Imaging Cerebral Small Vessels in Vascular Cognitive Impairment and Dementia (VCID)
血管性认知障碍和痴呆 (VCID) 中的脑小血管成像
基本信息
- 批准号:10745164
- 负责人:
- 金额:$ 248.77万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAccelerationAfrican AmericanAgeAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAsianAsian AmericansAtrophicBehavioralBloodBlood VesselsBlood capillariesBrainCaucasiansCerebral small vessel diseaseCerebrumClinicalCognitiveDataDementiaDevelopmentDiffusionEarly InterventionEnrollmentEvaluationGoalsGuidelinesHeadImageImage AnalysisImaging DeviceImaging technologyKnowledgeLacunar InfarctionsLatinxLesionLongitudinal cohortLos AngelesMagnetic Resonance ImagingMapsMediatingMorphologyMotionNeuropsychologyParticipantPathway AnalysisPerforating ArteryPerfusionPhysicsPhysiologicalPopulationPreventionProtocols documentationPublic HealthResearchResearch PriorityResolutionResourcesRiskSpeedStrokeSurrogate MarkersTechniquesTestingThree-dimensional analysisTrainingVisitVisualizationagedanalysis pipelinearterial spin labelingarteriolebehavioral phenotypingbiomedical imagingcerebral microbleedscerebrovascularclinical diagnosiscohortdeep learning algorithmdensitydisease phenotypeexecutive functionhealth disparityhigh riskimaging biomarkerimprovedin vivo imaginglongitudinal analysismild cognitive impairmentmixed dementiamulti-ethnicmultidisciplinarynovelpotential biomarkerracial diversityrecruitsymposiumvascular cognitive impairment and dementiavenulewhite matter
项目摘要
Project Summary/Abstract
Vascular contributions to cognitive impairment and dementia (VCID) is becoming increasingly recognized as
an important cause of dementia. Cerebral small vessel disease (cSVD) is the most common vascular cause of
dementia, a major contributor to mixed dementia, and the cause of about one fifth of all strokes worldwide.
However, the underlying mechanisms of cSVD remain poorly understood. The large knowledge gap in cSVD is
partly because cerebral small vessels, including arterioles, capillaries and venules, are inaccessible to existing
in vivo imaging technologies. During the past few years, our group has spearheaded the development of a new
high-resolution black-blood MRI technique for the visualization, segmentation and quantification of cerebral
small vessels including lenticulostriate and superficial perforating arteries and venules. This technique offers
an isotropic ~0.5mm spatial resolution, adequate flow suppression for small vessels due to the long echo train,
and near whole-brain coverage in ~10min at clinical field strength of 3T. We further developed a
comprehensive 3D analysis pipeline for quantifying the morphology and density of cerebral small vessels with
sizes on the order of a few hundred microns. In addition, we have a longstanding track record in developing
and applying arterial spin labeling (ASL) techniques for quantifying microvascular perfusion – a key
physiological parameter and potential biomarker for cSVD. Our preliminary data demonstrated expected
changes in small vessel morphology and density as well as microvascular perfusion with aging, vascular risks
and mild cognitive impairment (MCI), supporting the use of metrics of small vessel morphology/density and
microvascular perfusion as imaging markers of cSVD and VCID. The primary goals of this project are to further
optimize the acquisition protocol and analysis pipeline for mapping and quantifying cerebral small vessels
using black-blood and ASL MRI at 3T, and to systematically evaluate metrics of small vessel
morphology/density and perfusion as imaging biomarkers of VCID in a multiethnic longitudinal cohort of 200
subjects that are enriched for small vessel VCID. In particular, our study will enroll a cohort of 50 Asian
Americans who are among the fastest growing populations in the US but are highly underrepresented in ADRD
research. This project is expected to result in a powerful suite of imaging tools for comprehensive
characterization of the morphology and function of cerebral small vessels, as well as to fill in the important gap
in health disparities of Asian Americans in ADRD research.
项目概要/摘要
人们越来越认识到血管对认知障碍和痴呆 (VCID) 的影响
痴呆的一个重要原因。脑小血管病(cSVD)是最常见的血管疾病
痴呆症是混合性痴呆症的主要原因,也是全世界约五分之一中风的原因。
然而,cSVD 的潜在机制仍然知之甚少。 CSVD 中巨大的知识差距是
部分原因是现有的脑小血管(包括小动脉、毛细血管和小静脉)无法进入
体内成像技术。在过去的几年里,我们集团率先开发了一种新的
高分辨率黑血 MRI 技术,用于大脑的可视化、分割和量化
小血管包括豆纹和浅表穿支动脉和小静脉。该技术提供了
各向同性 ~0.5mm 空间分辨率,由于长回波序列,对小血管有足够的流量抑制,
在 3T 临床场强下,约 10 分钟即可实现近乎全脑覆盖。我们进一步开发了
全面的 3D 分析流程,用于量化脑小血管的形态和密度
尺寸在几百微米的量级。此外,我们在开发方面拥有长期的记录
并应用动脉自旋标记 (ASL) 技术来量化微血管灌注——关键
cSVD 的生理参数和潜在生物标志物。我们的初步数据表明预期
小血管形态和密度的变化以及微血管灌注随衰老、血管风险的变化
和轻度认知障碍(MCI),支持使用小血管形态/密度和
微血管灌注作为 cSVD 和 VCID 的成像标志物。该项目的主要目标是进一步
优化用于绘制和量化脑小血管的采集协议和分析管道
使用 3T 黑血和 ASL MRI,系统地评估小血管的指标
在 200 名多种族纵向队列中,将形态/密度和灌注作为 VCID 的成像生物标志物
丰富了小血管 VCID 的受试者。特别是,我们的研究将招募 50 名亚洲人
属于美国人口增长最快但在 ADRD 中代表性严重不足的美国人
研究。该项目预计将产生一套强大的成像工具,用于全面的
表征脑小血管的形态和功能,并填补重要空白
ADRD 研究中亚裔美国人的健康差异。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Xuejuan Jiang其他文献
Xuejuan Jiang的其他文献
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{{ truncateString('Xuejuan Jiang', 18)}}的其他基金
Intrauterine exposure to tobacco smoke, DNA methylation, and vision disorders in preschool children
学龄前儿童宫内烟草烟雾暴露、DNA 甲基化和视力障碍
- 批准号:
10669723 - 财政年份:2019
- 资助金额:
$ 248.77万 - 项目类别:
Intrauterine exposure to tobacco smoke, DNA methylation, and vision disorders in preschool children
学龄前儿童宫内烟草烟雾暴露、DNA 甲基化和视力障碍
- 批准号:
10000978 - 财政年份:2019
- 资助金额:
$ 248.77万 - 项目类别:
Intrauterine exposure to tobacco smoke, DNA methylation, and vision disorders in preschool children
学龄前儿童宫内烟草烟雾暴露、DNA 甲基化和视力障碍
- 批准号:
10220040 - 财政年份:2019
- 资助金额:
$ 248.77万 - 项目类别:
Intrauterine exposure to tobacco smoke, DNA methylation, and vision disorders in preschool children
学龄前儿童宫内烟草烟雾暴露、DNA 甲基化和视力障碍
- 批准号:
9803632 - 财政年份:2019
- 资助金额:
$ 248.77万 - 项目类别:
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