Training Grant on Alzheimer's Disease and ADRD at Indiana University

印第安纳大学阿尔茨海默病和 ADRD 培训补助金

• 批准号: 10627778
• 负责人: GARY E. LANDRETH
• 金额: $ 51.26万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627778
• 关键词: Alzheimer' s Disease; Alzheimer' s disease related dementia; Grant; Indiana; Training; Universities

The overall goal of the program is to provide multidisciplinary training in Alzheimer’s disease and AD-related dementias (AD/ADRD) to predoctoral and postdoctoral trainees, producing a critically-needed translational workforce for developing effective treatments. The Indiana University School of Medicine (IUSM) is nationally recognized for AD/ADRD research. IUSM-associated centers include the Indiana Alzheimer’s Disease Research Center, the National Cell Repository for Alzheimer’s Disease, the Indiana Center for Neuroimaging, the Regenstrief Institute and the Center for Aging Research. Importantly, the NIA recently funded the MODEL-AD Center, the Alzheimer’s Disease Drug Discovery Center, and the IUSM-directed Longitudinal Early-Onset Alzheimer’s Disease Study. IUSM has invested significantly in state-of-the-art facilities, instrumentation, and the hiring of 10 new AD/ADRD faculty over the past 4 years. This T32 application has enlisted 25 participating faculty with a broad range of expertise including data science, non-invasive imaging, the development and study of animal models, genomics, epidemiology, drug development and discovery, and clinical studies and trials. These faculty are exceptional mentors and are funded at $42M total ($1.69M/faculty annually). This application requests funding for 4 pre- and 4 post-doctoral trainees. We will recruit trainees with diverse backgrounds and train them in AD/ADRD research with contemporary approaches and methodologies using state-of-the-art instrumentation. The predoctoral trainees are graduate students in the Medical Neuroscience Graduate Program, recruited from the IUSM Indiana Biomedical Gateway graduate program and the MD/PhD program. Targeted recruiting of postdoctoral trainees with diverse backgrounds is achieved informally, through our website, and at national and regional meetings. Enrollment in the MedNeuro Graduate Program has doubled since 2017 and the number of postdoctoral fellows with participating faculty has increased from 4 to 27. The predoctoral training program consists of foundational course work in neuroscience, neurodegenerative diseases, and data science along with elective studies. Postdoctoral trainees are offered didactic training in data science. The NIA-sponsored centers and resources at IUSM allow trainees to work on new disease models, advanced drug-discovery technologies, and in clinical settings. This positions trainees to conduct innovative basic, translational, and clinical AD/ADRD research.

该计划的总体目标是提供阿尔茨海默氏症的多学科培训 疾病和AD相关痴呆（AD/ADRD）的博士前和博士后学员， 为开发有效的治疗方法培养急需的翻译人才。的 印第安纳州大学医学院（IUSM）是全国公认的AD/ADRD研究。 与IUSM相关的中心包括印第安纳州阿尔茨海默病研究中心、 国家阿尔茨海默病细胞库，印第安纳州神经影像中心， Regenstrief研究所和老龄化研究中心。重要的是，NIA最近资助了 模型AD中心，阿尔茨海默病药物发现中心，以及IUSM指导的 早发型阿尔茨海默病纵向研究。 IUSM在最先进的设施、仪器和设备方面进行了大量投资， 在过去的四年里，招聘了10名新的AD/ADRD教师。此T32应用程序已招募25名 参与教师具有广泛的专业知识，包括数据科学，非侵入性 成像，动物模型的开发和研究，基因组学，流行病学，药物 开发和发现，以及临床研究和试验。这些教师都是杰出的 导师和资助总额为4200万美元（每年169万美元/教师）。 该申请要求资助4名博士前和4名博士后学员。我们将招募 学员有不同的背景，并培训他们在AD/ADRD研究与当代 使用最先进仪器的方法和手段。博士前培训生 是医学神经科学研究生课程的研究生，从IUSM招募 印第安纳州生物医学网关研究生课程和MD/PhD课程。定向招聘 具有不同背景的博士后学员的非正式实现，通过我们的网站， 以及国家和区域会议。MedNeuro研究生课程的入学人数 自2017年以来翻了一番，参与教师的博士后研究员人数增加了 从4个增加到27个。 博士前培训计划包括神经科学的基础课程， 神经退行性疾病和数据科学沿着选修研究。博士后研究生 提供数据科学的教学培训。 NIA赞助的中心和IUSM的资源允许受训者在新的 疾病模型，先进的药物发现技术，以及临床环境。这确定 学员进行创新的基础，转化和临床AD/ADRD研究。

项目成果

Cortico-subcortical interactions in overlapping communities of edge functional connectivity.

边缘功能连通性重叠社区中的皮质 - 皮质相互作用。

• DOI: 10.1016/j.neuroimage.2022.118971
• 发表时间: 2022-04-15
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Chumin, Evgeny J.;Faskowitz, Joshua;Esfahlani, Farnaz Zamani;Jo, Youngheun;Merritt, Haily;Tanner, Jacob;Cutts, Sarah A.;Pope, Maria;Betzel, Richard;Sporns, Olaf
• 通讯作者: Sporns, Olaf

Impaired spatial memory in adult vitamin D deficient BALB/c mice is associated with reductions in spine density, nitric oxide, and neural nitric oxide synthase in the hippocampus.

• DOI: 10.3934/neuroscience.2022004
• 发表时间: 2022
• 期刊: AIMS neuroscience
• 影响因子: 2.7
• 作者: Al-Amin MM;Sullivan RKP;Alexander S;Carter DA;Bradford D;Burne THJ
• 通讯作者: Burne THJ