Brain-Behavior Mechanisms of Social Cognition in First-Episode Psychosis

首发精神病社会认知的脑行为机制

基本信息

  • 批准号:
    10740563
  • 负责人:
  • 金额:
    $ 19.2万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-08-01 至 2027-07-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Psychotic disorders are serious illnesses that lead to significant functional impairment, even during the early course of illness (i.e., first-episode psychosis; FEP). Social cognition is a strong predictor of key functional outcomes in psychosis (i.e., social and occupational functioning) and among social cognitive domains, mentalizing – the ability to infer and reason about the mental states of other people – is most robustly impaired and simultaneously most predictive of outcomes. However, existing interventions addressing social cognitive dysfunction in psychosis are minimally effective in improving real-world outcomes. Further, though psychosis studies have revealed abnormal function in brain areas comprising the mentalizing network (MN; e.g., medial prefrontal cortex and temporoparietal junction), the vast majority of existing studies have utilized fMRI paradigms that use non-human or non-interactive stimuli that may limit ecological validity and further fail to examine associations between neural function and real-world outcomes. Collectively, social cognition is a critical factor in psychosis that remains poorly understood. Thus, the proposed study will combine neural, behavioral, and real- world functioning measures to delineate brain-behavior mechanisms of social cognition in FEP. The study will enroll 45 FEP individuals and 45 matched non-clinical controls (NCC) and assess their neural (i.e., fMRI) and behavioral (i.e., validated laboratory-based measures) social cognitive function as well as their real-world social and occupational behavior. Data from this study will allow for an innovative investigation of whether MN dysfunction is associated with social cognitive performance on validated behavioral tasks both across and within FEP and NCC participants (Aim 1), and how these brain-behavior measures of social cognitive performance relate to laboratory-based measures of social and occupational functioning (Aim 2). The current study will also examine the extent to which MN function predicts real-world social and occupational functioning assessed via ecological momentary assessment (Aim 3). This proposal concurrently provides an excellent opportunity to receive mentor-directed, hands-on training in several key areas necessary to refine the candidate’s knowledge and skill-sets. Though the candidate has extensive clinical research experience in FEP and has completed foundational fMRI training, she proposes a training plan focused on three new domains: 1) advanced social- cognitive neuroscience and fMRI task development, 2), linking of fMRI to behavioral constructs of social cognition and functional outcome, and 3) translation of fMRI and behavioral constructs to psychosis. The proposed study coupled with completion of the training plan will effectively launch the candidate toward her long-term goal of an independent career in the translational neuroscience of social-cognitive dysfunction in early psychosis, and will lay the foundation for future, high-impact R01 studies focused on refined identification and targeting of biobehavioral factors influencing social and functional outcomes.
PROJECT SUMMARY Psychotic disorders are serious illnesses that lead to significant functional impairment, even during the early course of illness (i.e., first-episode psychosis; FEP). Social cognition is a strong predictor of key functional outcomes in psychosis (i.e., social and occupational functioning) and among social cognitive domains, mentalizing – the ability to infer and reason about the mental states of other people – is most robustly impaired and simultaneously most predictive of outcomes. However, existing interventions addressing social cognitive dysfunction in psychosis are minimally effective in improving real-world outcomes. Further, though psychosis studies have revealed abnormal function in brain areas comprising the mentalizing network (MN; e.g., medial prefrontal cortex and temporoparietal junction), the vast majority of existing studies have utilized fMRI paradigms that use non-human or non-interactive stimuli that may limit ecological validity and further fail to examine associations between neural function and real-world outcomes. Collectively, social cognition is a critical factor in psychosis that remains poorly understood. Thus, the proposed study will combine neural, behavioral, and real- world functioning measures to delineate brain-behavior mechanisms of social cognition in FEP. The study will enroll 45 FEP individuals and 45 matched non-clinical controls (NCC) and assess their neural (i.e., fMRI) and behavioral (i.e., validated laboratory-based measures) social cognitive function as well as their real-world social and occupational behavior. Data from this study will allow for an innovative investigation of whether MN dysfunction is associated with social cognitive performance on validated behavioral tasks both across and within FEP and NCC participants (Aim 1), and how these brain-behavior measures of social cognitive performance relate to laboratory-based measures of social and occupational functioning (Aim 2). The current study will also examine the extent to which MN function predicts real-world social and occupational functioning assessed via ecological momentary assessment (Aim 3). This proposal concurrently provides an excellent opportunity to receive mentor-directed, hands-on training in several key areas necessary to refine the candidate’s knowledge and skill-sets. Though the candidate has extensive clinical research experience in FEP and has completed foundational fMRI training, she proposes a training plan focused on three new domains: 1) advanced social- cognitive neuroscience and fMRI task development, 2), linking of fMRI to behavioral constructs of social cognition and functional outcome, and 3) translation of fMRI and behavioral constructs to psychosis. The proposed study coupled with completion of the training plan will effectively launch the candidate toward her long-term goal of an independent career in the translational neuroscience of social-cognitive dysfunction in early psychosis, and will lay the foundation for future, high-impact R01 studies focused on refined identification and targeting of biobehavioral factors influencing social and functional outcomes.

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Aubrey M. Moe其他文献

Specialized, multi‐component care for individuals with first‐episode psychosis: Effects on autonomy, competence and relatedness
针对首发精神病患者的专业化、多成分护理:对自主性、能力和相关性的影响
  • DOI:
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    2
  • 作者:
    N. Breitborde;Jacob G. Pine;Aubrey M. Moe
  • 通讯作者:
    Aubrey M. Moe
Social stress in schizophrenia: Unique contributions to social cognition and social functioning
精神分裂症中的社会应激:对社会认知和社会功能的独特影响
  • DOI:
    10.1016/j.schres.2025.01.015
  • 发表时间:
    2025-02-01
  • 期刊:
  • 影响因子:
    3.500
  • 作者:
    Kathryn C. Kemp;Ivy F. Tso;Stephan F. Taylor;Aubrey M. Moe
  • 通讯作者:
    Aubrey M. Moe
Within-Person Relationship between Attenuated Positive Symptoms and Suicidal Ideation among Individuals at Clinical High Risk for Psychosis.
精神病临床高风险个体中减弱的阳性症状与自杀意念之间的人内关系。
  • DOI:
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    2.8
  • 作者:
    H. Wastler;Henry R Cowan;Sarah A Hamilton;Nancy B Lundin;M. Manges;Aubrey M. Moe;Nicholas J K Breitborde
  • 通讯作者:
    Nicholas J K Breitborde
Improvements in metacognition mediate the effect of metacognitive remediation therapy: A non‐randomized controlled study among individuals with first‐episode psychosis
元认知的改善介导元认知补救治疗的效果:针对首发精神病患者的一项非随机对照研究
  • DOI:
    10.1111/eip.13225
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    2
  • 作者:
    Jacob G. Pine;Aubrey M. Moe;H. Wastler;N. Breitborde
  • 通讯作者:
    N. Breitborde
Social cognition and the course of social functioning in first‐episode psychosis
首发精神病的社会认知和社会功能过程
  • DOI:
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    2
  • 作者:
    Cindy B. Woolverton;Emily Bell;Aubrey M. Moe;Patricia Harrison‐Monroe;Nicholas J K Breitborde
  • 通讯作者:
    Nicholas J K Breitborde

Aubrey M. Moe的其他文献

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