Retention and Re-Engagement in Treatment for Addiction following Serious Injection Related Infections (RETAIN)
严重注射相关感染后保留和重新参与成瘾治疗(RETAIN)
基本信息
- 批准号:10624813
- 负责人:
- 金额:$ 18.94万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-06-15 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:Acute suppurative arthritis due to bacteriaAddressAdvisory CommitteesAntibioticsAreaBacteremiaBiometryBoard CertificationBostonBuprenorphineCaringCessation of lifeClinical TrialsClinical Trials DesignCommunicable DiseasesComplexContinuity of Patient CareDataData SetDevelopmentDrug usageEndocarditisEnrollmentEpidural AbscessEventEvidence based interventionFutureGoalsHealth care facilityHealthcare SystemsHomeHospitalizationHospitalsImprisonmentIndividualInfectionInfective endocarditisInjectableInjectionsInpatientsInterventionInterviewIntravenousK-Series Research Career ProgramsLeadLinkMassachusettsMedicalMedical centerMedicineMentorshipMethadoneModelingMorbidity - disease rateNaltrexoneNational Institute of Drug AbuseOsteomyelitisOutcomeOutpatientsOverdoseParticipantPersonsPopulationPositioning AttributePrimary CarePublic HealthQualitative MethodsRandomized, Controlled TrialsRecordsRecoveryRecurrenceResearchResearch PersonnelSpecialistStructureTestingTrainingWorkacceptability and feasibilityacute careaddictioncareercheckup examinationcostdesigneffectiveness trialevidence baseexperiencehigh risk populationhospital carehospital readmissionimprovedinsightlarge datasetsmedication for opioid use disordermortalitymotivational enhancement therapynovelopioid epidemicopioid injectionopioid overdoseopioid useopioid use disorderoutreachpeerpreventprogramsrandomized trialresponseskillssubstance use treatmentsuccesstherapy developmenttrial design
项目摘要
PROJECT SUMMARY
Serious injection-related infections (SIRIs), including infective endocarditis, bacteremia, osteomyelitis, epidural
abscess, and septic arthritis have more than doubled since 2002 due to the opioid epidemic, causing morbidity,
mortality, and costing more than $700 million annually. Growing evidence suggests that medications for opioid
use disorder (MOUD) which include methadone, buprenorphine, and extended-release naltrexone reduce
readmission and death following SIRIs. In response to this emerging data, programs and studies seek to
optimize MOUD initiation in hospitals. However, the benefits of MOUD have not been fully realized due to
limited retention in treatment with MOUD after hospitalization. To date, there has been a paucity of research
focused on MOUD retention, the crucial next step of the opioid use disorder (OUD) care continuum. Further,
evidence-based MOUD retention interventions have not been adapted for individuals with SIRIs who have
riskier injection practices, greater medical complexity, mortality, and costs than others with OUD. The
Recovery Management Checkups model is a proactive, peer-delivered, motivational interviewing-based MOUD
retention intervention that increased retention by 50% in outpatient addition treatment and following
incarceration. It has been piloted in multiple settings, making it a promising intervention for individuals with
SIRIs who face unique challenges following their infections. Therefore, the central objective of this proposal is
to determine individual and group factors associated with MOUD treatment along the OUD care continuum in
the critical 12 month period after a SIRI and to use these insights to adapt and test Recovery Management
Checkups for this new population. This proposal includes three aims: 1) Examine MOUD treatment along the
OUD care continuum in the 12 months after SIRIs; 2) Informed by the findings from Aim 1, adapt the Recovery
Management Checkups MOUD retention model for individuals with SIRIs; 3) Conduct a pilot randomized
controlled trial of the adapted intervention to promote MOUD retention and re-engagement for individuals with
SIRIs. The findings from these Aims address a gap in current research and will inform care for individuals with
SIRIs, a priority area for the National Institute on Drug Abuse. Dr. Kimmel, an early-career investigator is the PI
and will use this Career Development Award to develop skills in modeling approaches to address recurrent
events (e.g. multiple treatment episodes) and group membership (e.g. latent classes) in treatment retention
data, qualitative methods, intervention adaptation and development, and clinical trials design. Developing
these skills will position him to lead impactful research that will improve the care and outcomes for very high-
risk individuals who use drugs. Dr. Kimmel will work closely with a mentorship and advisory team with
experience in addiction medicine, infectious diseases, biostatistics, qualitative methods, intervention adaptation
and development and clinical trials to accomplish his research and training Aims.
项目总结
项目成果
期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Ending Medical Complicity With Skilled-Nursing Facility Discrimination Against People With Opioid Use Disorder.
结束医疗共谋与熟练护理机构对阿片类药物使用障碍患者的歧视。
- DOI:10.7326/m22-3049
- 发表时间:2023
- 期刊:
- 影响因子:39.2
- 作者:Cohen,ShawnM;Joab,Rebekah;Bolles,KathrynM;Friedman,Sally;Kimmel,SimeonD
- 通讯作者:Kimmel,SimeonD
Characteristics associated with motivation to stop substance use and improve skin and needle hygiene among hospitalized patients who inject drugs.
- DOI:10.1080/08897077.2021.2007520
- 发表时间:2022
- 期刊:
- 影响因子:3.5
- 作者:Kimmel, Simeon D.;Phillips, Kristina T.;Anderson, Bradley J.;Stein, Michael D.
- 通讯作者:Stein, Michael D.
Effect of police action on low-barrier substance use disorder service utilization.
- DOI:10.1186/s12954-022-00668-8
- 发表时间:2022-07-29
- 期刊:
- 影响因子:4.4
- 作者:Weisenthal, Karrin;Kimmel, Simeon D.;Kehoe, Jessica;Larochelle, Marc R.;Walley, Alexander Y.;Taylor, Jessica L.
- 通讯作者:Taylor, Jessica L.
Perspectives on long-acting injectable HIV antiretroviral therapy at an alternative care site: a qualitative study of people with HIV experiencing substance use and/or housing instability.
- DOI:10.1186/s12954-023-00730-z
- 发表时间:2023-01-10
- 期刊:
- 影响因子:4.4
- 作者:Fletcher, Laura;Burrowes, Shana A. B.;Khan, Ghulam Karim;Sabin, Lora;Johnson, Samantha;Kimmel, Simeon D. D.;Ruiz-Mercado, Glorimar;Pierre, Cassandra;Drainoni, Mari-Lynn
- 通讯作者:Drainoni, Mari-Lynn
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Simeon Kimmel其他文献
Simeon Kimmel的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Simeon Kimmel', 18)}}的其他基金
Retention and Re-Engagement in Treatment for Addiction following Serious Injection Related Infections (RETAIN)
严重注射相关感染后保留和重新参与成瘾治疗(RETAIN)
- 批准号:
10282857 - 财政年份:2021
- 资助金额:
$ 18.94万 - 项目类别:
Retention and Re-Engagement in Treatment for Addiction following Serious Injection Related Infections (RETAIN)
严重注射相关感染后保留和重新参与成瘾治疗(RETAIN)
- 批准号:
10428651 - 财政年份:2021
- 资助金额:
$ 18.94万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 18.94万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 18.94万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 18.94万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 18.94万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 18.94万 - 项目类别:
Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 18.94万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 18.94万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 18.94万 - 项目类别:
EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 18.94万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 18.94万 - 项目类别:
Research Grant