Early Oropharyngeal cancer and screening in Gay and Bisexual Men

男同性恋和双性恋男性的早期口咽癌和筛查

• 批准号: 10627224
• 负责人: MICHAEL W ROSS
• 金额: $ 20万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10627224
• 关键词: Address; Adjuvant; Africa; Africa South of the Sahara; African; Anus; Area; Assessment tool; Attitude; Belief; Bisexual; Cancer Etiology; Cancer Intervention; Cellular Phone; Cervical Cancer Screening; Cessation of life; Cities; Cohort Studies; Data; Diagnosis; Disease Progression; Early Diagnosis; Educational Curriculum; Educational process of instructing; Effectiveness; Enrollment; Epidemic; Evaluation; Exhibits; Funding; Future; Gays; General Population; HIV/STD; HPV-High Risk; Health; High Prevalence; Homosexuality; Human Papilloma Virus Vaccination; Human Papilloma Virus-Related Malignant Neoplasm; Human Papillomavirus; Human papilloma virus infection; Human papillomavirus 16; Incidence; Individual; Infection; Institutional Review Boards; Instruction; Internet; Intervention; Knowledge; Lesion; Malignant - descriptor; Malignant Neoplasms; Malignant neoplasm of anus; Malignant neoplasm of cervix uteri; Mediating; Needs Assessment; Notification; Oral; Oropharyngeal; Parents; Participant; Persons; Pharyngeal structure; Population; Publications; Questionnaires; Research; Resolution; Risk; Schedule; Screening for cancer; Secondary Prevention; Seeds; Self Assessment; Series; Severities; Sexual Health; Site; Specialist; Stigmatization; Students; Surveys; Swab; Tanzania; Testing; Throat Cancer; Time; Training; United States National Institutes of Health; Vaccinated; Vaccination; Visit; Woman; Work; acceptability and feasibility; cancer risk; early screening; firewall; follow-up; health disparity; high risk; interest; low and middle-income countries; low income country; malignant oropharynx neoplasm; men; metropolitan; parent grant; prevent; recruit; response; screening; sexual minority men; vaccine acceptance

Abstract This application is being submitted in response to the Notice of Special Interest (NOSI) identified as “NOT-CA- 22-057”. High-risk HPV (hrHPV) is a major transmissible cause of cancers of the anus and oropharynx in sexual minority men (SMM). Prevalence of hrHPV in SMM in Tanzania, East Africa, a LMIC, is high and probably epidemic in its largest metropolitan area, Dar es Salaam. We propose to replicate our study to invite and train Tanzanian SMM to take “selfies” of the oropharynx at sufficiently high resolution to observe potential early lesions that may be malignant. These “selfies” are rated by an expert on oropharyngeal cancer for sufficient clarity to detect early lesions. A group of 100 SMM will be recruited by both Internet and RDS seeds to participate in the study, and also offered a full course of hrHPV vaccination. An initial questionnaire on knowledge, attitudes and sexual practices will be completed on Internet and participants trained at a local NGO to take oral “selfies” which are uploaded to a firewalled Internet site for an ENT specialist to assess clarity. After enrollment, two further visits will be scheduled at 2 and 6 months for vaccination shots, and to assess retention for a future cohort study. Data on knowledge, attitudes, sexual risk practices, acceptability and feasibility of screening for oropharyngeal cancer, and hrHPV vaccination, in this population and setting will be assessed.

摘要 本申请是为了响应被标识为“NOT-CA-”的特别利益通知（NOSI）而提交的。 22-057”。高危型HPV（hrHPV）是导致肛门癌和口咽癌的主要传染性原因， 性少数男性（SMM）在东非坦桑尼亚的SMM中，hrHPV的流行率很高， 可能在其最大的都会区达累斯萨拉姆流行。我们建议复制我们的研究， 并训练坦桑尼亚SMM以足够高的分辨率拍摄口咽部的“自拍”， 早期病变可能是恶性的。这些“自拍照”被一位口咽癌专家评为 足够的清晰度来检测早期病变。互联网和RDS种子将招募100名SMM 参与研究，并提供了一个完整的hrHPV疫苗接种过程。初步调查表， 知识、态度和性行为将在因特网上完成，参加者将在当地一个非政府组织接受培训 拍摄口腔“自拍”，然后上传到一个有防火墙的网站上，供耳鼻喉科专家评估清晰度。 入组后，将在2个月和6个月时安排两次进一步访视，以进行疫苗接种，并评估 保留用于未来的队列研究。关于知识、态度、性风险做法、可接受性和 在这一人群和环境中进行口咽癌筛查和hrHPV疫苗接种的可行性， 评估。

项目成果

Oral/oropharyngeal "selfies" in gay and bisexual men: a pilot study exploring oropharyngeal screening for HPV-related possible malignancies.

• DOI: 10.3389/fpubh.2023.1233274
• 发表时间: 2023
• 期刊: FRONTIERS IN PUBLIC HEALTH
• 影响因子: 5.2
• 作者: Ross, Michael W.;Bennis, Sarah L.;Nichols, C. Mark;Zoschke, I. Niles;Wilkerson, J. Michael;Rosser, B. R. Simon;Stull, Cyndee L.;Nyitray, Alan G.;Flash, Charlene;Khariwala, Samir S.
• 通讯作者: Khariwala, Samir S.

HPV-related oropharyngeal cancer early detection in gay and bisexual men is an "orphan" practice: A qualitative analysis among healthcare providers.

• DOI: 10.3389/fpubh.2023.1165107
• 发表时间: 2023
• 期刊: FRONTIERS IN PUBLIC HEALTH
• 影响因子: 5.2
• 作者: Zoschke, I. Niles;Bennis, Sarah L.;Wilkerson, J. Michael;Stull, Cynthia L.;Nyitray, Alan G.;Khariwala, Samir S.;Nichols, C. Mark;Rosser, B. R. Simon;Flash, Charlene;Ross, Michael W.
• 通讯作者: Ross, Michael W.

Screening for HPV-Related Oropharyngeal Cancer in Gay and Bisexual Men: Acceptability and Predicting Possible Use of "Oral Selfies" by Smartphone as a Secondary Prevention Approach.

男同性恋和双性恋男性中 HPV 相关口咽癌的筛查：智能手机“口腔自拍”作为二级预防方法的可接受性和预测可能的使用。

• DOI: 10.3390/venereology2040016
• 发表时间: 2023
• 期刊: Venereology (Basel, Switzerland)
• 作者: Ross,MichaelW;Bennis,SarahL;Zoschke,Niles;SimonRosser,BrianR;Stull,CyndeeL;Nyitray,AlanG;Khariwala,SamirS;Nichols,Mark;Flash,Charlene;Wilkerson,Michael
• 通讯作者: Wilkerson,Michael