Exploring the Dynamic Structures of Nucleic Acids
探索核酸的动态结构
基本信息
- 批准号:10624754
- 负责人:
- 金额:$ 41.56万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-05-01 至 2027-04-30
- 项目状态:未结题
- 来源:
- 关键词:BiologicalBiologyCoupledDNADiseaseDrug TargetingElementsGene ExpressionGenesIonsLigandsMalignant NeoplasmsMeasurementModelingMolecular ConformationMotivationNucleic AcidsPharmaceutical PreparationsProteinsRNAResolutionRoleSignal TransductionStructureTechniquesTherapeutic AgentsTherapeutic InterventionVaccinesVariantcomputerized toolsflexibilityinsightmRNA Translationmolecular scalenew therapeutic targetnucleic acid structureprogramsprotein complextargeted agent
项目摘要
The increasing recognition of RNA’s importance provides strong motivation for understanding
how its dynamic structures contribute to biology at the molecular scale. Much of RNA’s versatility
is derived from its intrinsic conformational flexibility and capacity to interact with a broad range of
cellular partners. Assessment of RNA’s structures is challenged by the variations that supports
these multiple roles. This program supports the continued application of tightly coupled
experimental and computational tools to characterize ensembles of RNA structures. Recent
advances enhance the resolution or interpretation of solution-based measurements, revealing
subtle but important changes in rigid elements, like duplexes, or the full range of structures
assumed by highly flexible unpaired strands. This project now extends studies of RNA from
isolated motifs to biologically functional elements and aims to resolve their atomically detailed
workings. A distinct focus is on the structural variation of single-stranded motifs. The capture or
release of these highly flexible regions is a potent signal exploited in regulating the translation of
mRNAs into proteins, via interactions with ions, small ligands or RNA motifs such as duplexes or
loops in helix-junction-helix motifs. Because of their importance in controlling gene expression,
these motifs offer new targets for therapeutic intervention or strategies for stabilizing existing
RNA-based drugs or vaccines. Finally, this project will continue successful efforts to characterize
the interaction of flexible nucleic acid motifs with proteins, laying the groundwork for
understanding how large nucleic acid-protein complexes function.
对RNA重要性的日益认识为理解提供了强大的动力
项目成果
期刊论文数量(14)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Ribosomal Protein L11 Selectively Stabilizes a Tertiary Structure of the GTPase Center rRNA Domain.
核糖体蛋白 L11 选择性地稳定 GTP 酶中心 rRNA 结构域的三级结构。
- DOI:10.1016/j.jmb.2019.12.010
- 发表时间:2020
- 期刊:
- 影响因子:5.6
- 作者:Welty,Robb;Rau,Michael;Pabit,Suzette;Dunstan,MarkS;Conn,GraemeL;Pollack,Lois;Hall,KathleenB
- 通讯作者:Hall,KathleenB
Elucidating the role of microprocessor protein DGCR8 in bending RNA structures.
- DOI:10.1016/j.bpj.2020.10.038
- 发表时间:2020-11
- 期刊:
- 影响因子:3.4
- 作者:S. Pabit;Yen-Lin Chen;E. T. Usher;E. Cook;L. Pollack;S. Showalter
- 通讯作者:S. Pabit;Yen-Lin Chen;E. T. Usher;E. Cook;L. Pollack;S. Showalter
How the Conformations of an Internal Junction Contribute to Fold an RNA Domain.
内部连接的构象如何有助于折叠RNA结构域。
- DOI:10.1021/acs.jpcb.8b07262
- 发表时间:2018-12-13
- 期刊:
- 影响因子:0
- 作者:Chen YL;Sutton JL;Pollack L
- 通讯作者:Pollack L
Structural analyses of an RNA stability element interacting with poly(A).
与 Poly(A) 相互作用的 RNA 稳定性元件的结构分析。
- DOI:10.1073/pnas.2026656118
- 发表时间:2021
- 期刊:
- 影响因子:11.1
- 作者:Torabi,Seyed-Fakhreddin;Chen,Yen-Lin;Zhang,Kaiming;Wang,Jimin;DeGregorio,SuzanneJ;Vaidya,AnandT;Su,Zhaoming;Pabit,SuzetteA;Chiu,Wah;Pollack,Lois;Steitz,JoanA
- 通讯作者:Steitz,JoanA
The structural plasticity of nucleic acid duplexes revealed by WAXS and MD.
蜡和MD揭示的核酸双链体的结构可塑性。
- DOI:10.1126/sciadv.abf6106
- 发表时间:2021-04
- 期刊:
- 影响因子:13.6
- 作者:He W;Chen YL;Pollack L;Kirmizialtin S
- 通讯作者:Kirmizialtin S
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LOIS POLLACK的其他文献
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{{ truncateString('LOIS POLLACK', 18)}}的其他基金
Nucleic acid interactions with partners: ions and proteins
核酸与伙伴的相互作用:离子和蛋白质
- 批准号:
10215554 - 财政年份:2017
- 资助金额:
$ 41.56万 - 项目类别:
Nucleic acid interactions with partners: ions and proteins
核酸与伙伴的相互作用:离子和蛋白质
- 批准号:
9918420 - 财政年份:2017
- 资助金额:
$ 41.56万 - 项目类别:
New targets for antibiotics: self assembling ribonucleoprotein complexes
抗生素的新靶点:自组装核糖核蛋白复合物
- 批准号:
8118843 - 财政年份:2009
- 资助金额:
$ 41.56万 - 项目类别:
New targets for antibiotics: self assembling ribonucleoprotein complexes
抗生素的新靶点:自组装核糖核蛋白复合物
- 批准号:
8310270 - 财政年份:2009
- 资助金额:
$ 41.56万 - 项目类别:
New targets for antibiotics: self assembling ribonucleoprotein complexes
抗生素的新靶点:自组装核糖核蛋白复合物
- 批准号:
7914043 - 财政年份:2009
- 资助金额:
$ 41.56万 - 项目类别:
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