Molecular mechanisms that control polarity and asymmetric cell division

控制极性和不对称细胞分裂的分子机制

• 批准号: 10623839
• 负责人: Kenneth E Prehoda
• 金额: $ 39.67万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10623839
• 关键词: Animal Organ; Animals; Area; Brain; Cell Line; Cell division; Cell membrane; Cell physiology; Cells; Complex; Disease; Environment; Gastrointestinal tract structure; Malignant Neoplasms; Membrane; Molecular; Neurons; Nutrient; Process; Proteins; Rest; Set protein; Side; Skin; Structure; Time; Tissues; Translating; Work; animal tissue; cell type; human disease; improved; polarized cell

Project Abstract Animal cells are asymmetric, often containing different proteins at distinct areas of the membrane. For example, the cells that line our digestive tract are poised to take in nutrients from one side of the cell and deliver them to the rest of the body at the other side. This proposal examines the activity of the Par complex, a set of proteins responsible for creating and maintaining different regions of animal cell membranes. We are also examining how cellular asymmetries are translated into the complex organization seen in animal tissues and organs. One mechanism for creating structure within tissues is to create different cell types, such as neurons with the brain. In general, our work aims to understand how cells process information to specifically target polarity and fate determinants to the appropriate region of the cell at the right time, activate these complexes once they're localized, and how the activity of these complexes is translated into complex cellular functions, such as differentiation.

项目摘要 动物细胞是不对称的，通常在细胞的不同区域含有不同的蛋白质。 膜的例如，排列在我们消化道上的细胞随时准备吸收营养 从细胞的一侧传递到身体的另一侧。这项建议 研究了Par复合物的活性，Par复合物是一组负责创造和 维持动物细胞膜的不同区域。我们也在研究细胞 动物组织和器官中的复杂组织结构也体现了这种不对称。 在组织内创建结构的一种机制是创建不同的细胞类型，例如 神经元与大脑总的来说，我们的工作旨在了解细胞如何处理信息， 将极性和命运决定因子特异性地定位于右侧细胞的适当区域 时间，一旦这些复合物被定位就激活它们，以及这些复合物的活动如何 转化为复杂的细胞功能，如分化。