Expanding Access to Buprenorphine Treatment among Homeless Persons with Opioid Use Disorder

扩大患有阿片类药物使用障碍的无家可归者获得丁丙诺啡治疗的机会

基本信息

项目摘要

ABSTRACT Opioid overdose is a major cause of death among people experiencing homelessness. Although buprenorphine treatment is effective for opioid use disorder (OUD), homeless persons experience multiple barriers to accessing this life-saving medication. Recently, the FDA approved a once-monthly injectable extended-release buprenorphine formulation for treatment of OUD, which may offer an alternative to sublingual buprenorphine for populations challenged by adherence, such as homeless persons. Long-acting formulations of buprenorphine treatment hold promise for improving adherence, retention, and clinical outcomes. However, little information exists about how amenable out-of-treatment homeless persons with OUD may be to an injectable buprenorphine formulation. Furthermore, although buprenorphine treatment can occur in a variety of settings, limited research has measured readiness of system models of care for the treatment of OUD among homeless persons. This project aims to assess individual, provider and system-level barriers and facilitators to accessing buprenorphine treatment among homeless people with OUD. Guided by the Consolidated Framework for Implementation Research, we will use an exploratory sequential mixed method design to identity potential individual, provider, and system-level barriers to implementation of buprenorphine treatment in two service settings: homeless shelters and syringe access programs. The specific aims of the project are: (1) assess organizational capacity and organizational readiness for the expansion of buprenorphine treatment in homeless shelters and syringe access programs; and (2) assess willingness of homeless people with OUD to receive buprenorphine treatment, preferences for different buprenorphine treatment formulations (sublingual vs. injection), and identify factors associated with preferences for buprenorphine treatment formulations. To achieve Aim 1, we will conduct in-depth interviews, focus groups, and surveys with health care providers, program staff, and program directors working at homeless shelters and syringe access programs. In Aim 2, we will recruit 200 homeless persons from homeless shelters, syringe access programs, and homeless encampments; and then administer structured surveys to identify preferences for buprenorphine treatment formulations, and identify predictors of preferences for different buprenorphine treatment formulations. Researchers can use the results of this study to inform the planning of buprenorphine treatment for out-of- treatment homeless persons with OUD, and we will use these results to conduct a subsequent feasibility and acceptability trial of sublingual buprenorphine vs. extended release buprenorphine to treat OUD in homeless persons.
摘要 阿片类药物过量是无家可归者死亡的主要原因。虽然 丁丙诺啡治疗对阿片类药物使用障碍(OUD)有效,无家可归者经历多种 这是获得这种救命药物的障碍。最近,FDA批准了每月一次的注射剂 用于治疗OUD的丁丙诺啡缓释制剂,其可提供舌下给药的替代方案 丁丙诺啡,用于受依从性挑战的人群,如无家可归者。长效制剂 丁丙诺啡治疗有望改善依从性,保留和临床结果。然而,在这方面, 很少有信息存在如何顺应治疗无家可归的人与OUD可能是一个 注射用丁丙诺啡制剂。此外,尽管丁丙诺啡治疗可以发生在各种不同的患者中, 设置,有限的研究已经衡量了准备系统模型的护理治疗OUD之间 无家可归的人。该项目旨在评估个人、提供者和系统层面的障碍和促进因素, 在无家可归的OUD患者中获得丁丙诺啡治疗。在综合指导下, 实施研究框架,我们将使用探索性顺序混合方法设计, 识别实施丁丙诺啡治疗的潜在个人、提供者和系统级障碍 在两个服务环境中:无家可归者收容所和注射器访问计划。该项目的具体目标是: (1)评估扩大丁丙诺啡治疗的组织能力和组织准备情况 在无家可归者收容所和注射器访问计划;和(2)评估与OUD无家可归者的意愿 接受丁丙诺啡治疗,对不同丁丙诺啡治疗制剂的偏好(舌下 vs.注射),并确定与偏好丁丙诺啡治疗制剂相关的因素。到 为了实现目标1,我们将与医疗保健提供者进行深入访谈、焦点小组和调查, 项目工作人员和在无家可归者收容所和注射器获取项目工作的项目主任。在目标2中, 将招募200名无家可归者从无家可归者收容所,注射器访问计划,和无家可归者 营地;然后进行结构化调查,以确定对丁丙诺啡治疗的偏好 本发明提供了一种新的丁丙诺啡治疗制剂,并确定不同丁丙诺啡治疗制剂的偏好的预测因子。 研究人员可以利用这项研究的结果来告知丁丙诺啡治疗计划, 治疗无家可归的人与OUD,我们将利用这些结果进行后续的可行性和 舌下丁丙诺啡与缓释丁丙诺啡治疗无家可归者OUD的可接受性试验 人士

