权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

A family-based intervention to improve HIV pre-exposure prophylaxis uptake for adolescent sexual minority males

以家庭为基础的干预措施，以提高性少数青少年男性对艾滋病毒暴露前预防的接受率

基本信息

批准号：
10624791
负责人：
Jack Rusley
金额：
$ 16.79万
依托单位：
RHODE ISLAND HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10624791
关键词：
AIDS prevention Address Adolescence Adolescent Adolescent Medicine Adolescent and Young Adult Adult Age Area Behavior Behavior Therapy Behavioral Sciences Bisexual Child Childhood Clinical Research Communication Counseling Data Disclosure Disparity Education Effectiveness Effectiveness of Interventions Environment Ethical Issues Family Foundations Friends Fumarates Funding Gays Goals HIV HIV Infections HIV risk Hospitals Incidence Individual Interdisciplinary Study Intervention Intervention Trial Interview Knowledge Learning Module Mentored Patient-Oriented Research Career Development Award Mentors Methods Motivation Outcome Assessment Parents Participant Play Population Populations at Risk Prevention Prevention Research Prevention strategy Primary Care Process Public Health Randomized Research Research Personnel Rhode Island Risk Risk Behaviors Risk Reduction Role Sampling Scientist Sexual Health Sexuality Source Tenofovir Testing Time Training Trust United States United States National Institutes of Health Universities Work Youth acceptability and feasibility attentional control behavior change career critical developmental period emtricitabine evaluation/testing evidence base experience follow-up formative assessment group intervention health disparity high risk high risk population implementation design implementation science improved interest intervention effect intervention mapping male male health men men who have sex with men motivational enhancement therapy parental involvement pilot test pre-exposure prophylaxis prevent preventive intervention primary care clinician primary care provider primary care setting primary outcome randomized trial recruit risk perception secondary outcome sexual debut sexual minority male sexual minority youth skills success therapy development tool transmission process uptake young man

项目摘要

PROJECT SUMMARY/ABSTRACT Dr. Rusley is pursuing this K23 Mentored Patient-Oriented Research Career Development Award to facilitate his transition to an independent HIV prevention scientist. His career goal is to eliminate health disparities among adolescents and young adults at risk for HIV. He has a background in pediatric and adolescent medicine, clinical research, public health, and motivational interviewing (MI) that create a strong foundation for the proposed training and research plan. He has assembled a highly accomplished and diverse team of mentors with complementary expertise in adolescent sexual minority male (ASMM) health, HIV prevention including pre-exposure prophylaxis (PrEP), behavioral interventions, family-based interventions, implementation science, and ethical issues in adolescent sexuality research. These mentors, along with an excellent and highly-interdisciplinary research environment at Brown University and Rhode Island Hospital will facilitate his training and research plan, as well as his transition to an independent, NIH- funded researcher. Given the disproportionate burden of HIV borne by sexual minority males in the US—especially young men—and the fact that most of these men have their first sexual experience as adolescents, ASMM are a key population for HIV prevention interventions. However, there are very few evidence-based HIV prevention interventions for this group, in part due to complexities with parental involvement in research. Many experts have called for inclusion of parents in HIV prevention interventions for ASMM, given the key protective roles they can play in their children’s lives; yet there are no family-based HIV prevention interventions for ASMM in the US. PrEP is a highly effective HIV prevention tool that has recently been added to the existing HIV prevention toolkit with FDA approval for adolescents in 2018, yet uptake among ASMM has been low. The few studies that address this gap in PrEP uptake among ASMM suggest possible barriers may include: concerns about disclosure of sexuality to parents (“outing”), knowledge of and motivation to use PrEP, and lack of access to primary care clinicians who prescribe PrEP. Therefore, we will develop a family-based HIV prevention intervention for ASMM that can be used in primary care settings. First, we will conduct a formative evaluation using in-depth individual interviews with ASMM (n=12-15) and parents (n=12-15) to determine barriers and facilitators to the success of the planned intervention (Specific Aim (SA) 1). Second, we will adapt an existing evidenced-based, motivational interviewing (MI) intervention to include PrEP education and counseling, as well as a family-based component (a video-based education module about parental support, sexuality communication, and PrEP as HIV prevention). We will then pilot the intervention with ASMM-parent dyads (n=10) (SA2). Finally, we will conduct an exploratory randomized trial of the intervention with ASMM-parent dyads (n=100) to test its effect on PrEP uptake at baseline and 8-week follow up, and to determine feasibility and acceptability (SA3). Overall, the intervention will reach a difficult to access population, build protective parent relationships, and increase PrEP uptake among a key population at risk, thereby reducing new HIV infections. The proposed training and research plan will provide Dr. Rusley the experience and mentoring needed to expand his skills and become an independent and leading HIV prevention scientist.

项目总结/文摘