Insomnia Treatment and Cardiometabolic Health in Older Adults with Posttraumatic Stress Disorder

患有创伤后应激障碍的老年人的失眠治疗和心脏代谢健康

• 批准号: 10630503
• 负责人: Monica R Kelly
• 金额: $ 5.31万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10630503
• 关键词: Address; Behavioral; Biological Markers; Cardiometabolic Disease; Circadian Rhythms; Clinical Investigator; Clinical Psychology; Clinical Sciences; Clinical Trials; Cognitive; Cognitive Therapy; Comorbid Insomnia; Data; Doctor of Philosophy; Education; Elderly; Environment; Evidence based intervention; Fellowship; Foundations; Funding; Geriatrics; Gerontology; Goals; Health; Individual; Institutes; Intervention; Knowledge; Licensure; Measures; Mental Health; Mentored Patient-Oriented Research Career Development Award; Mentors; Morbidity - disease rate; Outcome; Pilot Projects; Population; Post-Traumatic Stress Disorders; Professional Competence; Quality of life; Randomized Controlled Trials; Research; Research Personnel; Research Training; Residual state; Resources; Risk; Risk Factors; Sleep; Sleeplessness; Symptoms; Training; Translational Research; Veterans; Work; cardiometabolic risk; cardiometabolism; career development; clinical care; clinical center; cognitive benefits; disorder risk; effective therapy; evidence base; experience; follow-up; improved; individualized medicine; medical schools; modifiable risk; mortality; physical conditioning; professor; programs; skill acquisition; sleep health; trial design

Project Summary/Abstract Monica Kelly, PhD is an Adjunct Assistant Professor at the David Geffen School of Medicine at UCLA. She is fully committed to becoming an independently funded investigator specializing in the study and treatment of sleep, cardiometabolic health and posttraumatic stress disorder (PTSD) in older adults. Dr. Kelly is an ideal candidate for this field of research with over 10 years of sleep and PTSD research experience, advanced geriatrics fellowship training, and licensure in clinical psychology. This K23 award will provide foundational career development skills for achieving her long-term goal of understanding and improving mental and physical health outcomes for older adults with insomnia and PTSD. Data collected will provide the basis of a larger, randomized controlled trial designed to examine the most effective treatment sequencing for mental health and cardiometabolic disease risk outcomes among older adults with comorbid insomnia disorder and PTSD. Career Development and Training Plan: The proposed work will be carried out at the UCLA and take advantage of available resources within the VAGLAHS, providing a rich training environment and the ability to conduct the proposed research and training plans. Dr. Kelly's team of nationally renowned mentors include Drs. Jennifer Martin (primary mentor; behavioral sleep interventions expert; K24 awardee), Cathy Alessi (geriatric sleep and health expert), Peter Liu (cardiometabolic health and sleep expert; K24 awardee), and Thomas Neylan (PTSD and sleep expert). Available resources include UCLA's Clinical and Translational Science Institute (CTSI), Multicampus Program in Geriatric Medicine and Gerontology (MPGMG), and the Geriatric Research, Education and Clinical Center (GRECC). Her training plan features carefully curated didactic and experiential training aligning her research and training goals in 1) clinical trials, 2) cardiometabolic health, 3) circadian rhythms, and 4) career skills necessary to become an independent clinical investigator. Research Plan: The proposed pilot randomized controlled trial will address a gap in knowledge related to addressing modifiable risk factors for cardiometabolic disease through treating residual insomnia in the context of PTSD in older adults. This project utilizes evidence-based interventions and standard clinical care measures. The study will evaluate the benefits of 5 sessions of Cognitive Behavioral Therapy for Insomnia (CBT-I) versus control, following 12 sessions of Cognitive Processing Therapy (CPT) for PTSD in older Veterans, an expanding group of individuals at elevated risk for PTSD, insomnia and cardiometabolic disease morbidity and mortality. The aims of this project are to 1) Evaluate the added benefits of CBT-I versus control on sleep, PTSD, and cardiometabolic risk biomarkers; 2) Evaluate CBT-I versus control following CPT on cardiometabolic risk biomarkers and quality of life; and 3) Evaluate the durability of the sleep, cardiometabolic and quality of life benefits of CBT-I following CPT versus control following CPT at 6-month follow-up.

项目摘要/摘要 莫妮卡·凯利（Monica Kelly）博士是加州大学洛杉矶分校（UCLA）大卫·格芬（David Geffen）医学院的兼职助理教授。她是 完全致力于成为专门研究和治疗的独立资助的研究人员 老年人的睡眠，心脏代谢健康和创伤后应激障碍（PTSD）。凯利博士是理想的 超过10年的睡眠和PTSD研究经验的研究领域的候选人，高级 老年奖学金培训和临床心理学许可。该K23奖将提供基础 职业发展技巧，以实现她理解和改善心理和身体的长期目标 老年人失眠和PTSD的健康结果。收集的数据将提供更大的基础 随机对照试验旨在检查心理健康和最有效的治疗测序 患有合并症失眠症和PTSD的老年人的心脏代谢疾病可能会产生结局。 职业发展和培训计划：拟议的工作将在UCLA进行并采取 在Vaglah中提供可用资源的优势，提供丰富的培训环境和能力 执行拟议的研究和培训计划。凯利博士的全国知名导师团队包括 博士。詹妮弗·马丁（Jennifer Martin）（主要导师；行为睡眠干预专家； K24获奖者），凯茜·阿里西（Cathy Alessi） （老年睡眠和健康专家），彼得·刘（peti tomemotic健康与睡眠专家； K24获奖者）和 Thomas Neylan（PTSD和睡眠专家）。可用资源包括加州大学洛杉矶分校的临床和翻译 科学研究所（CTSI），老年医学和老年学的多门课程（MPGMG）和 老年研究，教育和临床中心（GRECC）。她的培训计划精心策划 在1）临床试验中的教学和体验训练对齐她的研究和培训目标，2）心脏代谢 健康，3）昼夜节律和4）成为独立临床研究者所必需的职业技能。 研究计划：拟议的飞行员随机对照试验将解决与 通过治疗残留失眠来解决心脏代谢疾病的可修改风险因素 老年人的PTSD。该项目利用基于证据的干预措施和标准临床护理 措施。该研究将评估5次认知行为疗法的益处 （CBT-I）与对照相比，在较旧的PTSD认知处理疗法（CPT）之后 退伍军人，一群不断扩大的个人，患有PTSD，失眠和心脏代谢疾病风险较高的个体 发病率和死亡率。该项目的目的是1）评估CBT-I与控制的额外好处 睡眠，PTSD和心脏代谢风险生物标志物； 2）评估CBT-I与控制CPT之后 心脏代谢风险生物标志物和生活质量； 3）评估睡眠，心脏代谢的耐用性 CPT与CPT后CPT的CPT在6个月的随访后与CPT后的CPT-I的生活质量好处。