Genetics and Genomics Training Grant

遗传学和基因组学培训补助金

• 批准号: 10623232
• 负责人: ALLISON E ASHLEY-KOCH
• 金额: $ 53.05万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10623232
• 关键词: Genetic; Genomics; Grant; Training

The University Program in Genetics and Genomics (UPGG) has a nearly 40-year history of training graduate students at Duke University. The program has maintained its status over the years as an elite graduate training program by co-evolving with changes in experimental and analytical technologies, scientific culture, career development, and student demographics. Currently, the UPGG is a degree- granting program of approximately 50 students and 90 faculty with appointments in departments across the School of Medicine, School of Engineering, and Arts & Sciences. UPGG students have the opportunity to train in a broad range of fundamental research questions including chromosomes, nucleic acids, and gene expression; developmental genetics, population and evolutionary genetics; model systems genetics, human and mammalian genetics, plant genetics; and microbial and viral genetics. Our faculty train students in experimental and quantitative/analytical approaches across a variety of biological systems from microbes to plants to humans. This intellectual diversity, coupled with Duke’s highly collaborative culture, has created a truly interdisciplinary training environment. Our UPGG alumni populate a breadth of career paths from traditional academic research and teaching to industrial/government research or regulatory affairs, and small startup companies to big pharma. Our current trainees come from a variety of scientific, cultural, and socioeconomic backgrounds. This diverse population participates actively in their own training by organizing some of our signature programs, such as the annual student retreat, distinguished lecture series, and community outreach efforts. Additional programmatic offerings such as our Tuesday Seminar Series serve as a focal point for bringing together the entire Genetics and Genomics community together at Duke. In the coming grant period, we seek to leverage the current strengths and successes of the UPGG along with developing new programmatic and curricular offerings that support the intellectual and career development of our trainees. Our objective is to utilize the backdrop of genetics and genomics research at Duke to produce independent scientists who are well trained in the fundamental technical, leadership, and operational skills necessary for them to thrive in a range of scientific career paths. As part of our focus on student training, we will develop mechanisms for improving the mentoring skills of our training faculty who play a critical role in the intellectual development of our trainees. Finally, we will ensure that our training environment continues to be one in which all of our students can flourish.

遗传学和基因组学大学项目(UPGG)已有近40年的培训历史 杜克大学的研究生。多年来，该项目一直保持着精英的地位 研究生培训计划，通过与实验和分析技术的变化共同发展， 科学文化、职业发展和学生人口统计。目前，UPGG是一个学位- 授予约50名学生和90名教职员工的计划，并在各部门进行预约 医学院、工程学院和文理学院。UPGG学生拥有 有机会在广泛的基础研究问题上进行培训，包括染色体， 核酸和基因表达；发育遗传学、种群和进化遗传学； 模式系统遗传学、人类和哺乳动物遗传学、植物遗传学；以及微生物和病毒 遗传学。我们的教员在实验和定量/分析方法方面对学生进行培训 从微生物到植物再到人类的各种生物系统。这种智力的多样性，再加上 杜克大学高度协作的文化，创造了一个真正的跨学科培训环境。我们的升级版 校友的职业道路从传统的学术研究和教学到 工业/政府研究或监管事务，从小型初创公司到大型制药公司。我们的 目前的学员来自不同的科学、文化和社会经济背景。这 不同的人群通过组织我们的一些签名来积极参与他们自己的培训 计划，如一年一度的学生静修、杰出系列讲座和社区推广 努力。其他课程，如我们的周二研讨会系列，将作为焦点 将整个遗传学和基因组学社区聚集在杜克大学。在即将到来的时候 在授权期内，我们寻求利用UPGG目前的优势和成功，以及 开发新的课程和课程，支持智力和职业生涯 我们实习生的发展。我们的目标是利用遗传学和基因组学研究的背景 在杜克大学培养出在基础技术方面训练有素的独立科学家， 领导力和操作技能是他们在一系列科学的职业道路上茁壮成长所必需的。AS 作为我们对学生培训的关注的一部分，我们将制定机制来提高 我们的培训教师对学员的智力发展起着至关重要的作用。最后，我们会 确保我们的培训环境继续成为我们所有学生都能茁壮成长的环境。

项目成果

Mechanism of commitment to a mating partner in Saccharomyces cerevisiae.

• DOI: 10.1091/mbc.e22-02-0043
• 发表时间: 2022-10-01
• 期刊: MOLECULAR BIOLOGY OF THE CELL
• 影响因子: 3.3
• 作者: Jacobs, Katherine C.;Gorman, Olivia;Lew, Daniel J.
• 通讯作者: Lew, Daniel J.

Genome-wide screen identifies host loci that modulate Mycobacterium tuberculosis fitness in immunodivergent mice.

• DOI: 10.1093/g3journal/jkad147
• 发表时间: 2023-08-30
• 期刊: G3-GENES GENOMES GENETICS
• 影响因子: 2.6
• 作者: Meade, Rachel K.;Long, Jarukit E.;Jinich, Adrian;Rhee, Kyu Y.;Ashbrook, David G.;Williams, Robert W.;Sassetti, Christopher M.;Smith, Clare M.
• 通讯作者: Smith, Clare M.

Pheromone Guidance of Polarity Site Movement in Yeast.

• DOI: 10.3390/biom12040502
• 发表时间: 2022-03-26
• 期刊: Biomolecules
• 影响因子: 5.5

Human genetic diversity regulating the TLR10/TLR1/TLR6 locus confers increased cytokines in response to Chlamydia trachomatis.

• DOI: 10.1016/j.xhgg.2021.100071
• 发表时间: 2022-01-13
• 期刊: HGG advances
• 作者: Barnes AB;Keener RM;Schott BH;Wang L;Valdivia RH;Ko DC
• 通讯作者: Ko DC

Cell-type specific transcriptional adaptations of nucleus accumbens interneurons to amphetamine.

• DOI: 10.1038/s41380-022-01466-1
• 发表时间: 2023-08
• 期刊: MOLECULAR PSYCHIATRY
• 影响因子: 11
• 作者: Gallegos, David A.;Minto, Melyssa;Liu, Fang;Hazlett, Mariah F.;Yousefzadeh, S. Aryana;Bartelt, Luke C.;West, Anne E.
• 通讯作者: West, Anne E.