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HPV Oropharyngeal cancer and screening in Gay and Bisexual Men

男同性恋和双性恋男性的 HPV 口咽癌和筛查

基本信息

批准号：
10421060
负责人：
MICHAEL W ROSS
金额：
$ 34.74万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10421060
关键词：
Address Age Alcohols Area Assessment tool Attitude Awareness Back Behavioral Belief Biological Bisexual Cancer Detection Cancer Etiology Cellular Phone Cities Client Clinical Data Data Collection Dental Dental Care Dental Hygienists Dentists Detection Diagnosis Early Diagnosis Early treatment Education Effectiveness Ensure Evaluation Federally Qualified Health Center Frequencies Funding Gays Guidelines HIV HIV Infections HPV oropharyngeal cancer Health Health Professional Heavy Drinking High Prevalence Human Papilloma Virus Vaccination Human Papillomavirus Human papilloma virus infection Human papillomavirus 16 Incidence Infection International Intervention Interview Knowledge Lesbian Gay Bisexual Transgender Low income Malignant Neoplasms Medical Mouth Abnormalities Nurses Oral Oral Examination Oral Sex Oral cavity Oropharyngeal Patients Persons Pharyngeal structure Physician Assistants Physicians Population Prevalence Prevention program Primary Prevention Private Practice Privatization Prognosis Protocols documentation Provider Public Health Research Respondent Risk Risk Behaviors Risk Factors Sampling Screening for cancer Secondary Prevention Self Assessment Self-Examination Site Smoking Specialist Surveys Survival Rate Symptoms Target Populations Telecommunications Telemedicine Texas Training United States National Institutes of Health Vaccinated Visit Visual acceptability and feasibility base cancer risk early screening ethnic diversity ethnic minority experience impression improved innovation male malignant mouth neoplasm malignant oropharynx neoplasm medical examination men men who have sex with men metropolitan nicotine use phase I trial programs racial and ethnic racial diversity recruit remote patient monitoring screening screening guidelines self testing sexual minority men sexual risk behavior socioeconomic diversity tumor uptake willingness

项目摘要

Abstract: Oropharyngeal cancer (OPCa) caused by Human Papilloma Virus infection has risen steadily in the past two decades. It is primarily associated with sexual risk behavior, specifically oral sex in MSM. Oral cancers associated with HPV, when detected early by oral examination by medical and dental practitioners, can be successfully diagnosed and treated, with significantly increased survival. To improve screening and detection, we propose a 3-part study. First, to interview medical and dental teams, both private and in a Federally Qualified Health Center, with large GBM client bases in two large US metropolitan areas, to understand the screening and reasons for screening for oropharyngeal cancers and guidelines used. Second, we will survey 1500 GBM in the US to determine knowledge and beliefs about OPCa, HPV vaccination knowledge and uptake, experiences with providers and screening, and willingness to engage in screening. Finally, given the potential visibility of OPCa tumors to oral visual examination, we will assess the feasibility of a remote patient monitoring telecommunications-based intervention. We will ask GBM to take oral “selfies” with a cell phone, of sufficient clarity in regard to standard oral landmarks, and to send these photos to a central site where assessment can be made by an OPCa specialist clinician. The interview and survey data, and the feasibility results will be used to inform increased screening guidelines and education for both GBM and the practitioners who treat them, and to develop programs for increased awareness and screening in GBM. The acceptability, feasibility and preliminary efficacy data will assess whether self-examination and oral “selfies” are realistic and have the necessary clarity to form the basis of a telemedicine- based screening campaign for those at risk of developing OPCa, and its rigorous evaluation.

摘要：由人类乳头瘤病毒感染引起的口咽癌（OPCa）在过去的二十年它主要与性风险行为有关，特别是在男男性接触者与HPV相关的口腔癌，当通过医学检查早期发现时，和牙科医生，可以成功地诊断和治疗，与显着增加生存为了提高筛查和检测，我们提出了一个3部分的研究。第一，面试医疗和牙科团队，包括私人和联邦合格的健康中心， GBM的客户群分布在美国两个大都市区，了解筛选和原因用于口咽癌筛查和使用的指南。第二，我们将调查1500名在美国的GBM，以确定有关OPCa，HPV疫苗接种知识的知识和信念和吸收，与提供者和筛查的经验，以及参与筛查的意愿。最后，鉴于OPCa肿瘤对口腔视力检查的潜在可见性，我们将评估远程患者监测的可行性，基于预防的干预。我们会要求 GBM采取口头“自拍”与手机，足够清晰的关于标准的口头地标，并将这些照片发送到一个中心网站，在那里可以进行评估， OPCa专科临床医生。访谈和调查数据以及可行性研究结果将被使用为GBM和从业者提供更多的筛查指南和教育，治疗他们，并制定计划，提高认识和筛查GBM。的可接受性、可行性和初步疗效数据将评估自我检查和口头“自拍”是现实的，并具有必要的清晰度，以形成远程医疗的基础- 为那些有发展OPCa风险的人开展基于筛查的运动，并对其进行严格的评估。