Administrative Core

行政核心

• 批准号: 10628506
• 负责人: GABRIEL Alejandro DE ERAUSQUIN
• 金额: $ 314.42万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628506
• 关键词: Advisory Committees; Aging; Agreement; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Area; Assessment tool; Biocompatible Materials; Biological; Biological Markers; Clinical; Cognitive aging; Collaborations; Committee Members; Communication; Communities; DNA Repository; Data; Data Collection; Data Storage and Retrieval; Development; Elderly; Ensure; Environment; Ethics; Event; Exposure to; Faculty; Genes; Genetic Variation; Goals; Health; Impaired cognition; Individual; Institution; Institutional Review Boards; International; Leadership; Legal; Life Style; Mediation; Medical; Mentors; Methods; National Institute on Aging; Outcome; Persons; Population; Preparation; Progress Reports; Publications; Recommendation; Research; Research Activity; Research Personnel; Resource Sharing; Resources; Risk; SARS-CoV-2 exposure; SARS-CoV-2 infection; Scientific Advances and Accomplishments; Scientific Inquiry; Services; Site; Specimen; Structure; Suggestion; Teacher Professional Development; Time Management; Underrepresented Populations; Visit; Work; Writing; career; cohort; comparison group; data collection site; data management; follow-up; genomic variation; lifestyle factors; meetings; neuroimaging; operation; outreach; programs; psychosocial; recruit; responsible research conduct; sample collection; statistics; symposium

AC Summary Abstract The Administrative Core (AC) will provide essential support and coordination to the other Cores and Projects of the Study on Interactions between SARS-CoV-2 infection and Ancestral genomic Variations in the Risk of Alzheimer's Disease (ISAVRAD). The AC will oversee the entire scientific direction of the U-19, manage its resources, and integrate the scientific research activities of the four Projects with the service activities of the six Cores. Operationally, the AC, in collaboration with the Clinical Core, will manage the transfer of samples from collection sites to the pertinent Cores, manage relationships between the sequencing centers and DNA repositories, oversee compliance and harmonization at international sites, and coordinate the activities of the Cores, including their data/materials exchanges with the scientific Projects. Five established committees will oversee the activities of the AC: Leadership, Long- Term Planning, Scientific Administrative, Fiscal & Management Oversight, and Publications. The aims of the AC are four-fold. First, we will manage the ISAVRAD and its internal relationships with the leaders of the Cores and Projects, including the leaders at the 5 data collection sites. Specifically, the AC will establish and revisit timely program priorities, optimize the sharing of resources among Cores and Projects, review data and specimen management needs, communicate scientific advances, promote scientific relationships and collaborations with other aging programs within the ISAVRAD network, and oversee ethical and legal issues (IRB etc.). Second, the CC will manage ISAVRAD relationships external to ISAVRAD, including communicating with the External Advisory Committee members, communicating, coordinating and collaborating with other aging studies to identify new and emerging areas of scientific inquiry relevant to the goals of ISAVRAD; oversee the preparation of annual progress reports for the National Institute on Aging; oversee the sharing of resources with investigators at outside institutions (e.g., data/material usage agreements); promote outreach to community residents at all recruitment sites to disseminate current topics on health, ADRD, and lifestyles, and disseminate scientific findings to the research community. Third, the AC will work with the Clinical, Neuroimaging, and Data Management and Statistics Cores to ensure harmonization of recruitment, data collection, data storage and management, and data/materials transfers throughout the ISAVRAD consortium. Fourth, the AC will oversee faculty development activities at each academic center affiliated with this U-19, including structured in-person mentoring and attendance at meetings/conferences.

AC摘要 行政核心（AC）将为其他核心和项目提供必要的支持和协调， SARS-CoV-2感染与祖先基因组变异在SARS发病风险中的交互作用研究 阿尔茨海默病（ISAVRAD）。AC将监督U-19的整个科学方向， 资源，并将四个项目的科研活动与六个项目的服务活动相结合。 丹在操作上，AC与临床核心合作，将管理样本从 收集站点到相关核心，管理测序中心和DNA之间的关系 监督国际站点的遵守和协调，并协调 核心，包括与科学项目的数据/材料交换。五个常设委员会将 监督审计委员会的活动：领导、长期规划、科学管理、财政和 管理监督和出版物。AC的目标有四个方面。首先，我们将管理ISAVRAD 及其与核心和项目领导的内部关系，包括5个数据的领导 收集网站。具体而言，咨询委员会将建立和重新审查及时的方案优先事项， 核心和项目之间的资源，审查数据和标本管理需求， 在ISAVRAD内，促进与其他老龄化项目的科学关系和合作 网络，并监督伦理和法律的问题（IRB等）。第二，CC将管理ISAVRAD关系 国际民用航空安全和防空司令部的外部，包括与外部咨询委员会成员的沟通， 与其他老龄化研究进行沟通、协调和合作，以确定新的和新兴的老龄化研究领域。 与ISAVRAD目标相关的科学调查;监督年度进展报告的编写， 国家老龄问题研究所;监督与外部机构（例如， 数据/材料使用协议）;在所有征聘地点促进与社区居民的外联， 传播关于健康、ADRD和生活方式的当前主题，并将科学发现传播给研究人员 社区第三，AC将与临床、神经影像、数据管理和统计部门合作 确保征聘、数据收集、数据储存和管理协调一致的核心， 数据/材料在ISAVRAD联合体中的传输。第四，AC将监督教师发展 活动在每个学术中心附属于这个U-19，包括结构化的亲自指导， 出席各种会议。