The Robert T. Malison Yale-Chulalongkorn Stress, Alcohol Use and Psychopathology Training Program

摘要 精神疾病是一系列慢性非传染性疾病，是一个全球性公共卫生问题 给国际社会带来巨大的经济、社会和医疗成本。压力，酒精使用和其他 各种因素（社会和环境;身体疾病）往往会加剧精神疾病。中低 收入和发展中国家受到的影响尤其严重， 专门用于了解、治疗和预防艾滋病毒/艾滋病的体制基础设施不够完善， 精神病理学我们提出了一个多学科的合作研究培训计划， 年朱拉隆功大学医学院之间的压力、酒精使用和精神病理学研究 泰国曼谷（泰国的主要研究中心）Phramongkutklao（PMK）医院，也在曼谷，以及宋卡王子 泰国合艾大学（PSU）和美国耶鲁大学医学院的合作。 由泰国和美国的领导人，朱拉隆功的Kalayasiri博士和朱拉隆功的波滕扎博士和Gelernter博士指导， 耶鲁大学，这个应用程序的mpi。为泰国受训人员提出了三个主要培训机制，包括长期- 定期（1-2年）博士前和博士后研究金，以及短期（1-6个月）研究金。在五- 一年计划，朱拉隆功，PMK和PSU的培训责任增加（随着经验的积累）， 在耶鲁大学的下降。这个项目建立在耶鲁大学精神病学的广泛研究项目之上 以及耶鲁大学研究人员和研究人员之间现有的培训和研究合作 在朱拉隆功，研究精神病理学的遗传学和临床相关性（特别是物质 使用障碍）。该方案将有助于提高朱拉隆功的调查人员的能力， PMK和PSU以及更普遍的泰国在跨学科和跨文化领域进行最先进的研究， 通过一系列培训经验（遗传学，分子生物学，临床， 发展、精神药理学、临床试验、神经影像学、实施、社区和政策 研究）;并具有强大的临床翻译潜力。该计划明确的长期目标将 是建立一个科学家，卫生专业人员和学者的专业知识和可持续发展的临界质量 泰国合作机构的研究环境，以更好地了解，治疗和预防非传染性疾病， 精神疾病。这项培训计划也是专门为一个主要的公共卫生目的而设计的 通过加强泰国应对主要健康问题的能力，包括酒精和其他与压力有关的问题， 泰国历史上前所未有的混乱该计划的背景是一项长期的研究， 耶鲁大学和朱拉隆功大学之间的培训合作，重点是药物依赖， 在耶鲁大学的研究这一新方案有一个新的重点，扩大了范围，以解决 更好地满足泰国的需求，包括泰国mPI，现在被命名为“罗伯特T。Malison Yale-Chulalongkorn 压力，酒精使用和精神病理学培训计划“博士Malison，谁在2020年7月通过。

Abstract Psychiatric disorders are a set of chronic, non-communicable diseases (NCDs), a global public health problem of enormous economic, social, and medical cost to the international community. Stress, alcohol use and other factors (social and environmental; physical disorders) often exacerbate psychiatric disorders. Low and middle income and developing countries are disproportionately affected due to both economic disadvantages and the less well-established institutional infrastructures dedicated to the understanding, treatment and prevention of psychopathology. We propose a collaborative research training program in the multidisciplinary, translational research of stress, alcohol use and psychopathology between Faculty of Medicine, Chulalongkorn University in Bangkok, Thailand (the lead Thai site) Phramongkutklao (PMK) Hospital, also in Bangkok, and Prince of Songkla University (PSU) in Hat Yai, Thailand; and the Yale University School of Medicine in the U.S. The project is directed by leaders in Thailand and the US, Dr. Kalayasiri at Chulalongkorn, and Drs. Potenza and Gelernter at Yale, mPIs for this application. Three major training mechanisms are proposed for Thai trainees, including long- term (1-2-yr) predoctoral and postdoctoral fellowships, and short-term (1-6 month) fellowships. During the five- year program, training responsibility increases at Chulalongkorn, PMK, and PSU (as experience builds) and decreases at Yale. This program builds on an extensive research program in Psychiatry at Yale University School of Medicine, and on existing training and research collaborations between investigators at Yale and investigators at Chulalongkorn in the study of the genetics and clinical correlates of psychopathology (especially substance use disorders) in Thai populations. The program will contribute to the capacity of investigators at Chulalongkorn, PMK and PSU and more generally in Thailand to conduct state-of-the-art research in interdisciplinary and translational research in psychiatry through a range of training experiences (genetics, molecular biology, clinical, developmental, psychopharmacology, clinical trials, neuroimaging, implementation, community, and policy research); and has strong ongoing potential for clinical translation. The explicit long-term goal of the program will be to build a critical mass of scientists, health professionals, and academics with expertise and a sustainable research environment at the collaborating Thai institutions to better understand, treat, and prevent the NCDs of psychiatric illnesses. This training program is also specifically designed to serve a major public health purpose by enhancing Thailand’s capacity to confront major health concerns including alcohol and other stress-related disorders that are unprecedented in Thailand’s history. The context of this program is a long-term research and training collaboration between Yale and Chulalongkorn that focused on drug dependence which was co-led by at Yale by Drs. Gelernter and Malison. This new program with a new focus is expanded in scope to address the needs of Thailand better and include a Thai mPI, and is now named “The Robert T. Malison Yale-Chulalongkorn Stress, Alcohol Use and Psychopathology Training Program” for Dr. Malison, who passed in July, 2020.