Interdisciplinary Training in Pathobiology and Rehabilitation Medicine.

病理学和康复医学跨学科培训。

• 批准号: 10623981
• 负责人: Thomas W Buford
• 金额: $ 40.28万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-04 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10623981
• 关键词: Physical Medicine; Training

PROJECT SUMMARY The overarching goal of the mixed predoctoral and postdoctoral T32HD071866 training program is to develop burgeoning scientists into future leaders in translational rehabilitation research – scientists who are equipped to test and disseminate novel rehabilitative strategies that will alleviate impairment and compromised life quality in the face of chronic disease management. To meet this goal, we will build on achievements during the first two funding cycles, as the program grew in number of trainees and established a reputation that attracts high caliber applicants nationwide. The now proven program leverages an exceptionally rich institutional environment that offers myriad resources, and a collaborative team of mentors who are deeply committed to training and career development. Trainees benefit from two years of interdisciplinary training that carefully meld three core levels of scientific inquiry: : (i) cellular, molecular, and computational pathobiology; (ii) rehabilitation science/physiology; and (iii) epidemiology, clinical trials, and outcomes research. Based upon the strength of expertise in our mentors, translational rehabilitation research training in the renewal period three areas of concentrated strength: 1) Musculoskeletal Disorders, (2) Neurologic Diseases, and 3) Cardiopulmonary Diseases. Predoctoral trainees are selected from a highly competitive and diverse national pool admitted to a UAB graduate program (e.g., Graduate Biomedical Sciences, Rehabilitation Science). Nationally recruited postdoctoral trainees leverage institutionally funded training/career development programs tailored to meet diverse postdoctoral training goals. Each trainee’s primary mentor and Translational Mentoring Team are drawn from expert program faculty across multiple UAB Colleges and Schools. Together the trainee, mentor, and Translational Mentoring Team craft an individual development plan, approved and monitored semi-annually by the Executive Committee. The plan includes coursework, laboratory and clinical research, professional development programs, workshops, presentations locally and at national meetings, and training in the responsible conduct of research. Learning to conduct and publish high-impact research is a primary focus. The program will continue mentoring 3 predoctoral and 4 postdoctoral trainees each year, and will leverage expansive resources to continue to maximize recruitment and training of underrepresented minorities and individuals with disabilities. As a top 25 NIH-funded academic medical center with over 80 state-of-the-art scientific core facilities and a connected network of University-wide, interdisciplinary research centers; the University of Alabama at Birmingham is remarkably well-positioned to cultivate truly translational scientists equipped to drive the field of rehabilitation medicine with cutting edge research.

项目摘要 混合的博士前和博士后T32 HD 071866培训计划的总体目标是开发 新兴的科学家转化为未来的领导者康复研究-科学家谁是装备， 测试和传播新的康复策略，以减轻损伤和降低生活质量 面对慢性病的管理。为实现这一目标，我们将在第一个 两个资金周期，随着该计划的受训人数增加，并建立了吸引高 全国范围内优秀的申请者现在经过验证的计划利用了一个非常丰富的机构 环境，提供了无数的资源，和一个协作团队的导师谁是深深致力于 培训和职业发展。学员受益于两年的跨学科培训， 融合科学探究的三个核心层次：（i）细胞、分子和计算病理生物学;（ii） 康复科学/生理学;以及（iii）流行病学、临床试验和结果研究。基于 在我们的导师专业力量，翻译康复研究培训在更新期三 力量集中的领域：1）肌肉骨骼疾病，（2）神经系统疾病，和3） 心脏病博士前学员是从一个高度竞争和多元化的国家挑选出来的。 被UAB研究生课程录取的学生（例如，研究生生物医学科学，康复科学）。 国家招募的博士后学员利用机构资助的培训/职业发展计划 以满足不同的博士后培养目标。每位学员的主要导师和翻译导师 团队来自多个UAB学院和学校的专家课程教师。在一起的实习生， 导师和翻译指导团队制定个人发展计划，并予以批准和监督 执行委员会每半年进行一次。该计划包括课程，实验室和临床研究， 专业发展计划，研讨会，在当地和国家会议上的演讲，以及 负责任地进行研究。学习进行和发表高影响力的研究是一个主要的重点。 该计划将继续每年指导3名博士前和4名博士后学员，并将利用 扩大资源，继续最大限度地招聘和培训代表性不足的少数群体， 残疾人。作为NIH资助的前25名学术医疗中心，拥有80多个最先进的 科学的核心设施和大学范围内的跨学科研究中心的连接网络; 伯明翰的亚拉巴马大学在培养真正的翻译科学家方面处于非常有利的地位 配备先进的设备，推动康复医学领域的前沿研究。

项目成果

Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test.

• DOI: 10.1111/gbb.12300
• 发表时间: 2016-07
• 期刊: Genes, brain, and behavior
• 作者: Arrant AE;Filiano AJ;Warmus BA;Hall AM;Roberson ED
• 通讯作者: Roberson ED

Systematic Review on Exercise Training as a Neuroplasticity-Inducing Behavior in Multiple Sclerosis.

• DOI: 10.1177/1545968320921836
• 发表时间: 2020-07
• 期刊: Neurorehabilitation and neural repair
• 影响因子: 4.2
• 作者: Sandroff BM;Jones CD;Baird JF;Motl RW
• 通讯作者: Motl RW

A long-term ketogenic diet in young and aged rats has dissociable effects on prelimbic cortex and CA3 ensemble activity.

• DOI: 10.3389/fnagi.2023.1274624
• 发表时间: 2023
• 期刊: Frontiers in aging neuroscience
• 影响因子: 4.8

An Intervention to Improve Physical Function and Caregiver Perceptions in Family Caregivers of Persons With Heart Failure.

• DOI: 10.1177/0733464817746757
• 发表时间: 2020-02
• 期刊: Journal of applied gerontology : the official journal of the Southern Gerontological Society
• 作者: Gary R;Dunbar SB;Higgins M;Butts B;Corwin E;Hepburn K;Butler J;Miller AH
• 通讯作者: Miller AH

High-Intensity Exercise Acutely Increases Substantia Nigra and Prefrontal Brain Activity in Parkinson's Disease.

• DOI: 10.12659/msm.906179
• 发表时间: 2017-12-23
• 期刊: Medical science monitor : international medical journal of experimental and clinical research
• 作者: Kelly NA;Wood KH;Allendorfer JB;Ford MP;Bickel CS;Marstrander J;Amara AW;Anthony T;Bamman MM;Skidmore FM
• 通讯作者: Skidmore FM