Establishing a link between habits and punishment resistance

在习惯和惩罚抵抗之间建立联系

• 批准号: 10628728
• 负责人: RACHEL J SMITH
• 金额: $ 7.03万
• 依托单位: TEXAS A&M UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-15 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10628728
• 关键词: Affect; Animal Model; Animals; Behavior; Behavioral; Characteristics; Cholinergic Agents; Cocaine; Control Animal; Corpus striatum structure; Data; Data Set; Development; Dorsal; Drug usage; Failure; Female; Financial compensation; Food; Functional disorder; GABA Agonists; Goals; Habits; Individual; Interneurons; Lead; Lesion; Link; Mediating; Microinjections; Outcome; Pathway interactions; Pattern; Pharmacology; Play; Prefrontal Cortex; Punishment; Rattus; Reinforcement Schedule; Resistance; Rewards; Role; Running; Schedule; Stress; Structure; System; Testing; Thalamic structure; Training; Work; addiction; cell type; cholinergic; cocaine self-administration; designer receptors exclusively activated by designer drugs; drug seeking behavior; experimental study; flexibility; high reward; optogenetics; recruit; relating to nervous system; response; stem; treatment strategy

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项目成果

Punishment resistance for cocaine is associated with inflexible habits in rats.

老鼠对可卡因的惩罚抵抗与不灵活的习惯有关。

• DOI: 10.1101/2023.06.08.544242
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Jones,BradleyO;Paladino,MorganS;Cruz,AdelisM;Spencer,HaleyF;Kahanek,PaytonL;Scarborough,LaurenN;Georges,SandraF;Smith,RachelJ
• 通讯作者: Smith,RachelJ

Discriminating goal-directed and habitual cocaine seeking in rats using a novel outcome devaluation procedure.

• DOI: 10.1101/lm.053621.122
• 发表时间: 2022-12
• 期刊: LEARNING & MEMORY
• 影响因子: 2
• 作者: Jones, Bradley O.;Cruz, Adelis M.;Kim, Tabitha H.;Spencer, Haley F.;Smith, Rachel J.
• 通讯作者: Smith, Rachel J.

New directions in modelling dysregulated reward seeking for food and drugs.

• DOI: 10.1016/j.neubiorev.2021.10.043
• 发表时间: 2022-01
• 期刊: Neuroscience and biobehavioral reviews
• 影响因子: 8.2
• 作者: Brown RM;Dayas CV;James MH;Smith RJ
• 通讯作者: Smith RJ