Core 1 - Biostatistics

核心 1 - 生物统计学

• 批准号: 10628256
• 负责人: BETH A. REBOUSSIN
• 金额: $ 30.16万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-03 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628256
• 关键词: Adolescent; Baptist Church; Bioinformatics; Biometry; Biostatistics Core; Biostatistics Shared Resource; Cardiovascular Diseases; Cataloging; Cluster randomized trial; Collaborations; Collection; Comprehensive Cancer Center; Consultations; Cross-Sectional Studies; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Element; Data Management Resources; Data Science; Data Set; Data Storage and Retrieval; Database Management Systems; Databases; Documentation; Ensure; Formulation; Funding; Health Sciences; Health behavior; Image; Individual; Infrastructure; Intervention; Laboratory Procedures; Life; Longitudinal cohort study; Malignant Neoplasms; Measurement; Metadata; Methodology; Mission; Monitor; Online Systems; Outcome; Participant; Persons; Population; Probability Samples; Procedures; Public Health; Quality Control; Randomized; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Resource Sharing; Risk Assessment; Sample Size; Sampling; Schools; Secure; Services; Statistical Data Interpretation; Stratification; Surveys; Technical Expertise; Techniques; United States National Institutes of Health; Weight; arm; benefit sharing; biomedical informatics; data cleaning; data integration; data management; data sharing; database design; design; experience; forest; health communication; medical schools; member; multidisciplinary; programs; quality assurance; recruit; relational database; skills; statistics; synergism; vaping

ABSTRACT – CORE 001: Biostatistics Core The Biostatistics Core will provide the shared biostatistical services and data coordination necessary for this Program Project. It will provide comprehensive support of the web-based surveys, lab-based studies, and the randomized cluster health communication trial from study design, sampling, data collection, quality control, and database management to biostatistical analysis and dissemination. Use of a centralized core will support the overall conceptual framework for the Program Project, resulting in consistency in measurement and analysis across studies and other cores. The Biostatistics Core draws upon the skills and expertise housed within the Department of Biostatistics and Data Science in the Division of Public Health Sciences at Wake Forest School of Medicine, a department with extensive experience serving as a data coordinating center for numerous multi- center NIH-funded studies, and from the Biostatistics Shared Resource of the Wake Forest Baptist Comprehensive Cancer Center. The mission of the Biostatistics Core is to provide a complete and well- integrated infrastructure for the collection and analysis of study data, ensuring appropriate inferences are made when disseminating results. The Aims of the core are to: 1) Provide statistical expertise on study design and sample selection; 2) Perform data management activities including database creation, quality control, integration, and sharing; and 3) Conduct statistical analyses and facilitate proper statistical inference from appropriately prepared datasets. This centralized core will provide the technical skills necessary for the collection of research data via web-based surveys and in-person laboratory procedures and will provide a skilled team for the statistical analysis of these data sets. Through a coordinated collaboration between this Core and each project, we will ensure an efficient means of collecting and analyzing data for all research projects described in this proposal. The primary objectives of the Biostatistics Core are the provision of needed biostatistical services, including design, sampling, data management, analysis, and dissemination.

摘要-核心001：生物统计学核心 生物统计核心将为此提供共享的生物统计服务和数据协调。 计划项目。它将为网上调查、实验室研究和 从研究设计、抽样、数据收集、质量控制和 数据库管理到生物统计分析和传播。使用集中式核心将支持 计划项目的总体概念框架，导致测量和分析的一致性 跨研究和其他核心。生物统计学核心利用了 维克森林学校公共卫生科学部生物统计学和数据科学系 医学部，一个拥有丰富经验的部门，作为众多多个数据协调中心， 中心NIH资助的研究，并从生物统计学共享资源的维克森林浸信会 综合癌症中心。生物统计学核心的使命是提供一个完整的和良好的- 用于收集和分析研究数据的集成基础设施，确保做出适当的推断 在传播成果时。核心的目的是：1）提供研究设计的统计专业知识， 样本选择; 2）执行数据管理活动，包括数据库创建，质量控制， 整合和共享;以及3）进行统计分析，并促进从 适当准备的数据集。这一集中的核心将提供必要的技术技能， 通过基于网络的调查和亲自实验室程序收集研究数据，并将提供 这些数据集的统计分析。通过协调合作， 核心和每个项目，我们将确保收集和分析所有研究数据的有效手段 本提案中所述的项目。生物统计核心的主要目标是提供所需的 生物统计服务，包括设计、取样、数据管理、分析和传播。