The Environmental Factors in FEtal to Childhood Trajectories Cohort

胎儿到童年轨迹队列中的环境因素

• 批准号: 10746037
• 负责人: Burton Rochelson
• 金额: $ 244.89万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10746037
• 关键词: Address; Adult; Advisory Committees; Age; Biological Markers; Birth; Body Composition; Body mass index; Caregivers; Chemicals; Child; Child Development; Child Health; Childhood; Clinical; Cohort Effect; Collection; Communication; Communities; Conceptions; Data; Discipline of obstetrics; Enrollment; Ensure; Environment; Environmental Exposure; Environmental Risk Factor; Environmental Science; Epidemiology; Ethnic Origin; Ethnic Population; Exposure to; Family; Financial Hardship; Goals; Growth; Health system; Integrated Health Care Systems; Length; Life; Low income; Measures; Minority Groups; Modeling; Morbidity - disease rate; New York; Obesity; Outcome; Overweight; Parents; Participant; Pediatric cohort; Persons; Physiological; Play; Population; Positioning Attribute; Practice Management; Pregnancy; Process; Protocols documentation; Race; Research; Risk Factors; Role; Science; Scientist; Social support; Stressful Event; Surveys; Technology; Testing; Training; United States; Weight; cardiometabolism; career; chatbot; child bearing; cohort; community based participatory research; community engagement; data management; early childhood; early life exposure; experience; fetal; in utero; infancy; innovation; intergenerational; maternal stress; minority children; minority communities; mortality; next generation; obesity in children; obesity prevention; obesity risk; operation; patient engagement; patient population; pediatric health outcomes; phthalates; pregnant; prenatal exposure; programs; prospective; psychosocial; racial minority population; recruit; research study; social; social health determinants; social vulnerability; socioeconomic diversity; structural determinants; transmission process

PROJECT SUMMARY / ABSTRACT The Environmental influences on Child Health Outcomes (ECHO) Pediatric Cohorts program launched in 2016, bringing together more than 30 extant cohorts to investigate the roles of a broad range of early exposures on five key child health outcomes. ECHO is now expanding to include new cohorts starting in pregnancy. We propose to recruit the Environmental Factors in FEtal to Childhood Trajectories EFFECT cohort to participate in the ECHO program. EFFECT will be a prospective birth cohort of 2,800 pregnant people, their partners, and their children recruited in southern New York State over 7 years. The scientific premise of our cohort is that social determinants of health (SDoH) impacting both parents before a child’s birth play a significant role in the development of child obesity. Our Specific Aims are: Aim 1: Test the hypothesis that in-utero chemical and maternal psychosocial exposures during pregnancy interact to create differential childhood growth trajectories (growth latency and growth spurts) from birth to age 5. We will leverage survey and biomarker data collected under the ECHO core protocol to model the impact of concurrent in utero exposure to phthalates and maternal stress on childhood growth trajectories. Aim 2: Test the hypothesis that early life exposure to adverse social determinants of health (SDoH) are associated with higher rates of child obesity and that this association varies by racial/ethnic background. We will leverage specialized exposure data (psychosocial environment) and specialized outcome data (obesity) to test the hypothesis that exposure to parental material hardships and psychosocial vulnerabilities is associated with higher rates of child obesity, particularly for children from minority groups. Aim 3: Recruit and retain a robust, diverse cohort of 2,800 families and implement the ECHO protocol with high fidelity. We will partner with our extremely diverse patient population and leverage innovative participant-centric technological support as well as committed community engagement to achieve this Aim. Exploratory Aim 4: To measure the direct and interactive effects of preconception physiologic and psychosocial exposures on child weight outcomes. We will measure the direct and interactive effects of pre- conception adiposity and caregiver receipt of social support on early life measures of child obesity risk. Our proposed cohort and study team are perfectly positioned to meet the current needs of the ECHO program: 1) to address solution-oriented scientific questions of high priority; 2) to increase the number of enrolled pregnant participants; 3) to facilitate the enrollment of the non-gestational parent; 4) to facilitate collection of preconception data; 5) to increase the racial, ethnic, and socioeconomic diversity of the ECHO cohort; and 6) to increase diversity in race, ethnicity, career stage, and professional background of the research workforce.

项目概要/摘要 环境对儿童健康结果的影响 (ECHO) 儿科队列计划于 2016 年启动， 汇集了 30 多个现有队列来研究各种早期暴露的作用 五项关键的儿童健康成果。 ECHO 目前正在扩大范围，纳入从怀孕开始的新人群。我们 建议招募 FEtal 中的环境因素对童年轨迹影响队列来参与 回声计划。 EFFECT 将是一个由 2,800 名孕妇及其伴侣及其伴侣组成的前瞻性出生队列 在纽约州南部招募的儿童已超过 7 年。我们队列的科学前提是社会 在孩子出生前影响父母双方的健康决定因素 (SDoH) 在孩子出生前发挥着重要作用 儿童肥胖的发展。我们的具体目标是： 目标 1：检验以下假设：子宫内化学物质和母亲社会心理暴露 怀孕相互作用产生不同的儿童生长轨迹（生长潜伏期和生长 从出生到 5 岁。我们将利用 ECHO 核心下收集的调查和生物标志物数据 模拟子宫内同时接触邻苯二甲酸盐和母亲压力对儿童影响的方案 成长轨迹。 目标 2：检验以下假设：生命早期接触不利的健康社会决定因素 (SDoH) 与较高的儿童肥胖率相关，并且这种关联因种族/民族而异 背景。我们将利用专门的暴露数据（心理社会环境）和专门的结果 数据（肥胖）来检验以下假设：父母的物质困难和社会心理脆弱性 与较高的儿童肥胖率相关，特别是对于少数群体的儿童。 目标 3：招募并留住 2,800 个家庭的强大、多元化群体并实施 ECHO 协议 具有高保真度。我们将与极其多样化的患者群体合作，并利用创新 以参与者为中心的技术支持以及致力于实现这一目标的社区参与。 探索性目标 4：测量孕前生理和心理因素的直接和交互影响 社会心理暴露对儿童体重结果的影响。我们将衡量预演的直接和互动效果 受孕肥胖和照顾者在早期生命测量儿童肥胖风险方面获得社会支持。 我们提议的队列和研究团队完全可以满足 ECHO 项目当前的需求： 1）解决以解决方案为导向的高度优先的科学问题； 2）增加怀孕登记人数 参与者； 3) 便利非妊娠父母的注册； 4）便于收集先入为主的信息 数据; 5) 增加 ECHO 人群的种族、民族和社会经济多样性； 6) 增加 研究人员的种族、民族、职业阶段和专业背景的多样性。