The Environmental Factors in FEtal to Childhood Trajectories Cohort

胎儿到童年轨迹队列中的环境因素

• 批准号: 10746037
• 负责人: Burton Rochelson
• 金额: $ 244.89万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10746037
• 关键词: Address; Adult; Advisory Committees; Age; Biological Markers; Birth; Body Composition; Body mass index; Caregivers; Chemicals; Child; Child Development; Child Health; Childhood; Clinical; Cohort Effect; Collection; Communication; Communities; Conceptions; Data; Discipline of obstetrics; Enrollment; Ensure; Environment; Environmental Exposure; Environmental Risk Factor; Environmental Science; Epidemiology; Ethnic Origin; Ethnic Population; Exposure to; Family; Financial Hardship; Goals; Growth; Health system; Integrated Health Care Systems; Length; Life; Low income; Measures; Minority Groups; Modeling; Morbidity - disease rate; New York; Obesity; Outcome; Overweight; Parents; Participant; Pediatric cohort; Persons; Physiological; Play; Population; Positioning Attribute; Practice Management; Pregnancy; Process; Protocols documentation; Race; Research; Risk Factors; Role; Science; Scientist; Social support; Stressful Event; Surveys; Technology; Testing; Training; United States; Weight; cardiometabolism; career; chatbot; child bearing; cohort; community based participatory research; community engagement; data management; early childhood; early life exposure; experience; fetal; in utero; infancy; innovation; intergenerational; maternal stress; minority children; minority communities; mortality; next generation; obesity in children; obesity prevention; obesity risk; operation; patient engagement; patient population; pediatric health outcomes; phthalates; pregnant; prenatal exposure; programs; prospective; psychosocial; racial minority population; recruit; research study; social; social health determinants; social vulnerability; socioeconomic diversity; structural determinants; transmission process

PROJECT SUMMARY / ABSTRACT The Environmental influences on Child Health Outcomes (ECHO) Pediatric Cohorts program launched in 2016, bringing together more than 30 extant cohorts to investigate the roles of a broad range of early exposures on five key child health outcomes. ECHO is now expanding to include new cohorts starting in pregnancy. We propose to recruit the Environmental Factors in FEtal to Childhood Trajectories EFFECT cohort to participate in the ECHO program. EFFECT will be a prospective birth cohort of 2,800 pregnant people, their partners, and their children recruited in southern New York State over 7 years. The scientific premise of our cohort is that social determinants of health (SDoH) impacting both parents before a child’s birth play a significant role in the development of child obesity. Our Specific Aims are: Aim 1: Test the hypothesis that in-utero chemical and maternal psychosocial exposures during pregnancy interact to create differential childhood growth trajectories (growth latency and growth spurts) from birth to age 5. We will leverage survey and biomarker data collected under the ECHO core protocol to model the impact of concurrent in utero exposure to phthalates and maternal stress on childhood growth trajectories. Aim 2: Test the hypothesis that early life exposure to adverse social determinants of health (SDoH) are associated with higher rates of child obesity and that this association varies by racial/ethnic background. We will leverage specialized exposure data (psychosocial environment) and specialized outcome data (obesity) to test the hypothesis that exposure to parental material hardships and psychosocial vulnerabilities is associated with higher rates of child obesity, particularly for children from minority groups. Aim 3: Recruit and retain a robust, diverse cohort of 2,800 families and implement the ECHO protocol with high fidelity. We will partner with our extremely diverse patient population and leverage innovative participant-centric technological support as well as committed community engagement to achieve this Aim. Exploratory Aim 4: To measure the direct and interactive effects of preconception physiologic and psychosocial exposures on child weight outcomes. We will measure the direct and interactive effects of pre- conception adiposity and caregiver receipt of social support on early life measures of child obesity risk. Our proposed cohort and study team are perfectly positioned to meet the current needs of the ECHO program: 1) to address solution-oriented scientific questions of high priority; 2) to increase the number of enrolled pregnant participants; 3) to facilitate the enrollment of the non-gestational parent; 4) to facilitate collection of preconception data; 5) to increase the racial, ethnic, and socioeconomic diversity of the ECHO cohort; and 6) to increase diversity in race, ethnicity, career stage, and professional background of the research workforce.

项目总结/摘要 环境对儿童健康结果的影响（ECHO）儿科队列计划于2016年启动， 汇集了30多个现存的队列，以调查广泛的早期暴露对 五个关键的儿童健康成果。ECHO目前正在扩大范围，以包括从怀孕开始的新队列。我们 建议招募胎儿至儿童轨迹效应队列中的环境因素参与 ECHO计划。EFFECT将是一个前瞻性的出生队列，包括2,800名孕妇、她们的伴侣和她们的孩子。 在纽约州南部招募的儿童超过7年。我们这一组的科学前提是， 健康的决定因素（SDoH）在孩子出生前影响父母双方在孩子出生后的生活中发挥着重要作用。 儿童肥胖症的发展。我们的具体目标是： 目的1：检验以下假设： 怀孕相互作用，创造不同的儿童生长轨迹（生长潜伏期和生长 从出生到5岁。我们将利用在ECHO核心下收集的调查和生物标志物数据 模拟宫内邻苯二甲酸酯暴露和母亲压力对儿童影响的方案 成长轨迹 目标2：检验以下假设：早年接触不利的健康社会决定因素（SDoH） 与儿童肥胖率较高相关，并且这种关联因种族/民族而异 背景我们将利用专门的暴露数据（心理社会环境）和专门的结果 数据（肥胖）来检验假设，暴露于父母的物质困难和心理社会脆弱性 与儿童肥胖率较高有关，特别是少数群体的儿童。 目标3：招募和保留一个由2，800个家庭组成的强大的多样化队列，并实施ECHO协议 高保真度。我们将与极其多样化的患者群体合作， 以参与者为中心的技术支持，以及致力于社区参与，以实现这一目标。 探索性目标4：测量孕前生理和心理因素的直接和交互作用， 心理社会暴露对儿童体重的影响。我们将测量预处理的直接和交互影响， 怀孕肥胖和照顾者接受的社会支持对儿童肥胖风险的早期生活措施。 我们建议的队列和研究团队完全能够满足ECHO计划的当前需求： 1)解决高度优先的以解决问题为导向的科学问题; 2）增加怀孕妇女的入学人数， 参与者; 3）促进非妊娠父母的登记; 4）促进收集孕前资料 数据; 5）增加ECHO队列的种族，民族和社会经济多样性; 6）增加 研究人员的种族、民族、职业阶段和专业背景的多样性。