Data Management and Analysis Core

数据管理与分析核心

• 批准号: 10627597
• 负责人: Anna Peljto
• 金额: $ 15.64万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627597
• 关键词: Bioinformatics; Biometry; Cell Culture Techniques; Cells; Collaborations; Communication; Complex; Consultations; Cost Savings; Data; Data Analyses; Data Management Resources; Data Set; Data Storage and Retrieval; Database Management Systems; Databases; Development; Development Plans; Documentation; Ensure; Etiology; Genomics; Goals; Group Meetings; Human; Individual; Interdisciplinary Study; Knowledge; Lead; Methods; Mus; Positioning Attribute; Process; Productivity; Protocols documentation; Pulmonary Fibrosis; Quality Control; Recording of previous events; Reporting; Research; Research Design; Research Personnel; Resource Sharing; Resources; Secure; Statistical Data Interpretation; Testing; Work; cost; data cleaning; data exchange; data format; data integration; data integrity; data management; data repository; data sharing; data sharing networks; design; digital imaging; experience; experimental study; lung injury; meetings; member; organizational structure; programs; repository; single-cell RNA sequencing; skills; transcriptome sequencing; transcriptomics

ABSTRACT The Data Management and Analysis Core (DMAC) is designed to provide a shared resource for data management and analysis across projects, and to facilitate the integration and sharing of data and analytic resources. By centralizing these activities, we will ensure the integrity of the data produced by each project, create efficiencies through sharing of data and analytic resources, and provide biostatistical consultation that incorporates an in-depth knowledge of pulmonary fibrosis etiology. This strategy will also allow us to coordinate study design and data management issues, leading to a more coherent approach to data analysis, as well as significant cost savings The Core Lead (Peljto) will supervise a team that is experienced in the conduct of studies involving multidisciplinary research. The team also has the skill set required to manage complex issues of study design, multifaceted database management, genomics, and broad quantitative methods. The key activities of the DMAC will be 1) providing study design consultation and refinement, 2) providing a secure, central repository and quality control for data generated, 3) conducting biostatistical and bioinformatics analyses to test proposed hypotheses 4) facilitating integration and sharing of Project data and analytic resources. These activities will directly serve all four projects through study design consultation and analysis. In addition, the DMAC will work closely with Cores B and C to transfer, annotate, and store data and digital images generated for each Project. Finally, this Core will coordinate with the Administrative Core, as it provides the administrative and organizational structure to support this Program, and will receive direction from the Administrative Core. This Core will interact with the Administrative Core and Project Investigators at regular meetings, such that each week Dr. Peljto and appropriate DMAC members will meet with either an individual Project team or the entire Program. These activities of the Core will assist all of the Projects and the Administrative Core in fulfilling their research, reporting, and resource sharing goals and obligations

摘要 数据管理和分析核心（DMAC）旨在为数据提供共享资源 跨项目的管理和分析，并促进数据和分析的集成和共享 资源通过集中这些活动，我们将确保每个项目产生的数据的完整性， 通过共享数据和分析资源提高效率，并提供生物统计咨询， 结合了对肺纤维化病因学的深入了解。这一战略还将使我们能够协调 研究设计和数据管理问题，导致更一致的数据分析方法，以及 核心负责人（Peljto）将监督一个在开展研究方面经验丰富的团队 涉及多学科研究。该团队还具有管理复杂研究问题所需的技能 设计，多方面的数据库管理，基因组学和广泛的定量方法。的主要活动 DMAC将1）提供研究设计咨询和改进，2）提供安全的中央存储库 3）进行生物统计学和生物信息学分析，以测试拟议的 假设4）促进项目数据和分析资源的整合和共享。这些活动将 通过研究设计咨询和分析直接服务于所有四个项目。此外，DMAC将工作 与核心B和C密切合作，以传输、注释和存储为每个项目生成的数据和数字图像。 最后，这一核心将与行政核心协调，因为它提供行政和组织方面的服务。 支持该计划的结构，并将接受行政核心的指导。这个核心将与 在定期会议上与行政核心和项目研究者一起，每周Peljto博士和 适当的DMAC成员将与单个项目团队或整个项目组会面。这些 核心的活动将协助所有项目和行政核心完成其研究，报告， 资源共享的目标和义务