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Multidisciplinary Training in Molecular Endocrinology

分子内分泌学多学科培训

基本信息

批准号：
10627074
负责人：
Richard M O'Brien
金额：
$ 68.06万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-07-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10627074
关键词：
Endocrinology Molecular Training multidisciplinary

项目摘要

Summary This proposal requests continued support for the Molecular Endocrinology Training Program (METP) at Vanderbilt University. Progress towards understanding and curing obesity, diabetes and many other diseases requires the training of the next generation of scientists with expertise in molecular endocrinology, the goal of this program. The METP comprises 29 faculty members from 5 science departments. Of this group 24 are established faculty with substantial training experience and a track record of running well-funded programs and 5 are new investigators; 6 of these preceptors are female and 8 are from underrepresented minority groups. The METP preceptors constitute an unusually diverse and talented group of individuals whose work covers the spectrum of molecular endocrinology. These preceptors conduct research in the general areas of: 1) signal transduction 2) metabolic regulation and 3) pancreatic islet cell development and function. The request for funding of a steady state level of 8 predoctoral and 4 postdoctoral trainees is justified on the basis of the number, size and quality of the research programs directed by the preceptors and the Institutional commitment to continue the same level of trainee recruitment despite the tough economic climate. All METP trainees are appointed upon the advice of a Steering Committee after being nominated by a preceptor. Postdoctoral trainees have a Ph.D. degree. Rigorous in-depth research training is the focus of both the pre- and postdoctoral training programs. However, the METP also ensures that all trainees receive a broad didactic education. Predoctoral training in the METP usually follows that received in the Interdisciplinary Graduate Program (IGP). The IGP recruits almost all predoctoral trainees in the biomedical sciences at Vanderbilt, provides a first year core curriculum, safety training and formal evaluation and career counseling programs. This centralized recruitment has considerably increased the number and quality of predoctoral students that enter Vanderbilt. After four laboratory rotations predoctoral students choose a preceptor for their thesis project and compete for METP support. The IGP and METP have been very successful in promoting diversity and both provide ongoing training in the Responsible Conduct of Research and Rigor. All METP trainees attend an annual METP Day retreat, trainee-run data clubs and the Vanderbilt Diabetes Center (VDC) seminar series where they meet with visiting scientists. In conjunction with the Juvenile Diabetes Research Foundation, the METP initiated a novel strategy to increase the recruitment of disabled individuals, specifically undergraduates with type 1 diabetes, through the creation of a VDC-funded Summer Diabetes Research Program. The METP has already successfully trained 173 individuals of whom 128 have gone onto careers involving science with another 45 individuals still in training.

总结该提案要求继续支持分子内分泌学培训计划（METP）在范德比尔特大学。了解和治疗肥胖、糖尿病和糖尿病的进展许多其他疾病需要下一代科学家的培训，分子内分泌学，这个项目的目标METP由来自5个国家的29名教师组成科学部门。其中24人是具有丰富培训经验和 5名是新的研究人员;其中6名导师是其中8人是女性，8人来自代表性不足的少数群体。METP教师组成了一个一群异常多样化和才华横溢的人，他们的工作涵盖了分子光谱，内分泌学。这些导师在以下一般领域进行研究：1）信号转导2）代谢调节和3）胰岛细胞发育和功能。关于资助一个 8名博士前研究生和4名博士后研究生的稳态水平是合理的，由导师指导的研究项目的规模和质量以及机构承诺尽管经济形势严峻，但仍将继续招聘同等水平的实习生。所有METP 学员由导师提名，并经督导委员会建议后获委任。博士后培训生拥有博士学位。℃下严谨深入的研究训练是双方的重点博士前和博士后培训计划。然而，METP还确保所有学员都能获得广泛的说教式教育。在METP的博士前培训通常遵循在跨学科研究生课程（IGP）。IGP几乎招募了所有的博士前学员，生物医学科学在范德比尔特，提供第一年的核心课程，安全培训和正式的评估和职业咨询计划。这种集中招聘的情况大大增加进入范德比尔特的博士预科生的数量和质量。经过四次实验室轮换博士前学生选择他们的论文项目导师，并为METP支持竞争。的综合性别政策和教育培训方案在促进多样性方面非常成功，负责任的研究行为和严谨性。所有METP学员参加每年的METP日务虚会，受训者运行的数据俱乐部和范德比尔特糖尿病中心（VDC）研讨会系列，他们会见来访的科学家。与青少年糖尿病研究基金会，METP 启动了一项新的战略，以增加残疾人的招聘，特别是患有1型糖尿病的大学生，通过创建一个由VDC资助的夏季糖尿病研究计划。METP已经成功培训了173人，其中128人已经参加了培训。与另外45名仍在接受培训的人一起从事涉及科学的职业。

项目成果

期刊论文数量（186）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Mutations underlying Episodic Ataxia type-1 antagonize Kv1.1 RNA editing.

DOI：
10.1038/srep41095
发表时间：
2017-02-20
期刊：
Scientific reports
影响因子：
4.6
作者：
Ferrick-Kiddie EA;Rosenthal JJ;Ayers GD;Emeson RB
通讯作者：
Emeson RB

Increases in bioactive lipids accompany early metabolic changes associated with β-cell expansion in response to short-term high-fat diet.

生物活性脂质的增加伴随着与β细胞扩张相关的早期代谢变化，以响应短期高脂肪饮食。

DOI：
10.1152/ajpendo.00001.2018
发表时间：
2018
期刊：
American journal of physiology. Endocrinology and metabolism
影响因子：
0
作者：
Seferovic,MaximD;Beamish,ChristineA;Mosser,RockannE;Townsend,ShannonE;Pappan,Kirk;Poitout,Vincent;Aagaard,KjerstiM;Gannon,Maureen
通讯作者：
Gannon,Maureen

MafA and MafB regulate Pdx1 transcription through the Area II control region in pancreatic beta cells.

MafA 和 MafB 通过胰腺 β 细胞中的 II 区控制区调节 Pdx1 转录。

DOI：
10.1074/jbc.m802902200
发表时间：
2008
期刊：
The Journal of biological chemistry
影响因子：
0
作者：
Vanhoose,AmandaM;Samaras,Susan;Artner,Isabella;Henderson,Eva;Hang,Yan;Stein,Roland
通讯作者：
Stein,Roland

Portal glucose delivery stimulates muscle but not liver protein metabolism.

门脉葡萄糖输送刺激肌肉但不刺激肝脏蛋白质代谢。

DOI：
10.1152/ajpendo.00140.2012
发表时间：
2012
期刊：
American journal of physiology. Endocrinology and metabolism
影响因子：
0
作者：
Kraft,Guillaume;Coate,KatieC;Dardevet,Dominique;Farmer,Ben;Donahue,EPatrick;Williams,PhillipE;Cherrington,AlanD;Moore,MaryCourtney
通讯作者：
Moore,MaryCourtney

Cutting edge: influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells.