Translational Training in Addiction

成瘾转化培训

• 批准号: 10624227
• 负责人: Melissa Jean Zielinski
• 金额: $ 47.03万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10624227
• 关键词: Training; addiction

PROJECT SUMMARY/ABSTRACT This proposal seeks competitive renewal (years 11-15) of the UAMS NIDA T32 training program “Translational Training in Addiction”. Spanning five academic departments and three Colleges, the program provides multi- level, cross-disciplinary, team science training that spans the full translational research gamut from molecular to population-based approaches to solutions to curb or halt drug addiction. With program priorities of training innovation, diversity, connectivity and outcomes, this renewal request seeks to further the development of a program of training excellence that is dynamic and evolving in response to the rapidly changing societal, legislative, research, clinical and community responses to addiction. Quantitative and qualitative data support the claim of program excellence for the current funding cycle. A program evaluation plan is based on progress towards seven training objectives including (1) foster a shared knowledge of the broad societal and health impacts of drug use disorders and of the diversity of engaged scientific disciplines, (2) provide an individualized path to diverse addiction impact career areas and maximize post-training outcomes, (3) foster diversity as a strength for maximizing program impact, (4) provide career building environments emphasizing interdisciplinary, team science, translational research, (5) innovate advances in training approaches to research ethics, professional development, and program connectivity, (6) evaluate both bibliometric and translational science benefit outcomes of the program, and (7) foster the engagement of physicians and other clinicians in the career building processes of the program. Program administration, connectivity and oversight would remain the roles of the program Director, co-Associate Directors, Governance and Steering Committees, and external evaluators/advisers. Continued support is requested for three levels of trainees involving three predoctoral students, four postdoctoral fellows, and four annual M2 summer addiction research interns, complemented by institutional support of one annual PGY3 psychiatry resident, to foster the addiction translational science training objective of the program. Program-wide courses, faculty-facilitated seminar and presentation series, professional development lectures and workshops, and elective mentored research training emphasis/impact areas would support translational research training opportunities across the full spectrum of T0 to T4 translational science. Mechanisms of trainee and program evaluation focus on both scientific bibliometric and translational human health and society benefit indicators of program impact. Significant institutional commitment and resources support the accrued value and continued success of the training program. A continued trainee-led program of community outreach would support a program goal of bringing addiction science and impact into the community. The UAMS T32 training program has established a cross-discipline network of connectivity between addiction researchers and clinicians that were previously unlinked to contribute to the building of a translational science workforce.

项目总结/摘要 本提案旨在竞争性更新（年11-15）UAMS NIDA T32培训计划“翻译 成瘾训练”。跨越五个学术部门和三个学院，该计划提供了多- 水平、跨学科、团队科学培训，涵盖从分子到整个转化研究领域 以人口为基础的方法来解决遏制或制止吸毒成瘾的问题。与培训计划的优先事项 创新，多样性，连通性和成果，这一更新请求旨在进一步发展一个 卓越的培训计划，是动态的，不断发展，以应对迅速变化的社会， 立法、研究、临床和社区对成瘾的反应。定量和定性数据支持 在当前的资助周期中，该项目的卓越表现。一个项目评估计划是以进度为基础的 实现七个培训目标，包括（1）促进广泛的社会和健康知识的共享 药物使用障碍的影响和参与科学学科的多样性，（2）提供个性化的 不同成瘾影响职业领域的途径，并最大限度地提高培训后的成果，（3）促进多样性， 最大化计划影响的力量，（4）提供职业建设环境，强调 跨学科，团队科学，转化研究，（5）创新培训方法的进步， 研究伦理，专业发展和程序连接，（6）评估文献计量学和 转化科学有利于该计划的成果，（7）促进医生和其他 临床医生在该计划的职业建设过程中。计划管理、连通性和监督 将继续担任项目主任、联席主任、治理和指导委员会的职务， 和外部评估员/顾问。要求继续支持三级受训人员， 博士前学生，四名博士后研究员，和四名年度M2夏季成瘾研究实习生， 辅以每年一名PGY 3精神病学住院医师的机构支持，以促进成瘾 该计划的翻译科学培训目标。课程范围内的课程，教师促进研讨会和 演示系列，专业发展讲座和研讨会，以及选修辅导研究 培训重点/影响领域将全面支持转化研究培训机会 T0到T4转化科学的光谱。培训生和方案评估机制侧重于这两个方面 科学的文献计量和翻译人类健康和社会效益指标的计划影响。 重大的机构承诺和资源支持了联合国系统的累积价值和持续成功。 培训计划。一个持续的由受训者领导的社区外展计划将支持以下计划目标： 将成瘾科学和影响力带入社区。UAMS T32培训计划建立了一个 成瘾研究人员和临床医生之间的跨学科连接网络， 与此无关，有助于建立一个转化科学的劳动力。

项目成果

Toward the Study of Trans-Disease Processes: A Novel Approach With Special Reference to the Study of Co-morbidity.

• DOI: 10.1080/15504260902869147
• 发表时间: 2009-04-01
• 期刊: Journal of dual diagnosis
• 影响因子: 2.2
• 作者: Bickel WK;Mueller ET
• 通讯作者: Mueller ET

Association between discontinuing chronic opioid therapy and newly diagnosed substance use disorders, accidents, self-inflicted injuries and drug overdoses within the prescribers' health care system: a retrospective cohort study.

• DOI: 10.1111/add.15689
• 发表时间: 2022-04
• 期刊: Addiction (Abingdon, England)
• 作者: Hayes CJ;Krebs EE;Li C;Brown J;Hudson T;Martin BC
• 通讯作者: Martin BC

Characteristics of Initial Prescription Episodes and Likelihood of Long-Term Opioid Use - United States, 2006-2015.

• DOI: 10.15585/mmwr.mm6610a1
• 发表时间: 2017-03-17
• 期刊: MMWR. Morbidity and mortality weekly report
• 作者: Shah A;Hayes CJ;Martin BC
• 通讯作者: Martin BC

Discrimination, psychological functioning, and substance use among U.S. young adults aged 18-28, 2017.

• DOI: 10.1037/pha0000502
• 发表时间: 2022-12
• 期刊: EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
• 影响因子: 2.3
• 作者: Jones, Dina M.;Masyn, Katherine E.;Spears, Claire Adams
• 通讯作者: Spears, Claire Adams

Combining Active Immunization with Monoclonal Antibody Therapy To Facilitate Early Initiation of a Long-Acting Anti-Methamphetamine Antibody Response.

• DOI: 10.1021/acs.jmedchem.5b00220
• 发表时间: 2015-06-11
• 期刊: Journal of medicinal chemistry
• 影响因子: 7.3
• 作者: Hambuchen MD;Carroll FI;Rüedi-Bettschen D;Hendrickson HP;Hennings LJ;Blough BE;Brieaddy LE;Pidaparthi RR;Owens SM
• 通讯作者: Owens SM