The Exercise and Physical Activity Collaborative Team (ExPACT): A MoTrPAC Clinical Center

项目摘要 物理活动联盟的分子传感器（MoTrPAC）旨在发现和表征 运动对人体影响的分子转换器的范围。MoTrPAC于2004年启动， 2016年与六个成人临床中心和一个儿科中心合作， 指导涉及临床操作所有方面的研究方案（第一阶段）。二期 从2019年秋季开始，所有人类临床中心在初始招募方面都取得了出色的进展 议定书的目标和执行情况。NIH设定的最初目标是招募270名儿童（10-17岁 1980名久坐不动的成年人（18岁或以上），随机接受耐力训练 (170青年，840名成人），阻力训练（840名成人），或非运动对照（50名青年，300名成人）。一个 另一组高强度耐力训练组（50名青年，150名成人）和阻力训练组（150名成人） 作为比较者，不参加MoTrPAC运动训练计划。招募和 招生方法是性别平衡的，参与者年龄范围很广（10-17岁，18-39岁，40-59岁 60岁以上的年龄组）和不同的种族。由于COVID-19大流行，MoTrPAC活动 暂停一年多（从2020年3月开始），并将持续到2022年。尽管 由于大流行病、成人和儿科的招募活动， 临床中心已加速到预计成功实现目标入组数的速度 在新的奖励期结束之前。这导致NIH共同基金发布了目前的NOFO（RFA-RM- 23-010）为MoTrPAC提供资金，以完成临床研究的招募和随访，包括 完成对久坐的成人和儿童的机械随机对照试验以及对 高度活跃的成人和儿童。这将丰富参与者群体，这对理解运动至关重要 不同年龄、性别和少数群体的适应性和异质性。总的来说，这一扩展将允许 MoTrPAC将完成最初设想的预期目标，并将提供更完整的公共 数据库的健康益处的锻炼，并提供洞察如何身体活动减轻疾病。

PROJECT SUMMARY The Molecular Transducers of Physical Activity Consortium (MoTrPAC) is designed to discover and characterize the range of molecular transducers that underlie the effects of exercise in humans. MoTrPAC was launched in 2016 with six adult clinical centers and a pediatric center that have collaborated to generate extensive Manual of Operations to guide research protocols involving all aspects of the clinical operations (Phase I). Phase II began in the fall of 2019 with all human clinical centers showing excellent progress towards initial recruitment goals and implementation of the protocol. The initial goal set forth by NIH was to recruit 270 children (10-17 years of age) and 1980 sedentary adults (age 18 years or greater) that are randomized to endurance training (170 youth, 840 adults), resistance training (840 adults), or non-exercise controls (50 youth, 300 adults). An additional group of highly active endurance (50 youth, 150 adults) and resistance (150 adults) trained individuals serve as comparators and are not participating in the MoTrPAC exercise training programs. The recruitment and enrollment approach are sex balanced and with participants across a wide range of ages (10-17, 18-39, 40-59 and >60-year age groups) and of different races. Due to the COVID-19 pandemic, MoTrPAC activities were suspended for over a year (beginning in March 2020) with continued constraints through 2022. Despite the numerous challenges encountered as a result of the pandemic, recruitment activities at the adult and pediatric clinical centers have accelerated to a rate that is projected to successfully achieve the target enrollment numbers by the end of the new award period. This led to the NIH Common Fund to release the current NOFO (RFA-RM- 23-010) to provide MoTrPAC with funding to complete recruitment and follow-up for the clinical studies, including finishing mechanistic randomized controlled trials of sedentary adults and children and observational studies of highly active adults and children. This will enrich the participant cohorts that are critical to understand exercise adaptations and heterogeneity across age, gender, and minority groups. Altogether, this extension will allow MoTrPAC to complete the intended goals as originally envisioned and will provide a more complete public database of the health benefits of exercise and provide insight into how physical activity mitigates disease.