EBV Genomics and Bioinformatics

核心D--项目摘要 EBV基因组学和生物信息学核心D的目标将是提供统一的、以EBV为中心的功能 为该计划内的所有研究项目提供基因组方法学和综合生物信息学支持。堆芯 D提出了两个具体目标：1)开发和实施功能基因组方法来研究病毒和 使用各种下一代测序(NGS)方法的宿主基因组和表观基因组；以及2)提供 通过一个负责数据管理、质量控制、 分析，并在计划内传输。服务范围将包括：1)提供专业知识和能力 在包括RNA-Seq、ChIP-和ATAC-Seq文库制备的mRNA表达的基因组方法中， 由RBBS和HIC进行的DNA甲基化研究；2)确保跨项目的“组学”工作无缝协调 随着他们对EBV产生新的见解并执行综合分析以结合来自不同 跨不同项目的实验；3)协助完成期末报告、摘要、手稿和未来 资金建议。Core D的广泛、长期目标是：提供尖端的功能基因组学和 为计划成员提供全面的生物信息学和数据管理支持，并适当存放在 公共数据库存储库。

CORE D – PROJECT SUMMARY The goal of the EBV Genomics and Bioinformatics Core D will be to provide unified, EBV-centric functional genomic methodologies and integrative bioinformatics support to all research Projects within the Program. Core D proposes two Specific Aims: 1) develop and implement functional genomic approaches to study viral and host genomes and epigenomes using diverse Next Generation Sequencing (NGS) approaches; and 2) provide bioinformatic support for each Project through a centralize hub responsible for data management, quality control, analysis, and transfer within the program. The scope of service will include: 1) providing expertise and capabilities in genomic approaches including mRNA expression by RNA-seq, CHIP- and ATAC-seq library preparations, DNA methylation studies by RBBS, and HiC ; 2) ensuring seamless coordination of ‘omics’ efforts across projects as they develop new insights about EBV and performing integrative analyses to combine data from different experiments across the various projects; and 3) assisting with final reports, abstracts, manuscripts, and future funding proposals. Core D’s broad, long-term objective is: to provide leading-edge functional genomics and comprehensive bioinformatics and data management support for the Program members, and proper deposit in public database repositories.