Genetic and Environmental Influences on Addiction

遗传和环境对成瘾的影响

• 批准号: 10628242
• 负责人: Teresa A Milner
• 金额: $ 16.14万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628242
• 关键词: Genetic; addiction

Understanding how genetic and environmental factors impact drug use and abuse may be critical for addiction prevention and diagnosis, as well as the development of novel effective addiction therapeutics. The objective of this renewal application plans to provide 4 predoctoral training slots (for 1-2 yrs each, starting in the 2nd yr) in the Weill Cornell Graduate School (WCGS) Neuroscience and Pharmacology Programs with the rationale of understanding the impact of genes and environment on drug addiction. A unique feature of this training plan is the diversity of faculty expertise in both genetic (e.g. sex, single nucleotide polymorphisms, gene splice variants and epigenetics) and environmental (e.g., HIV positivity, materal environment, developmental age) factors that are essential for the emergence of addictive disease. Our faculty is also noteworthy for the breadth of the approaches they bring to addiction science; we have expertise in studying how several major abused drugs (i.e. alcohol, opiates, cocaine, and other psychostimulants) impact neuronal function from the expression and behavior of single molecules to the performance of complex functional systems that regulate the behavior of rodents and humans. In addition to our talented faculty, this training grant will take advantage of the WCGS outstanding research environment, educational resources, and recruiting activities, particularly our history of attracting and training under-represented minorities as basic and clinical scientists. Particular strengths of the training grant include: 1) the experience of the Director and Co-Director in mentoring, teaching and drug abuse research; 2) the broad scope of multidisciplinary research training provided by the faculty; 3) extensive collaborations and co-mentoring between the faculty; 4) the strong emphasis on “bench-to- bedside” translational research; and 5) established initiatives for promoting diversity and inclusion. Training grant faculty will be divided into three groups: 1) Major Sponsors: thesis mentors with NIDA mission supported research programs; 2) Minor Sponsors: individuals with NIDA-mission interests who will collaborate with Major Sponsors and their trainees; 3) Training Sponsors: individuals with extensive experience in drug abuse research who will work closely with Major Sponsors and their trainees. Beyond the laboratory, key activities of the training plan inlcude: 1) courses designed specifically for this T32 (“Addiction and Society” and “Challenges in Pain Management”); 2) drug abuse focused retreat; 3) WCGS developed programs in fellowhsip preparation; and 4) training experiences in teaching, mentoring, networking and career opportunites. These activities together with the existing coursework and curricula, symposia and lectures, as well as each students individual training plan, will provide a solid foundation for promoting the development of sucessful transitions of 12-15 PhD students over a period of 5 years into careers in the biomedical workforce.

了解遗传和环境因素如何影响药物使用和滥用可能对成瘾至关重要 预防和诊断，以及开发新的有效的成瘾疗法。客观 本次更新申请计划提供4个博士前培训名额（1-2年，从第二年开始）， 威尔康奈尔研究生院（WCGS）神经科学和药理学课程，其基本原理是 了解基因和环境对药物成瘾的影响。该培训计划的一个独特之处是 教师在遗传学（如性别，单核苷酸多态性，基因剪接）专业知识的多样性 变体和表观遗传学）和环境（例如，HIV阳性、物质环境、发育年龄） 这些因素对成瘾性疾病的出现至关重要。我们的教师也值得注意的广度 他们为成瘾科学带来的方法;我们在研究几种主要的滥用药物方面有专业知识。 药物（如酒精、阿片类药物、可卡因和其他精神兴奋剂）通过表达 单分子的行为和复杂功能系统的性能， 啮齿类动物和人类。除了我们有才华的教师，这项培训补助金将利用WCGS 优秀的研究环境，教育资源和招聘活动，特别是我们的历史， 吸引和培训代表性不足的少数民族作为基础和临床科学家。特别优势的 培训补助金包括：1）主任和联席主任在辅导、教学和药物滥用方面的经验 研究; 2）由教师提供的多学科研究培训的广泛范围; 3）广泛的 教师之间的合作和共同指导; 4）对“bench-to- bedside” 转化研究; 5）建立促进多样性和包容性的举措。教师培训补助金 将分为三组：1）主要赞助者：具有NIDA使命支持研究的论文导师 2）次要赞助者：与主要赞助者合作的具有NIDA使命兴趣的个人 3）培训赞助人：在药物滥用研究方面具有丰富经验的个人，他们将 与主要赞助商及其学员密切合作。在实验室之外，培训计划的主要活动 包括：1）专门为T32设计的课程（“成瘾与社会”和“疼痛的挑战 管理”）; 2）以药物滥用为重点的务虚会; 3）妇女儿童总协会制定了伙伴关系准备方案;以及4） 在教学、指导、网络和职业机会方面的培训经验。这些活动与 现有的课程和课程、专题讨论会和讲座，以及每个学生的个人培训计划， 将为促进12-15名博士生的成功过渡提供坚实的基础 在生物医学劳动力的职业生涯中度过了5年。

项目成果

Substrate binding-induced conformational transitions in the omega-3 fatty acid transporter MFSD2A.

• DOI: 10.1038/s41467-023-39088-y
• 发表时间: 2023-06-09
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Bergman, Shana;Cater, Rosemary J.;Plante, Ambrose;Mancia, Filippo;Khelashvili, George
• 通讯作者: Khelashvili, George

The fine art of preparing membrane transport proteins for biomolecular simulations: Concepts and practical considerations.

• DOI: 10.1016/j.ymeth.2020.02.009
• 发表时间: 2021-01
• 期刊: METHODS
• 影响因子: 4.8
• 作者: Shiref, Hana;Bergman, Shana;Clivio, Sophie;Sahai, Michelle A.
• 通讯作者: Sahai, Michelle A.