Training Grant on Alzheimer's Disease and ADRD at Indiana University

该计划的总体目标是提供阿尔茨海默氏症的多学科培训 向博士后和博士后实习生提供疾病和AD相关痴呆(AD/ADRD)， 培养一支急需的翻译劳动力，以开发有效的治疗方法。这个 印第安纳大学医学院(IUSM)是全国公认的AD/ADRD研究机构。 与IUSM相关的中心包括印第安纳州阿尔茨海默病研究中心 国家阿尔茨海默氏症细胞库，印第安纳神经成像中心， 雷根斯特里夫研究所和老龄化研究中心。重要的是，NIA最近资助了 模型-AD中心、阿尔茨海默病药物研发中心和IUSM指导的 早发性阿尔茨海默病的纵向研究。 Iusm在最先进的设施、仪器设备和 在过去4年中招聘了10名新的AD/ADRD教员。此T32应用程序已招募了25人 具有广泛专业知识的参与教员，包括数据科学、非侵入性 成像、动物模型的开发和研究、基因组学、流行病学、药物 开发和发现以及临床研究和试验。这些教职员工是杰出的。 导师和资助总额为4200万美元(每位教职员工每年169万美元)。 本申请申请资助4名博士后和4名博士后实习生。我们将招募 不同背景的受训者，并在AD/ADRD研究方面与当代 使用最先进的仪器设备的途径和方法。博士后实习生 医学神经科学研究生项目的研究生是从IUSM招收的吗 印第安纳州生物医学门户研究生课程和医学博士课程。定向招聘 通过我们的网站，非正式地实现了对不同背景的博士后实习生的培训， 以及在国家和地区会议上。参加MedNeuro研究生项目的学生已经 自2017年以来翻了一番，参与教职的博士后研究员数量 从4个增加到27个。 博士前培训计划包括神经科学的基础课程工作， 神经退行性疾病、数据科学以及选修研究。博士后实习生 提供数据科学方面的教学培训。 NIA赞助的中心和IUSM的资源允许学员在新的 疾病模型、先进的药物发现技术和临床环境。这个职位 受训人员进行创新的基础、翻译和临床AD/ADRD研究。

The overall goal of the program is to provide multidisciplinary training in Alzheimer’s disease and AD-related dementias (AD/ADRD) to predoctoral and postdoctoral trainees, producing a critically-needed translational workforce for developing effective treatments. The Indiana University School of Medicine (IUSM) is nationally recognized for AD/ADRD research. IUSM-associated centers include the Indiana Alzheimer’s Disease Research Center, the National Cell Repository for Alzheimer’s Disease, the Indiana Center for Neuroimaging, the Regenstrief Institute and the Center for Aging Research. Importantly, the NIA recently funded the MODEL-AD Center, the Alzheimer’s Disease Drug Discovery Center, and the IUSM-directed Longitudinal Early-Onset Alzheimer’s Disease Study. IUSM has invested significantly in state-of-the-art facilities, instrumentation, and the hiring of 10 new AD/ADRD faculty over the past 4 years. This T32 application has enlisted 25 participating faculty with a broad range of expertise including data science, non-invasive imaging, the development and study of animal models, genomics, epidemiology, drug development and discovery, and clinical studies and trials. These faculty are exceptional mentors and are funded at $42M total ($1.69M/faculty annually). This application requests funding for 4 pre- and 4 post-doctoral trainees. We will recruit trainees with diverse backgrounds and train them in AD/ADRD research with contemporary approaches and methodologies using state-of-the-art instrumentation. The predoctoral trainees are graduate students in the Medical Neuroscience Graduate Program, recruited from the IUSM Indiana Biomedical Gateway graduate program and the MD/PhD program. Targeted recruiting of postdoctoral trainees with diverse backgrounds is achieved informally, through our website, and at national and regional meetings. Enrollment in the MedNeuro Graduate Program has doubled since 2017 and the number of postdoctoral fellows with participating faculty has increased from 4 to 27. The predoctoral training program consists of foundational course work in neuroscience, neurodegenerative diseases, and data science along with elective studies. Postdoctoral trainees are offered didactic training in data science. The NIA-sponsored centers and resources at IUSM allow trainees to work on new disease models, advanced drug-discovery technologies, and in clinical settings. This positions trainees to conduct innovative basic, translational, and clinical AD/ADRD research.