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Mammalian bile acid detection, processing, and impact on social behavior

哺乳动物胆汁酸检测、处理及其对社会行为的影响

基本信息

批准号：
10623267
负责人：
Julian P Meeks
金额：
$ 42.57万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10623267
关键词：
Accessory Olfactory Bulbs Afferent Neurons Animals Anxiety Area Behavior Behavior assessment Behavioral Behavioral Paradigm Bile Acid Biosynthesis Pathway Bile Acids Biochemical Biological Brain Brain imaging Brain region Calcium Cells Chemicals Cholesterol Chromosome Mapping Complement Coprophagia Coupled Cues Data Dedications Detection Diet Dietary Fats Digestion Disease Environment Esthesia Evolution Excretory function Family Fatty acid glycerol esters Feces Foundations G-Protein-Coupled Receptors GPBAR1 gene Gene Expression Glucocorticoids Goals Health Human Image Imaging Techniques Immediate-Early Genes In Situ Hybridization Individual Kairomones Knowledge Laboratories Learning Life Link Liver Mammals Maternal Behavior Measures Metabolic Metabolism Methods Moods Mus Neurons Nose Olfactory Pathways Pattern Peripheral Pheromone Physiology Population Positioning Attribute Process Production Property Reproduction Reproductive Behavior Research Research Proposals Rodent Rodent Control Role Sensory Sensory Receptors Signal Transduction Social Behavior Source Steroids Sulfate Techniques Testing Urine Vitamins absorption behavioral response brain pathway experimental study gut microbes improved information processing insight microorganism mitral cell neural circuit neuromechanism next generation receptor reproductive sensory system sex social anxiety transcriptome transcriptome sequencing urinary vomeronasal organ

项目摘要

Project Summary/Abstract The overall goal of this research plan is to improve understanding about mammalian bile acid chemosignaling through the accessory olfactory system (AOS). Bile acids – well known regulators of fat digestion and metabolism – also serve as external chemosignals for the AOS. In most mammals, the AOS directly influences brain regions that control anxiety and social behaviors, and understanding this brain pathway is likely to provide insights into mammalian sexual/reproductive drive, social anxiety, and moods. New knowledge about AOS function may be utilized to help control rodent populations, including those that harbor harmful microorganisms. The mechanisms of peripheral bile acid sensation, the mechanisms of bile acid information processing in the brain, and the behavioral impacts of bile acids are currently unknown. The proposed research will combine new calcium imaging techniques with transcriptome analysis to identify the peripheral AOS receptor(s) sensitive to bile acids. Other proposed experiments will investigate network properties in accessory olfactory bulb (AOB), where bile acid and other steroid information is integrated. Finally, behavioral assessment will be coupled to brain-wide immediate early gene mapping to determine the overall impacts of bile acid chemosensation on brain activity and behavior. The proposed research will investigate these topics in order to improve understanding of this important class of mammalian chemosignals. The results of the proposed experiments will ultimately benefit human health by linking mammalian gut physiology to brain function.

项目总结/文摘