVIs to improve quantity and quality of life is unfulfilled without integrating CR. If successful, our approach will optimize value of care and patient outcomes with broad implications for other patient populations.

在老年人中，心脏瓣膜疾病很常见，通常需要进行瓣膜修复或手术治疗