Imaging Cerebral Small Vessels in Vascular Cognitive Impairment and Dementia (VCID)

血管性认知障碍和痴呆 (VCID) 中的脑小血管成像

• 批准号: 10745164
• 负责人: Xuejuan Jiang
• 金额: $ 248.77万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745164
• 关键词: 3-Dimensional; Acceleration; African American; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Asian; Asian Americans; Atrophic; Behavioral; Blood; Blood Vessels; Blood capillaries; Brain; Caucasians; Cerebral small vessel disease; Cerebrum; Clinical; Cognitive; Data; Dementia; Development; Diffusion; Early Intervention; Enrollment; Evaluation; Goals; Guidelines; Head; Image; Image Analysis; Imaging Device; Imaging technology; Knowledge; Lacunar Infarctions; Latinx; Lesion; Longitudinal cohort; Los Angeles; Magnetic Resonance Imaging; Maps; Mediating; Morphology; Motion; Neuropsychology; Participant; Pathway Analysis; Perforating Artery; Perfusion; Physics; Physiological; Population; Prevention; Protocols documentation; Public Health; Research; Research Priority; Resolution; Resources; Risk; Speed; Stroke; Surrogate Markers; Techniques; Testing; Three-dimensional analysis; Training; Visit; Visualization; aged; analysis pipeline; arterial spin labeling; arteriole; behavioral phenotyping; biomedical imaging; cerebral microbleeds; cerebrovascular; clinical diagnosis; cohort; deep learning algorithm; density; disease phenotype; executive function; health disparity; high risk; imaging biomarker; improved; in vivo imaging; longitudinal analysis; mild cognitive impairment; mixed dementia; multi-ethnic; multidisciplinary; novel; potential biomarker; racial diversity; recruit; symposium; vascular cognitive impairment and dementia; venule; white matter

Project Summary/Abstract Vascular contributions to cognitive impairment and dementia (VCID) is becoming increasingly recognized as an important cause of dementia. Cerebral small vessel disease (cSVD) is the most common vascular cause of dementia, a major contributor to mixed dementia, and the cause of about one fifth of all strokes worldwide. However, the underlying mechanisms of cSVD remain poorly understood. The large knowledge gap in cSVD is partly because cerebral small vessels, including arterioles, capillaries and venules, are inaccessible to existing in vivo imaging technologies. During the past few years, our group has spearheaded the development of a new high-resolution black-blood MRI technique for the visualization, segmentation and quantification of cerebral small vessels including lenticulostriate and superficial perforating arteries and venules. This technique offers an isotropic ~0.5mm spatial resolution, adequate flow suppression for small vessels due to the long echo train, and near whole-brain coverage in ~10min at clinical field strength of 3T. We further developed a comprehensive 3D analysis pipeline for quantifying the morphology and density of cerebral small vessels with sizes on the order of a few hundred microns. In addition, we have a longstanding track record in developing and applying arterial spin labeling (ASL) techniques for quantifying microvascular perfusion – a key physiological parameter and potential biomarker for cSVD. Our preliminary data demonstrated expected changes in small vessel morphology and density as well as microvascular perfusion with aging, vascular risks and mild cognitive impairment (MCI), supporting the use of metrics of small vessel morphology/density and microvascular perfusion as imaging markers of cSVD and VCID. The primary goals of this project are to further optimize the acquisition protocol and analysis pipeline for mapping and quantifying cerebral small vessels using black-blood and ASL MRI at 3T, and to systematically evaluate metrics of small vessel morphology/density and perfusion as imaging biomarkers of VCID in a multiethnic longitudinal cohort of 200 subjects that are enriched for small vessel VCID. In particular, our study will enroll a cohort of 50 Asian Americans who are among the fastest growing populations in the US but are highly underrepresented in ADRD research. This project is expected to result in a powerful suite of imaging tools for comprehensive characterization of the morphology and function of cerebral small vessels, as well as to fill in the important gap in health disparities of Asian Americans in ADRD research.

项目总结/摘要 血管对认知障碍和痴呆（VCID）的贡献越来越被认为是 痴呆症的一个重要原因脑小血管病（cSVD）是脑血管病最常见的血管原因。 痴呆症是混合型痴呆症的主要原因，也是全球约五分之一中风的原因。 然而，cSVD的潜在机制仍然知之甚少。cSVD中的巨大知识缺口是 部分原因是大脑的小血管，包括小动脉、毛细血管和小静脉， 活体成像技术。在过去的几年里，我们集团率先开发了一种新的 高分辨率黑血磁共振成像技术用于脑血管成像的可视化、分割和定量 小血管包括横纹动脉和浅穿动脉和小静脉。这项技术提供 各向同性~ 0.5 mm的空间分辨率，由于长回波链，对小血管有足够的血流抑制， 在临床场强3 T下，10 min内可达到近全脑覆盖。我们进一步开发了一个 用于量化脑小血管形态和密度的全面3D分析管道， 尺寸在几百微米的量级。此外，我们在开发 应用动脉自旋标记（ASL）技术定量微血管灌注-一个关键 cSVD的生理参数和潜在生物标志物。我们的初步数据显示， 小血管形态和密度以及微血管灌注随年龄的变化，血管风险 和轻度认知障碍（MCI），支持使用小血管形态/密度指标， 微血管灌注作为cSVD和VCID的成像标志物。该项目的主要目标是进一步 优化采集协议和分析管道，以标测和量化脑小血管 使用3 T黑血和ASL MRI，系统评价小血管的指标 形态/密度和灌注作为VCID的成像生物标志物，在200人的多种族纵向队列中 富含小血管VCID的受试者。特别是，我们的研究将招募50名亚洲人， 美国人是美国人口增长最快的国家之一，但在ADRD中的代表性严重不足 research.该项目预计将产生一套功能强大的成像工具， 表征脑小血管的形态和功能，以及填补重要的空白 亚裔美国人在ADRD研究中的健康差异。