Increasing Meaning to Reduce Loneliness in Care Partners of Persons with AD/ADRD

减少 AD/ADRD 患者护理伙伴的孤独感越来越重要

• 批准号: 10624320
• 负责人: Allison Marziliano
• 金额: $ 12.35万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10624320
• 关键词: Address; Alzheimer' s Disease; Alzheimer' s disease patient; Alzheimer' s disease related dementia; Anxiety; Burn injury; Caring; Consent; Disease; Distress; Doctor of Philosophy; Dropout; Education; Elderly; Evidence based intervention; Exercise; Feedback; Feeling; Focus Groups; Future; Genetic Transcription; Goals; Group Meetings; Group Psychotherapy; Health; Individual; Instruction; Intervention; Interview; Learning; Life; Link; Loneliness; Malignant Neoplasms; Malignant neoplasm of urinary bladder; Meaning and purpose; Mental Depression; Mentors; Mentorship; Methodology; Methods; Morbidity - disease rate; Myocardial Infarction; National Institute on Aging; Outcome; Pain; Participant; Patients; Persons; Phase; Population; Psyche structure; Psychotherapy; Public Health; Published Comment; Randomized; Reading; Reporting; Research; Research Design; Research Personnel; Social Workers; Stroke; Suggestion; System; Technology; Testing; Theoretical model; Thinking; Training; Vertebral column; Video Recording; Work; Writing; age related; cancer care; career; dementia care; design; effective intervention; experience; improved; innovation; intervention delivery; meetings; member; mortality risk; programs; statistics; success; treatment arm; treatment as usual; usability; virtual group; web platform; web-based intervention

During the K01 period, I will fill critical gaps in my training through meeting 6 training goals: 1) advance my understanding of the experiences of persons with Alzheimer’s Disease (AD) and AD-related dementias (ADRD), their care partners and older adults (co-mentor: Edith Burns, MD); 2) gain expertise in theoretical models of loneliness (team member: Louise Hawkley, PhD); 3) advance my understanding of psychotherapies (team member: Allison Applebaum, PhD); 4) leveraging technology to deliver interventions (primary mentor: Michael Diefenbach, PhD); 5) learning advanced study designs, methodologies, and statistics (co-mentor: Martin Lesser, PhD); and 6) engage in in-depth training needed to maintain a successful program of research (Diefenbach). These training goals and expert mentorship were designed in support of my overall career goal of becoming an independent investigator improving the lives of older adults and their care partners through reduction of loneliness. More than 60% of care partners of persons with AD/ADRD report feeling lonely. Building on the existing evidence that increasing meaning and purpose in life is a strong predictor of decreased loneliness, interventions to reduce loneliness in this population may be strengthened by incorporating concepts from Meaning-Centered Psychotherapy (MCP). Thus, the overall goal of the proposed project is to reduce loneliness in care partners of patients with AD/ADRD through increasing their sense of meaning and purpose in life using concepts from MCP, delivered via a web-based platform, RELOAD-C (REducing LOneliness in Alzeheimer’s Disease-Care Partners). This will be achieved through three Specific Aims. Aim 1 consists of three phases (preparatory work, stakeholder involvement with N=15 AD/ADRD care partners, and adaptation of the existing web-based platform) to produce RELOAD-C, which centralizes: 1) 6 brief videos portraying our MCP expert delivering MCP concepts; 2) links to 7 virtual group meetings (6 weekly + 1 booster) to discuss MCP concepts; and 3) written content expanding on the material from the MCP videos. Aim 2 evaluates usability/acceptability of RELOAD-C (defined as a task success rate ≥ 78%, and scores ≥ 68 on the System Usability Scale) with N=20 care partners of persons with AD/ADRD. Aim 3 proposes a pilot RCT to evaluate the preliminary efficacy of the RELOAD-C components (MCP videos vs. MCP-focused group discussions) in reducing loneliness and feasibility of conducting a future, large-scale RCT. N=96 AD/ADRD care partners will be randomized to: usual care, n=32; MCP videos alone via RELOAD-C, n=32; or MCP videos + weekly groups via RELOAD-C, n=32. Care partners’ outcomes will be assessed at baseline, and 6-weeks and 3-months post- baseline. We expect the effect sizes will be in the moderate range (.3). Feasibility is defined as: ≥ 75% consented, ≤ 30% drop-out, and 80% engagement with intervention. Reducing loneliness among care partners is of high public health significance and incorporating MCP in loneliness interventions is highly innovative.

在K01期间，我将通过完成6个培训目标来填补培训中的关键空白：1)提高我的水平