Administrative Core

交流摘要摘要 行政核心(行政核心)将向其他核心和项目提供必要的支持和协调。 SARS-CoV-2感染与祖先基因组变异相互作用的研究 阿尔茨海默病(ISAVRAD)。AC将监督U-19的整个科学方向，管理其 资源，把四项科研活动与六项服务活动结合起来 核心。在业务上，咨询委员会将与临床核心合作，管理从 相关核心的收集地点，管理测序中心和DNA之间的关系 监督国际地点的合规和协调，并协调 核心，包括它们与科学项目交换的数据/材料。五个已成立的委员会将 监督咨询委员会的活动：领导、长期规划、科学管理、财政和 管理监督和出版。咨询委员会的目标有四个。首先，我们将管理ISAVRAD 以及它与核心和项目负责人的内部关系，包括5 Data的负责人 收藏网站。具体地说，咨询委员会将建立和重新审查及时的计划优先事项，优化共享 核心和项目之间的资源，审查数据和标本管理需求，进行科学交流 取得进展，促进与ISAVRAD内其他老龄计划的科学关系和合作 网络，并监督道德和法律问题(IRB等)。其次，CC将管理ISAVRAD关系 在机构间防灾减灾战略的外部，包括与外部咨询委员会成员沟通， 与其他老龄化研究沟通、协调和合作，以确定新的和正在出现的领域 与ISAVRAD目标相关的科学调查；监督编写年度进展报告 国家老龄问题研究所；监督与外部机构的调查人员共享资源(例如， 数据/材料使用协议)；在所有招聘地点促进与社区居民的接触，以 传播当前关于健康、ADRD和生活方式的主题，并向研究传播科学发现 社区。第三，AC将与临床、神经成像、数据管理和统计部门合作 确保统一征聘、数据收集、数据存储和管理的核心，以及 数据/材料在整个ISAVRAD联合体中传输。第四，咨询委员会将监督教师的发展 与U-19相关的每个学术中心的活动，包括有组织的面对面指导和 出席会议/会议。

AC Summary Abstract The Administrative Core (AC) will provide essential support and coordination to the other Cores and Projects of the Study on Interactions between SARS-CoV-2 infection and Ancestral genomic Variations in the Risk of Alzheimer's Disease (ISAVRAD). The AC will oversee the entire scientific direction of the U-19, manage its resources, and integrate the scientific research activities of the four Projects with the service activities of the six Cores. Operationally, the AC, in collaboration with the Clinical Core, will manage the transfer of samples from collection sites to the pertinent Cores, manage relationships between the sequencing centers and DNA repositories, oversee compliance and harmonization at international sites, and coordinate the activities of the Cores, including their data/materials exchanges with the scientific Projects. Five established committees will oversee the activities of the AC: Leadership, Long- Term Planning, Scientific Administrative, Fiscal & Management Oversight, and Publications. The aims of the AC are four-fold. First, we will manage the ISAVRAD and its internal relationships with the leaders of the Cores and Projects, including the leaders at the 5 data collection sites. Specifically, the AC will establish and revisit timely program priorities, optimize the sharing of resources among Cores and Projects, review data and specimen management needs, communicate scientific advances, promote scientific relationships and collaborations with other aging programs within the ISAVRAD network, and oversee ethical and legal issues (IRB etc.). Second, the CC will manage ISAVRAD relationships external to ISAVRAD, including communicating with the External Advisory Committee members, communicating, coordinating and collaborating with other aging studies to identify new and emerging areas of scientific inquiry relevant to the goals of ISAVRAD; oversee the preparation of annual progress reports for the National Institute on Aging; oversee the sharing of resources with investigators at outside institutions (e.g., data/material usage agreements); promote outreach to community residents at all recruitment sites to disseminate current topics on health, ADRD, and lifestyles, and disseminate scientific findings to the research community. Third, the AC will work with the Clinical, Neuroimaging, and Data Management and Statistics Cores to ensure harmonization of recruitment, data collection, data storage and management, and data/materials transfers throughout the ISAVRAD consortium. Fourth, the AC will oversee faculty development activities at each academic center affiliated with this U-19, including structured in-person mentoring and attendance at meetings/conferences.