Excited-State Catalysis in Organic Synthesis
有机合成中的激发态催化
基本信息
- 批准号:10623174
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-08-05 至 2023-06-30
- 项目状态:已结题
- 来源:
- 关键词:AccelerationAddressAgrochemicalsBiocompatible MaterialsBioprobeCarbohydratesCatalysisChemicalsComplexDerivation procedureDevelopmentDyesGoalsHydrocarbonsInhalatorsLifeLubricantsNatural ProductsOrganic SynthesisOrganometallic CompoundsOxidation-ReductionPesticidesPharmacologic SubstancePolymersPreparationProcessReactionReagentResearchSiteTechnologyTherapeuticVisible Radiationcarbonyl compoundcatalystdrug developmentdrug discoveryhealth care qualityimaging agentimprovednovelnovel therapeuticspropellantsugar
项目摘要
Project Summary/Abstract
Our research goal is to develop new catalytic technologies for the rapid synthesis and late-stage
functionalization under mild reaction conditions of complex, biorelevant molecules. Our research efforts have
been directed to exploit visible-light-induced excited-state catalysis, a process that involves at least one
photoexcited catalytic species, to address unmet challenges in organic synthesis. Excited-state catalysis involves
the photoexcitation of catalytic organic or organometallic compounds that allows access to their excited-state
landscapes for the development of previously elusive synthetic transformations. This proposal aims to continue
our efforts in establishing novel excited-state catalytic platforms for the synthesis of valuable fluorinated
compounds, the derivatization of carbonyl moieties, and the site-selective functionalization of carbohydrates.
More specifically, we will develop (i) polyfluoroalkoxylation reactions of various hydrocarbons via excited-state
catalysis; (ii) new redox-active reagents such as those that can be used for pentafluorosulfenylation and
fluorosulfonylation; (iii) regioselective polyfluoroalkoxylation reactions of arenes and heteroarenes through
metallaphotocatalysis; (iv) new excited-state catalysts to modulate the reactivity of carbonyl compounds; and (v)
site-selective functionalization of carbohydrates. Since fluorinated compounds, carbonyl derivatives, and
functionalized sugars are ubiquitous in natural products, therapeutics, imaging agents, fine chemicals, and
biomaterials, successful development of the proposed research will allow convenient access to and the studies of
numerous new functional molecules to aid the discovery and development of new drugs, agrochemicals, bio-
probes, and polymers.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ming-Yu Ngai其他文献
Ming-Yu Ngai的其他文献
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{{ truncateString('Ming-Yu Ngai', 18)}}的其他基金
Novel Strategies and Reagents for Introduction of Fluorinated Groups
引入氟化基团的新策略和试剂
- 批准号:
9893169 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Novel Strategies and Reagents for Introduction of Fluorinated Groups
引入氟化基团的新策略和试剂
- 批准号:
9326317 - 财政年份:2016
- 资助金额:
-- - 项目类别:
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