Training Grant on Alzheimer's Disease and ADRD at Indiana University

该计划的总体目标是提供阿尔茨海默病的多学科培训 为博士前和博士后学员提供疾病和 AD 相关痴呆 (AD/ADRD)， 培养急需的转化劳动力来开发有效的治疗方法。的 印第安纳大学医学院 (IUSM) 的 AD/ADRD 研究获得全国认可。 IUSM 相关中心包括印第安纳阿尔茨海默病研究中心、 国家阿尔茨海默病细胞存储库、印第安纳州神经影像中心、 Regenstrief 研究所和老龄化研究中心。重要的是，NIA 最近资助了 MODEL-AD 中心、阿尔茨海默病药物研发中心和 IUSM 指导的 早发性阿尔茨海默病纵向研究。 IUSM 在最先进的设施、仪器和 过去 4 年聘用了 10 名新的 AD/ADRD 教员。此 T32 应用程序已征集 25 参与的教师具有广泛的专业知识，包括数据科学、非侵入性 成像、动物模型的开发和研究、基因组学、流行病学、药物 开发和发现，以及临床研究和试验。这些师资力量都非常出色 导师，资助总额为 4200 万美元（每年每名教员 169 万美元）。 该申请要求为 4 名博士前培训生和 4 名博士后培训生提供资助。我们将招募 具有不同背景的学员，并培训他们进行 AD/ADRD 研究与当代 使用最先进的仪器的方法和方法。博士前实习生 是从 IUSM 招募的医学神经科学研究生项目的研究生 印第安纳生物医学门户研究生项目和医学博士/博士项目。定向招聘 具有不同背景的博士后培训生是通过我们的网站非正式地实现的， 以及在国家和区域会议上。 MedNeuro 研究生项目的注册人数已 自2017年以来增加了一倍，参与教师的博士后数量也增加了 从4个增加到27个。 博士前培训计划包括神经科学的基础课程， 神经退行性疾病、数据科学以及选修研究。博士后实习生 提供数据科学方面的教学培训。 NIA 赞助的 IUSM 中心和资源使学员能够从事新的工作 疾病模型、先进的药物发现技术以及临床环境。这个职位 学员进行创新的基础、转化和临床 AD/ADRD 研究。

The overall goal of the program is to provide multidisciplinary training in Alzheimer’s disease and AD-related dementias (AD/ADRD) to predoctoral and postdoctoral trainees, producing a critically-needed translational workforce for developing effective treatments. The Indiana University School of Medicine (IUSM) is nationally recognized for AD/ADRD research. IUSM-associated centers include the Indiana Alzheimer’s Disease Research Center, the National Cell Repository for Alzheimer’s Disease, the Indiana Center for Neuroimaging, the Regenstrief Institute and the Center for Aging Research. Importantly, the NIA recently funded the MODEL-AD Center, the Alzheimer’s Disease Drug Discovery Center, and the IUSM-directed Longitudinal Early-Onset Alzheimer’s Disease Study. IUSM has invested significantly in state-of-the-art facilities, instrumentation, and the hiring of 10 new AD/ADRD faculty over the past 4 years. This T32 application has enlisted 25 participating faculty with a broad range of expertise including data science, non-invasive imaging, the development and study of animal models, genomics, epidemiology, drug development and discovery, and clinical studies and trials. These faculty are exceptional mentors and are funded at $42M total ($1.69M/faculty annually). This application requests funding for 4 pre- and 4 post-doctoral trainees. We will recruit trainees with diverse backgrounds and train them in AD/ADRD research with contemporary approaches and methodologies using state-of-the-art instrumentation. The predoctoral trainees are graduate students in the Medical Neuroscience Graduate Program, recruited from the IUSM Indiana Biomedical Gateway graduate program and the MD/PhD program. Targeted recruiting of postdoctoral trainees with diverse backgrounds is achieved informally, through our website, and at national and regional meetings. Enrollment in the MedNeuro Graduate Program has doubled since 2017 and the number of postdoctoral fellows with participating faculty has increased from 4 to 27. The predoctoral training program consists of foundational course work in neuroscience, neurodegenerative diseases, and data science along with elective studies. Postdoctoral trainees are offered didactic training in data science. The NIA-sponsored centers and resources at IUSM allow trainees to work on new disease models, advanced drug-discovery technologies, and in clinical settings. This positions trainees to conduct innovative basic, translational, and clinical AD/ADRD research.