Administrative Core

行政核心

• 批准号: 10747617
• 负责人: Pierre C Dagher
• 金额: $ 15.79万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10747617
• 关键词: Biological Markers; Collaborations; Communication; Communities; Disease Progression; Education; Ensure; Future; Goals; Guidelines; Indiana; Kidney; Kidney Diseases; Lead; Monitor; Pathway interactions; Research; Research Personnel; Resource Development; Resource Sharing; Resources; Services; Testing; Therapeutic Intervention; biomedical resource; imaging science; intravital microscopy; microscopic imaging; molecular imaging; outreach; preclinical study; programs; targeted treatment

Project Summary/Abstract - Administrative Core The overarching goal of the Administrative Core is to lead, manage, and harmonize all aspects of the IU O’Brien U54 National Resource Center (NRC) and ensure that that the IU O’Brien resources are shared nationally. This goal will be accomplished through collaboration with the U24 O’Brien National Coordinating Center (NCC) to: 1) Prioritize external requests from the kidney research community for the efficient utilization of the two IU O’Brien Biomedical Resource Core (BRC) resources consisting of the Intravital Microscopy BRC and the Molecular Imaging BRC; 2) engage in activities to enhance national outreach and impact of the IU O’Brien NRC; 3) educate the community about kidney research; 4) monitor and evaluate emerging advances in imaging science in conjunction with the IU O’Brien Resource Development Core; 5) asses imminent research needs of the kidney research community; 6) organize a broad range of educational programs to provide a pipeline of future kidney researchers, assist early stage investigators, and attract new investigators from outside the kidney research community; and 7) develop pathways that enhance the diversity of the kidney research community. The Administrative Core will serve as the portal for communication and coordination with the O’Brien U24 NCC, other U54 O’Brien NRCs in the consortium, and the kidney research community at large. The IU O’Brien Resource Center will provide a unique and powerful service to the kidney research community. Together, the assets of the two IU O’Brien BRCs and the Resource Development Core coordinated by the Administrative Core will allow investigators in the kidney research community to test and refine key hypotheses as they pertain to a vast array of kidney diseases. Therefore, the proposed research service is significant, because it is expected to aid the kidney research community in identifying critically needed biomarkers of disease progression, optimizing preclinical studies, and developing specific and targeted therapeutic interventions for a wide range of kidney diseases.

项目概要/摘要-行政核心 行政核心的总体目标是领导、管理和协调 IU奥布莱恩U 54国家资源中心（NRC），并确保IU奥布莱恩资源 全国共享。这一目标将通过与U24奥布莱恩国家队的合作来实现。 协调中心（NCC）：1）优先考虑肾脏研究界的外部请求， 有效利用两个IU奥布莱恩生物医学资源核心（BRC）资源，包括 显微镜区域中心和分子成像区域中心; 2）开展活动，加强国家外联， IU奥布莱恩NRC的影响; 3）教育社区有关肾脏研究; 4）监测和评估 与IU奥布莱恩资源开发核心合作的成像科学的新进展; 5） 评估肾脏研究界迫切的研究需求; 6）组织广泛的教育活动， 计划提供未来肾脏研究人员的管道，协助早期研究人员，并吸引新的 来自肾脏研究界以外的研究人员;以及7）开发增强多样性的途径 肾脏研究团体的领导人行政核心将作为沟通和交流的门户， 与奥布莱恩U24 NCC、联盟中的其他U 54奥布莱恩NRC和肾脏研究协调 整个社区。IU奥布莱恩资源中心将为肾脏提供独特而强大的服务。 研究社区。两个IU奥布莱恩BRC和资源开发核心的资产加在一起， 由行政核心协调，将允许肾脏研究界的研究人员测试和 完善关键假设，因为它们与大量肾脏疾病有关。因此，建议的研究 服务是重要的，因为它预计将帮助肾脏研究界在确定关键 需要疾病进展的生物标志物，优化临床前研究，并开发特异性和靶向的 广泛的肾脏疾病的治疗干预。