Immunological Memory to Covid-19

Covid-19 的免疫记忆

• 批准号: 10632659
• 负责人: Rafi Ahmed
• 金额: $ 210万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-19 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10632659
• 关键词: 2019-nCoV; Antibody Response; Blood specimen; CD8-Positive T-Lymphocytes; COVID-19; COVID-19 long hauler; COVID-19 patient; Cancer Center; Cellular Immunity; Characteristics; Collaborations; Communities; Consent; Development; Diagnosis; Disease; Enrollment; General Population; Hospitalization; Humoral Immunities; Immune response; Immunity; Immunologic Memory; Immunologic Monitoring; Immunologics; Immunotherapeutic agent; Individual; Infection; Long COVID; Mediating; Monitor; Participant; Pathogenicity; Patients; Post-Acute Sequelae of SARS-CoV-2 Infection; SARS coronavirus; SARS-CoV-2 immunity; SARS-CoV-2 infection; Symptoms; T cell response; United States; Universities; Vaccines; adaptive immune response; cohort; global health; insight; longitudinal analysis; member; pandemic coronavirus; pandemic disease

ABSTRACT The SARS-CoV-2 coronavirus pandemic has created the largest global health crisis in almost a century. It is essential to understand the immunological responses that mediate long-term protective immunity to SARS-CoV-21. To assess the durability of humoral and cellular immunity to SARS-CoV-2 in COVID-19 patients we have been collecting longitudinal blood samples from convalescent individuals over the past 18 months. To date we have consented and enrolled 461 individuals that were infected with SARS-CoV-2 into our ongoing study. This cohort includes underrepresented and underserved members of the community. It is important to note that the vast majority (>90%) of the patients in our cohort had mild to moderate disease. This more reflective of COVID-19 infection in the general population. Using this cohort, we are proposing to extend our studies for an additional year to provide an analysis of the magnitude and durability of the antibody response, and CD4 and CD8 T cell responses to SARS-CoV-2 over a three-year period. In addition, 147 patients (32%) in our cohort were diagnosed as COVID-19 “long-haulers” with post- acute sequelae of SARS-CoV-2 (PASC), with symptoms for up to 18 months after infection onset. We will continue to monitor symptoms of PASC for an additional year and determine what features of the adaptive immune response are associated with the development of PASC. This study is a productive ongoing collaboration between the Emory Vaccine Center (PI: Rafi Ahmed) and the Fred Hutchinson Cancer Center (PI: Julie McElrath). Our studies will provide insight into the duration of immunological memory in COVID- 19 convalescent patients, and determine the correlation between PASC and the adaptive immune response.

摘要 SARS-CoV-2冠状病毒大流行造成了近一个世纪以来最大的全球卫生危机。它 对于理解介导长期保护性免疫的免疫反应是至关重要的。 SARS-CoV-21。新冠肺炎人群对SARS-CoV-2体液免疫和细胞免疫的持久性评价 病人我们过去一直在从康复者身上采集纵向血样 18个月。到目前为止，我们已经同意并招募了461名感染SARS-CoV-2的人。 加入我们正在进行的研究中。这一群体包括代表不足和服务不足的 社区。值得注意的是，我们队列中的绝大多数(&gt；90%)患者患有轻度到 中度疾病。这更多地反映了新冠肺炎在普通人群中的感染。使用这个队列， 我们建议将我们的研究再延长一年，以提供对震级和 SARS-CoV-2抗体应答、CD4和CD8 T细胞应答在三年内的持久性 句号。此外，在我们的队列中，147名(32%)患者被诊断为后遗症患者，他们被诊断为新冠肺炎“长征者”。 SARS-CoV-2(PASC)的急性后遗症，感染后症状长达18个月。我们会 继续监测PASC的症状一年，并确定自适应 免疫反应与PASC的发生发展密切相关。这项研究是一项富有成效的持续研究 埃默里疫苗中心(PI：Rafi Ahmed)与弗雷德·哈钦森癌症中心的合作 (PI：Julie McElrath)我们的研究将提供对COVID免疫记忆持续时间的洞察- 19例恢复期患者，并测定PASC与获得性免疫的相关性 回应。