Administrative Core

AC 摘要摘要 行政核心 (AC) 将为其他核心和项目提供必要的支持和协调 SARS-CoV-2 感染与祖先基因组变异风险之间的相互作用研究 阿尔茨海默病（ISAVRAD）。 AC 将监督 U-19 的整个科学方向，管理其 整合资源，将四个项目的科研活动与六个项目的服务活动结合起来 核心。在操作上，AC 将与临床核心合作，管理样本的转移 收集站点到相关核心，管理测序中心和 DNA 之间的关系 存储库，监督国际站点的合规性和协调性，并协调 核心，包括与科学项目的数据/材料交换。成立五个委员会 监督审计委员会的活动：领导、长期规划、科学管理、财政和 管理监督和出版物。审计委员会的目标有四个。首先，我们将管理 ISAVRAD 及其与核心和项目领导者的内部关系，包括 5 个数据的领导者 收集网站。具体来说，审计委员会将及时确定并重新审视计划优先事项，优化资源共享 核心和项目之间的资源，审查数据和样本管理需求，沟通科学 进步，促进与 ISAVRAD 内其他老龄化项目的科学关系和合作 网络，并监督道德和法律问题（IRB 等）。其次，CC将管理ISAVRAD关系 ISAVRAD 外部，包括与外部咨询委员会成员沟通， 与其他老龄化研究进行沟通、协调和合作，以确定新的和正在出现的领域 与 ISAVRAD 目标相关的科学探究；监督年度进度报告的编制 国家老龄化研究所；监督与外部机构研究人员的资源共享（例如， 数据/材料使用协议）；在所有招聘地点促进对社区居民的宣传， 传播有关健康、ADRD 和生活方式的当前主题，并传播研究成果 社区。第三，AC 将与临床、神经影像、数据管理和统计部门合作 确保招聘、数据收集、数据存储和管理协调一致的核心，以及 整个 ISAVRAD 联盟的数据/材料传输。第四，审计委员会将监督教师发展 与该 U-19 相关的每个学术中心的活动，包括结构化的面对面指导和 出席会议/会议。

AC Summary Abstract The Administrative Core (AC) will provide essential support and coordination to the other Cores and Projects of the Study on Interactions between SARS-CoV-2 infection and Ancestral genomic Variations in the Risk of Alzheimer's Disease (ISAVRAD). The AC will oversee the entire scientific direction of the U-19, manage its resources, and integrate the scientific research activities of the four Projects with the service activities of the six Cores. Operationally, the AC, in collaboration with the Clinical Core, will manage the transfer of samples from collection sites to the pertinent Cores, manage relationships between the sequencing centers and DNA repositories, oversee compliance and harmonization at international sites, and coordinate the activities of the Cores, including their data/materials exchanges with the scientific Projects. Five established committees will oversee the activities of the AC: Leadership, Long- Term Planning, Scientific Administrative, Fiscal & Management Oversight, and Publications. The aims of the AC are four-fold. First, we will manage the ISAVRAD and its internal relationships with the leaders of the Cores and Projects, including the leaders at the 5 data collection sites. Specifically, the AC will establish and revisit timely program priorities, optimize the sharing of resources among Cores and Projects, review data and specimen management needs, communicate scientific advances, promote scientific relationships and collaborations with other aging programs within the ISAVRAD network, and oversee ethical and legal issues (IRB etc.). Second, the CC will manage ISAVRAD relationships external to ISAVRAD, including communicating with the External Advisory Committee members, communicating, coordinating and collaborating with other aging studies to identify new and emerging areas of scientific inquiry relevant to the goals of ISAVRAD; oversee the preparation of annual progress reports for the National Institute on Aging; oversee the sharing of resources with investigators at outside institutions (e.g., data/material usage agreements); promote outreach to community residents at all recruitment sites to disseminate current topics on health, ADRD, and lifestyles, and disseminate scientific findings to the research community. Third, the AC will work with the Clinical, Neuroimaging, and Data Management and Statistics Cores to ensure harmonization of recruitment, data collection, data storage and management, and data/materials transfers throughout the ISAVRAD consortium. Fourth, the AC will oversee faculty development activities at each academic center affiliated with this U-19, including structured in-person mentoring and attendance at meetings/conferences.