Racial/Ethnic Disparities in Ovarian Cancer Treatment and Survival: An Integrative Approach

卵巢癌治疗和生存的种族/民族差异：综合方法

• 批准号: 10627588
• 负责人: Elisa V Bandera
• 金额: $ 20万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627588
• 关键词: Address; Administrative Supplement; Age; Aging; Algorithms; Area; California; Cancer Etiology; Cancer Patient; Characteristics; Chronic Disease; Clinical; Clinical Treatment; Collaborations; Computerized Medical Record; Country; Cultural Backgrounds; Data; Data Sources; Databases; Death Certificates; Development; Diagnosis; Dietary Factors; Documentation; Enrollment; Ethnic Origin; Ethnic group; European; Evaluation; Funding; Future; Geography; Health; Health Disparities Research; Healthcare; Heterogeneity; Hispanic; Hispanic Populations; Incidence; Income; Insurance; Interdisciplinary Study; Interest Group; Knowledge; Latin America; Malignant Female Reproductive System Neoplasm; Malignant Neoplasms; Malignant neoplasm of ovary; Medical Record Linkage; Methodology; Mexican; Mexico; North America; Not Hispanic or Latino; Outcome; Parents; Pathogenesis; Pathology; Pathway interactions; Patient Self-Report; Patients; Pattern; Population; Population Heterogeneity; Questionnaires; Race; Recurrence; Reporting; Reproductive History; Research; Research Personnel; Resource-limited setting; Resources; Risk Factors; Subcategory; Subgroup; Time; Time trend; Underrepresented Populations; Validation; Woman; Women' s Health; Work; administrative database; cancer diagnosis; cancer health disparity; cancer heterogeneity; cancer risk; cancer survival; cancer therapy; clinical care; cohort; comparative; disability; experience; follow-up; improved; interest; lifestyle factors; low and middle-income countries; malignant breast neoplasm; mortality; multi-ethnic; neoplasm registry; parent grant; population based; racial and ethnic disparities; research study; response; success; teacher

Project Abstract: This application is being submitted in response to the Notice of Special Interest (NOSI) identified as “NOT-CA-22-057”. Ovarian cancer is the most lethal gynecologic cancer in women in North America, yet our understanding of ovarian cancer etiology, recurrence, and survival in Hispanic women living in Latin America is lacking and our understanding of these factors in US Hispanic women is very limited. To facilitate the evaluation of the unique pathogenesis of ovarian cancer among understudied global populations, we will confirm ovarian cancer cases via medical record linkage and through centralized pathology review to identify the distribution of histotypes in cases from the Mexican Teachers' Cohort (MTC) and compare them with the Hispanic cases from Kaiser Permanente Northern California (KPNC). We will also determine the availability of data on clinical characteristics, treatment patterns, and outcomes for ovarian cancer cases diagnosed in MTC that facilitate future comparative analyses across race and ethnicity subgroups in KPNC. The KPNC population includes US Hispanic cases as one understudied group of interest and this supplemental funding to increase global cancer disparities research will support the inclusion of and comparison with a complementary group of ovarian cancer cases diagnosed among women living in Mexico from the MTC. Specifically, we will leverage the existing resources available in the MTC, including case validation linkages and algorithms developed for breast cancer, and apply them to ovarian cancer, to develop the capacity to evaluate a subset of the parent R01 research aims in the MTC. Importantly the ability to compare histotype distributions and survival of Hispanic women living in California to women living in a culturally, geographically, and economically diverse 12-state region in Mexico will improve the generalizability of our study findings and provide important and relevant data on an understudied and underrepresented population subgroup. Given that self-reported Hispanic ethnicity represents a diverse group with varying traditions and cultural backgrounds, we will also evaluate all comparisons with KPNC cases among the subgroup with self-reported Mexican ethnicity. Strengths of the proposed study include the overlapping study years for the two cohorts (2000-2018 KPNC, 2006-2022 MTC) and centralized pathology review. Additionally, this supplement expands our multi-disciplinary research team to include additional researchers with expertise in complementary areas who are committed to understanding racial and ethnic disparities in ovarian cancer.

项目摘要：本申请是为了响应特别利益通知（NOSI）而提交的。 标识为“NOT-CA-22-057”。卵巢癌是北方妇女最致命的妇科癌症 然而，我们对生活在美国的西班牙裔妇女的卵巢癌病因、复发和生存率的了解， 拉丁美洲是缺乏和我们的了解这些因素在美国西班牙裔妇女是非常有限的。到 有助于在研究不足的全球人群中评估卵巢癌的独特发病机制， 我们会透过病历联网及中央病理检查， 确定墨西哥教师队列（MTC）病例的组织型分布，并比较 与来自北方加州的西班牙裔病例（KPNC）。我们还将确定 卵巢癌病例的临床特征、治疗模式和结局数据的可用性 在MTC中诊断，便于将来在KPNC中进行人种和种族亚组的比较分析。 KPNC人群包括美国西班牙裔病例作为一个未充分研究的关注组， 增加全球癌症差异研究的补充资金将支持纳入和 与墨西哥妇女中诊断的卵巢癌病例的互补组进行比较 从MTC。具体而言，我们将利用MTC中现有的资源，包括案例 为乳腺癌开发的验证链接和算法，并将其应用于卵巢癌，以开发 评估MTC中父R 01研究目标子集的能力。重要的是， 比较居住在加州的西班牙裔妇女与居住在 墨西哥12个州的文化、地理和经济多样性将提高可推广性 我们的研究结果，并提供重要的和相关的数据，研究不足，代表性不足 人口亚组。鉴于自我报告的西班牙裔代表了一个多样化的群体， 传统和文化背景，我们还将评估与KPNC案例的所有比较， 自我报告的墨西哥种族亚组。拟议研究的优势包括重叠研究 两个队列（2000-2018年KPNC，2006-2022年MTC）和集中病理学审查。此外，本发明还 这一补充扩大了我们的多学科研究团队，包括额外的研究人员与专业知识 致力于了解卵巢癌中的种族和民族差异。