Genetics & Genomics Training Program

遗传学

• 批准号: 10627857
• 负责人: GAD SHAULSKY
• 金额: $ 84.89万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627857
• 关键词: Genetic; Genomics; Training Programs

This application is a request for support for the Predoctoral Training Program in Genetics & Genomics at Baylor College of Medicine. This Program started in 1987 and has been funded by an NIGMS T32 since 1990. The Graduate School and the Department of Molecular and Human Genetics follow three tenets of innovative biomedicine at Baylor College of Medicine: Research, Education, and Service. The mission of this interdepartmental Program is to train PhD students in the fundamentals of classical and modern genetics and in application of their knowledge and skills to innovations in biomedicine. Diversity and inclusion are integral components of this mission. Our objectives are to provide students with rigorous and methodical training in genetics and genomics while emphasizing research and academic excellence, and to help them become leaders among the next generation of biomedical scientists. We are currently training 97 predoctoral students, an increase of 16% in the past 5 years, and we plan to train 100 new students in the next 5 years. We currently have 84 faculty mentors, an increase of 20% in the past 5 years. Their research projects span a wide range of interests, including human genetics, genomics, the molecular basis of human disease, animal models of human disease, microbial genetics, development, neurobiology, and genome stability. The common themes among these topics are genetics and genomics, and their translation to human health. The training elements in the first year include foundational and advanced courses, laboratory rotations, and skill development activities. The courses are focused on design and analysis of genetic-based experiments and the rotations provide individualized practical research experiences. Skill development includes training in the responsible conduct of research, ethical aspects of human genetics in the genomic era, rigor and reproducibility in experimental science, scientific communications, critical thinking, and teamwork. In the second year, the students join research laboratories in which they conduct projects under the mentorship of our faculty, as they begin their path to independence. They also take a qualifying examination that trains them to integrate knowledge from courses and from the literature and to design an original experimental research project. In addition to training in experimental work, the students learn how to analyze their data, how to present their findings orally and in writing, and how to participate in the scientific process in a collegial and constructive way. The students are also encouraged to participate in career development activities throughout their training. The thesis project culminates in the preparation and defense of a thesis dissertation. The average time to a PhD degree is 5.7 years and the average number of publications is 6.1, including 2.1 first-author papers. Our retention rate is 96%, and most of our alumni use their training in their subsequent positions. We are requesting 16 slots, 8 per year for the first 2 years of training, to match our increased training capacity and the proven success of the only T32-supported Genetics & Genomics PhD Program in Texas and within a 600 mile radius of Houston.

本申请是对遗传学和基因组学博士前培训计划的支持请求，网址为 贝勒医学院。该计划始于1987年，自1990年以来一直由NIGMS T32资助。 研究生院和分子与人类遗传学系遵循创新的三个原则 贝勒医学院生物医学：研究、教育和服务。这件事的使命是 跨部门项目是培养博士生的古典和现代遗传学基础和 将他们的知识和技能应用于生物医学创新。多样性和包容性是不可分割的 这项任务的组成部分。我们的目标是为学生提供严格和有条不紊的培训 遗传学和基因组学，同时强调研究和学术卓越，并帮助它们成为 下一代生物医学科学家中的领军人物。我们目前正在培养97名博士后研究生， 过去5年增长了16%，我们计划在未来5年培养100名新生。我们目前 拥有84名教师导师，在过去的5年里增加了20%。他们的研究项目涵盖了广泛的 兴趣包括人类遗传学，基因组学，人类疾病的分子基础，动物模型 人类疾病、微生物遗传学、发育、神经生物学和基因组稳定性。共同的主题 这些话题包括遗传学和基因组学，以及它们对人类健康的影响。中的培训要素 第一年包括基础和高级课程、实验室轮换和技能发展活动。 这些课程的重点是设计和分析基于遗传的实验，旋转提供 个性化的实践研究体验。技能发展包括负责任的行为培训 研究，基因组时代人类遗传学的伦理问题，实验中的严密性和重复性 科学、科学交流、批判性思维和团队合作。在第二年，学生们加入 他们在我们教员的指导下进行项目的研究实验室，当他们开始他们的 通向独立的道路。他们还参加资格考试，训练他们整合来自 并从课程和文献中设计出原创性的实验研究项目。除了培训之外 实验工作，学生学习如何分析他们的数据，如何口头和口头表达他们的发现 写作，以及如何以合作和建设性的方式参与科学进程。学生们都是 还鼓励他们在整个培训期间参加职业发展活动。本论文项目 在准备和答辩一篇论文时达到高潮。获得博士学位的平均时间为5.7 年，平均发文6.1篇，其中第一作者论文2.1篇。我们的保留率是 96%，而且我们的大多数校友都在随后的职位上使用他们的培训。我们要求16个机位，每个机位8个 头两年的培训，以配合我们增加的培训能力和事实证明的成功 在德克萨斯州和休斯顿方圆600英里范围内，只有T32支持的遗传学和基因组学博士项目。

项目成果

Rewiring of mitochondrial metabolism in therapy-resistant cancers: permanent and plastic adaptations.

• DOI: 10.3389/fcell.2023.1254313
• 发表时间: 2023
• 期刊: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
• 影响因子: 5.5
• 作者: Pendleton, Katherine E.;Wang, Karen;Echeverria, Gloria V.
• 通讯作者: Echeverria, Gloria V.

CUB domains are not required for OVCH2 function in sperm maturation in the mouse epididymis.

• DOI: 10.1111/andr.13508
• 发表时间: 2023-08
• 期刊: Andrology
• 影响因子: 4.5
• 作者: Katarzyna Kent;K. Nozawa;Courtney Sutton;Frey Daniel;M. Ikawa;Thomas X. Garcia;M. Matzuk