Mentoring Emerging Scientists for Careers in Substance Use Research

摘要 这是加州大学旧金山分校弗朗西斯科的一份延期申请，要求延长一项为期五年的研究 临床研究人员的教育计划（成瘾和多样性早期职业学习-LEAD）。的 该计划继续其使命，提供培训，以早期阶段的研究科学家从代表性不足 种族/少数民族群体，旨在增加进行行为的种族/少数民族的数量， 或药物使用障碍治疗研究。国际环境与发展学院建立在国家 药物滥用治疗临床试验网络（CTN），一个由科学家和医疗保健组织组成的网络， 为科学疗法的多点测试提供了广泛的基础设施。在未来五年内，我们将 扩大招聘范围，包括博士后研究员（而不仅仅是助理教授级别的参与者）， 努力接触更多有前途的早期研究人员。培训计划将包括一个新的 实施科学培训的组成部分，以使学者的研究技能与 NIDA CTN的优先事项是在初级保健和其他一般医疗领域进行严格的多地点临床试验 设置.该培训计划极大地受益于与培训计划和教师的紧密联系 在UCSF进行临床研究以及UCSF临床和转化科学的存在 院具体目标是：1）将实习学者与CTN的资深科学家配对，后者将提供 科学指导和专业指导; 2）为学者提供支持，以开展试点研究， 后续NIH应用程序的途径; 3）帮助学者发展赠款写作技能，目标是 在LEAD培训期间提交竞争性NIH申请; 4）提供文化定制培训， 循证治疗和实施研究方法; 5）为学者提供知识， 解决临床试验中遇到的伦理、法规和项目管理问题的技能;以及6）培养 建立网络结构，与物质使用障碍临床试验方面的领先专家建立关系 research.学者将参加为期3年的培训，包括每年为期4周的夏季强化课程 研讨会和讲习班在加州大学旧金山分校，指导和培训在学年，并参与 CTN国家研究和培训会议。学者将与NIDA CTN高级研究员匹配 在三年的培训期间指导他们。成功获得NIH研究或职业奖 发展是参与该计划的学者计划的可衡量成果。程序 解决了对具有文化能力物质使用专业知识的调查人员的需求 有可能影响医疗保健政策和实践的疾病治疗研究。远景目标 增加来自代表性不足的种族/少数民族群体的PI的数量， 疾病治疗研究。

ABSTRACT This is a renewal application from the University of California, San Francisco to extend a five-year research education program for clinical researchers (Learning for Early Careers in Addiction and Diversity-LEAD). The program continues its mission to provide training to early-stage research scientists from underrepresented racial/ethnic minority groups, aiming to increase the number of racial/ethnic minorities who conduct behavioral or pharmacological substance use disorders treatment research. LEAD builds on the platform of the National Drug Abuse Treatment Clinical Trials Network (CTN), a network of scientists and healthcare organizations that offers a broad infrastructure for multisite testing of science-based therapies. During the next five years, we will expand recruitment to include postdoctoral fellows (rather than just assistant professor level participants) in an effort to reach a larger pool of promising early stage investigators. The training program will include a new component in implementation science training to align and strengthen scholars' research skills with the priorities of the NIDA CTN to conduct rigorous multisite clinical trials in primary care and other general medical settings. The training program greatly benefits from strong connections to training programs and faculty conducting clinical research at UCSF and the presence of the UCSF Clinical and Translational Science Institute. Specific aims are to: 1) Match trainee scholars with senior scientists in the CTN who will provide scientific mentoring and professional guidance; 2) provide scholars with support to conduct pilot research as a pathway to subsequent NIH applications; 3) assist scholars in developing grant-writing skills, with the goal of submitting competitive NIH applications during the LEAD training period; 4) offer training in cultural tailoring of evidence-based treatments and implementation research methods; 5) provide scholars with knowledge and skills to address ethical, regulatory, and project management issues encountered in clinical trials; and 6) foster a networking structure to build relationships with leading experts in substance use disorder clinical trials research. Scholars will participate in a 3-year training, consisting of a yearly 4-week summer intensive program of seminars and workshops at UCSF, mentoring and training during the academic year, and participation in CTN national research and training meetings. Scholars will be matched with NIDA CTN senior investigators who will mentor them through the 3-year training period. A successful NIH award for research or career development is the planned measurable outcome for the scholars who participate in the program. The program addresses the need for investigators who have expertise in conducting culturally-competent substance use disorder treatment research that has the potential to impact healthcare policy and practice. The long-term goal to increase the number of PIs from underrepresented racial/ethnic minority groups conducting substance use disorder treatment research.