Biostatistics and Bioinformatics Core

生物统计学和生物信息学核心

• 批准号: 10628987
• 负责人: Shahidul Islam
• 金额: $ 11.89万
• 依托单位: NYU LONG ISLAND SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628987
• 关键词: Biogenesis; Bioinformatics; Biometry; Biostatistics Core; Catabolism; Collaborations; Competence; Consultations; Data; Data Analyses; Data Analytics; Data Collection; Data Reporting; Data Set; Dedications; Elements; Ensure; High Performance Computing; Human Resources; Lipoproteins; Methodology; Methods; Mus; Outcome Study; Play; Policies; Process; Protocols documentation; Publications; Quality Control; Reporting; Research Design; Role; Running; Sample Size; Sampling; Source; Standardization; Statistical Data Interpretation; Statistical Methods; System; Techniques; Validation; Work; cluster computing; data curation; data management; data quality; data sharing; data standards; instrument; meetings; member; novel; power analysis; programs; repository; sound; success

SUMMARY/ABSTRACT – BIOSTATISTICS AND BIOINFORMATICS CORE (CORE 1) The Biostatistics and Bioinformatics Core (Core 1; C1) will provide data management and analytical competencies to all projects (P1–P3) and cores (C2, C3, and the Administrative Core). C1 personnel will work closely with the other project and core leaders to support study design, data collection, management, data curation, statistical analysis, interpretation, and publication of the study outcomes. C1 will play a crucial role in creating data collection instruments and managing data in REDCap systems to ensure proper data validation. C1 personnel will also create standardized requirements and scripts to perform regular data quality checks, develop a formal data sharing protocol, and oversee the data request and distribution. The biostatistics personnel from C1 were actively involved in producing each project protocol, including sample size and power analysis. We will work with each project leader to provide state-of-the-art statistical and bioinformatics collaboration and consultation throughout the study and use novel methodologies to analyze and interpret data. We will use a high-performance computing cluster with 90 compute nodes to run all bioinformatics analyses. As an integral part of the PPG, all C1 members will attend all the PPG's monthly meetings and focus on analyzing and interpreting data generated by the projects and other cores. C1 will also educate the junior members of the PPG on biostatistics and bioinformatics methods and techniques.

总结/摘要-生物统计学和生物信息学核心（核心1） 生物统计学和生物信息学核心（核心1; C1）将提供数据管理和分析 所有项目（P1-P3）和核心（C2、C3和行政核心）的能力。C1人员将工作 与其他项目和核心负责人密切合作，以支持研究设计、数据收集、管理、数据 研究结果的管理、统计分析、解释和出版。C1将发挥关键作用， 创建数据收集工具并管理REDCap系统中的数据，以确保适当的数据验证。 C1人员还将创建标准化的要求和脚本，以执行定期的数据质量检查， 制定正式的数据共享协议，并监督数据请求和分发。生物统计 来自C1的人员积极参与制定每个项目方案，包括样本量和功效 分析.我们将与每个项目负责人合作，提供最先进的统计和生物信息学 在整个研究过程中进行合作和协商，并使用新的方法来分析和解释 数据我们将使用具有90个计算节点的高性能计算集群来运行所有生物信息学 分析。作为PPG的一个组成部分，所有C1成员将参加PPG的所有月度会议， 分析和解释项目和其他岩心产生的数据。C1还将教育初级 生物统计学和生物信息学方法和技术的PPG成员。