Biomedical Resource Core

生物医学资源核心

• 批准号: 10747705
• 负责人: Paul A Welling
• 金额: $ 28.59万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10747705
• 关键词: Acceleration; Address; Affect; Animals; Basic Science; Behavior Therapy; Biological Models; Biology; Biometry; Black race; Calorimetry; Chronic Kidney Failure; Clinical Research; Clinical Sciences; Cohort Studies; Collaborations; Collection; Communities; Complex; Consultations; DASH diet; Data; Data Set; Diabetic Nephropathy; Diet; Dietary Assessment; Disease Outcome; Disease Progression; Disparity; Electrolytes; Equipment; Fiber; Food; Fostering; Genetic Models; Germ-Free; Goals; Health Food; Homeostasis; Human; Hypertension; Immunologics; Influentials; Intervention Studies; Investigation; Joints; Kidney; Kidney Diseases; Laboratories; Laboratory Research; Metabolic; Metabolism; Minority; Modeling; Molecular; Mus; Nutritional; Obesity; Obesity Epidemic; Observational Study; Pathway Analysis; Periodicals; Persons; Phenotype; Physiology; Pilot Projects; Population; Population Heterogeneity; Potassium; Potassium Deficiency; Prevention; Procedures; Process; Protocols documentation; Quality Control; Race; Research; Research Design; Research Personnel; Research Project Grants; Resources; Role; Services; Sodium; Specimen; Stress; Study models; Technology; Training; Trans Fats; Translational Research; Translations; Unhealthy Diet; Validation; biobank; biomedical resource; burden of illness; carbohydrate metabolism; caucasian American; design; dietary; disease disparity; disorder risk; epidemiology study; ethnic minority population; experience; experimental study; feeding; follow-up; food insecurity; fundamental research; gene discovery; health disparity; health equity; health equity promotion; human model; humanized mouse; innovation; lipid metabolism; marginalized community; member; microbiome; mouse model; pre-clinical research; racial disparity; racial minority population; saturated fat; social; social health determinants; social stress; social stressor; socioeconomic disparity; socioeconomics; stressor; sugar; tool; translational pipeline; translational study

ABSTRACT The Biomedical Resource Core (BRC) of the Johns Hopkins O’Brien Center to Advance Kidney Health Equity will provide an innovative portfolio of research services, resources, and tools for investigators to understand and ameliorate disparities in kidney disease, towards ultimately achieving kidney health equity. With a focus on dietary and social stresses that drive kidney health disparities, the BRC is uniquely designed to address this fundamental challenge with a broad impact, advancing kidney research nationally. A Clinical Science Dietary and Social Stressor Laboratory (C-DSSL) directed by Dr. Lawrence Appel, and a Basic Science Dietary and Social Stressor Laboratory (B-DSSL), directed by Dr. Paul Welling provide expert consultation, proven protocols, training, access to materials and equipment; and will execute pilot studies or larger research projects. A joint consultation service, and a deliberate team approach meld the two laboratories, and create an innovative bidirectional pipeline that maximizes translation. The C-DSSL will provide the following services : 1) clinical study design; 2) dietary assessment; 3) access to numerous large cohort studies, with racially and socioeconomically diverse populations, deep phenotyping and collection of dietary data, stored biospecimens, and long follow-up periods; 4) feeding studies modeled on the Dietary Approaches to Stop Hypertension trials; 5) behavioral intervention studies; 6) translational studies in the community; 7) use of publicly available datasets; and 8) biostatistical support. The B-DSSL will provide investigators with comprehensive services and resources for preclinical research to determine the mechanistic underpinnings of human health disparity stressors, using mice as a model system; services will include: 1) study design; 2) humanized mouse diet protocols; 3) a comprehensive mouse kidney phenotyping core for exploring stress mechanisms from whole animal physiology to molecular mechanism; 4) a lipid and carbohydrate metabolism phenotyping core, equipped with state-of-the-art metabolic cages for calorimetry; 5) a core for studying immunological manifestations of dietary and social stressors in the kidney; 6) a microbiome core with a state-of-the-art germ- free facility; and 7) a mouse biobank of dietary and social stress models. All shared services and resources will undergo strict quality control, validation, and periodic review of demand and impact. In addition to the services provided by the laboratories and their integrated approach, the BRC will foster training and capacity building to maximize entry of early-stage investigators from diverse fields new to kidney health equity research. The BRC is committed to collaborating with the consortium broadly, and to freely sharing its specialized resources.

摘要 约翰霍普金斯奥布莱恩中心的生物医学资源核心（BRC），以促进肾脏健康公平 将为研究人员提供创新的研究服务、资源和工具组合， 并改善肾脏疾病的差异，最终实现肾脏健康公平。重点是 饮食和社会压力导致肾脏健康差异，BRC是专门为解决这一问题而设计的 具有广泛影响的根本挑战，推动全国肾脏研究。临床科学饮食 和社会压力实验室（C-DSSL）由劳伦斯阿佩尔博士指导，和基础科学饮食和 社会压力源实验室（B-DSSL），由保罗·威林博士指导，提供专家咨询，证明 协议、培训、获得材料和设备;并将进行试点研究或更大规模的研究 项目联合咨询服务和深思熟虑的团队方法将两个实验室融合在一起， 创新的双向管道，最大限度地提高翻译。C-DSSL将提供以下服务：1） 临床研究设计; 2）饮食评估; 3）获得大量的大型队列研究， 社会经济多样化的人群，深入的表型分析和饮食数据收集，储存的生物标本， 4）以饮食方法阻止高血压试验为模型的喂养研究; 5)行为干预研究; 6）社区转化研究; 7）使用公开可用的 数据集;以及 8)生物统计学支持。B-DSSL将为研究者提供全面的服务， 用于临床前研究的资源，以确定人类健康差异的机制基础 应激源，使用小鼠作为模型系统;服务将包括：1）研究设计; 2）人源化小鼠饮食 方案; 3）一个全面的小鼠肾脏表型核心，用于从整体上探索应激机制 动物生理学到分子机制; 4）脂质和碳水化合物代谢表型核心， 配备最先进的代谢笼进行热量测定; 5）研究免疫学的核心 肾脏中饮食和社会压力的表现; 6）具有最先进细菌的微生物组核心- 免费设施;和7）饮食和社会压力模型的小鼠生物库。所有共享的服务和资源 将经过严格的质量控制，验证，并定期审查需求和影响。除了有 通过实验室提供的服务及其综合方法，布拉迪斯拉发区域中心将促进培训和能力建设， 建设，以最大限度地进入早期阶段的研究人员从不同领域的新肾脏健康公平研究。 BRC致力于与该联盟广泛合作，并自由分享其专业知识。 资源