Immunological Memory to Covid-19

Covid-19 的免疫记忆

• 批准号: 10632659
• 负责人: Rafi Ahmed
• 金额: $ 210万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-19 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10632659
• 关键词: 2019-nCoV; Antibody Response; Blood specimen; CD8-Positive T-Lymphocytes; COVID-19; COVID-19 long hauler; COVID-19 patient; Cancer Center; Cellular Immunity; Characteristics; Collaborations; Communities; Consent; Development; Diagnosis; Disease; Enrollment; General Population; Hospitalization; Humoral Immunities; Immune response; Immunity; Immunologic Memory; Immunologic Monitoring; Immunologics; Immunotherapeutic agent; Individual; Infection; Long COVID; Mediating; Monitor; Participant; Pathogenicity; Patients; Post-Acute Sequelae of SARS-CoV-2 Infection; SARS coronavirus; SARS-CoV-2 immunity; SARS-CoV-2 infection; Symptoms; T cell response; United States; Universities; Vaccines; adaptive immune response; cohort; global health; insight; longitudinal analysis; member; pandemic coronavirus; pandemic disease

ABSTRACT The SARS-CoV-2 coronavirus pandemic has created the largest global health crisis in almost a century. It is essential to understand the immunological responses that mediate long-term protective immunity to SARS-CoV-21. To assess the durability of humoral and cellular immunity to SARS-CoV-2 in COVID-19 patients we have been collecting longitudinal blood samples from convalescent individuals over the past 18 months. To date we have consented and enrolled 461 individuals that were infected with SARS-CoV-2 into our ongoing study. This cohort includes underrepresented and underserved members of the community. It is important to note that the vast majority (>90%) of the patients in our cohort had mild to moderate disease. This more reflective of COVID-19 infection in the general population. Using this cohort, we are proposing to extend our studies for an additional year to provide an analysis of the magnitude and durability of the antibody response, and CD4 and CD8 T cell responses to SARS-CoV-2 over a three-year period. In addition, 147 patients (32%) in our cohort were diagnosed as COVID-19 “long-haulers” with post- acute sequelae of SARS-CoV-2 (PASC), with symptoms for up to 18 months after infection onset. We will continue to monitor symptoms of PASC for an additional year and determine what features of the adaptive immune response are associated with the development of PASC. This study is a productive ongoing collaboration between the Emory Vaccine Center (PI: Rafi Ahmed) and the Fred Hutchinson Cancer Center (PI: Julie McElrath). Our studies will provide insight into the duration of immunological memory in COVID- 19 convalescent patients, and determine the correlation between PASC and the adaptive immune response.

抽象的 SARS-CoV-2 冠状病毒大流行造成了近一个世纪以来最严重的全球健康危机。它 对于了解介导长期保护性免疫的免疫反应至关重要 SARS-CoV-21。评估 COVID-19 中针对 SARS-CoV-2 的体液和细胞免疫的持久性 过去我们一直在从康复者身上收集纵向血液样本 18个月。迄今为止，我们已同意并登记了 461 名 SARS-CoV-2 感染者 进入我们正在进行的研究。该群体包括代表性不足和服务不足的成员 社区。值得注意的是，我们队列中的绝大多数 (>90%) 患者患有轻度至 中度疾病。这更能反映普通人群中的 COVID-19 感染情况。使用这个队列， 我们建议将我们的研究再延长一年，以分析其规模和影响 三年内抗体反应以及 CD4 和 CD8 T 细胞对 SARS-CoV-2 反应的持久性 时期。此外，我们队列中的 147 名患者 (32%) 被诊断为 COVID-19“长途运输者” SARS-CoV-2 (PASC) 的急性后遗症，症状在感染后长达 18 个月。我们将 继续监测 PASC 的症状一年，并确定适应性的哪些特征 免疫反应与 PASC 的发展相关。这项研究是一项富有成效的持续研究 埃默里疫苗中心（PI：Rafi Ahmed）与 Fred Hutchinson 癌症中心之间的合作 （PI：朱莉·麦克埃尔拉斯）。我们的研究将深入了解新冠肺炎中免疫记忆的持续时间 19名恢复期患者，测定PASC与适应性免疫的相关性 回复。