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Cognitive impairment in individuals currently using methamphetamine.
  • DOI:
    10.1080/10550490050148053
  • 发表时间:
    2000-07
  • 期刊:
  • 影响因子:
    0
  • 作者:
    S. Simon;Catherine P. Domier;J. Carnell;Paul Brethen;R. Rawson;W. Ling
  • 通讯作者:
    S. Simon;Catherine P. Domier;J. Carnell;Paul Brethen;R. Rawson;W. Ling
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Carmen L Masson其他文献

Carmen L Masson的其他文献

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{{ truncateString('Carmen L Masson', 18)}}的其他基金

Digital Health Technology Use Among Methadone Maintenance Patients
美沙酮维持治疗患者中数字健康技术的使用
  • 批准号:
    9271370
  • 财政年份:
    2015
  • 资助金额:
    $ 20.29万
  • 项目类别:
Digital Health Technology Use Among Methadone Maintenance Patients
美沙酮维持治疗患者中数字健康技术的使用
  • 批准号:
    8893764
  • 财政年份:
    2015
  • 资助金额:
    $ 20.29万
  • 项目类别:
Mentoring Early-Career Scientists for Drug Abuse Research Careers
指导早期职业科学家的药物滥用研究职业
  • 批准号:
    8662927
  • 财政年份:
    2014
  • 资助金额:
    $ 20.29万
  • 项目类别:
Mentoring Emerging Scientists for Careers in Substance Use Research
指导新兴科学家从事药物使用研究的职业
  • 批准号:
    10623172
  • 财政年份:
    2014
  • 资助金额:
    $ 20.29万
  • 项目类别:
Mentoring Early-Career Scientists for Drug Abuse Research Careers
指导早期职业科学家的药物滥用研究职业
  • 批准号:
    9480125
  • 财政年份:
    2014
  • 资助金额:
    $ 20.29万
  • 项目类别:
Mentoring Emerging Scientists for Careers in Substance Use Research
指导新兴科学家从事药物使用研究的职业
  • 批准号:
    9920115
  • 财政年份:
    2014
  • 资助金额:
    $ 20.29万
  • 项目类别:
Mentoring Emerging Scientists for Careers in Substance Use Research
指导新兴科学家从事药物使用研究的职业
  • 批准号:
    10166811
  • 财政年份:
    2014
  • 资助金额:
    $ 20.29万
  • 项目类别:
Mentoring Emerging Scientists for Careers in Substance Use Research
指导新兴科学家从事药物使用研究的职业
  • 批准号:
    9533033
  • 财政年份:
    2014
  • 资助金额:
    $ 20.29万
  • 项目类别:
Mentoring Emerging Scientists for Careers in Substance Use Research
指导新兴科学家从事药物使用研究的职业
  • 批准号:
    10386889
  • 财政年份:
    2014
  • 资助金额:
    $ 20.29万
  • 项目类别:
Hepatitis Care Coordination in Methadone Treatment
美沙酮治疗中的肝炎护理协调
  • 批准号:
    7434521
  • 财政年份:
    2006
  • 资助金额:
    $ 20.29万
  • 项目类别:

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