Imaging Cerebral Small Vessels in Vascular Cognitive Impairment and Dementia (VCID)
血管性认知障碍和痴呆 (VCID) 中的脑小血管成像
基本信息
- 批准号:10745164
- 负责人:
- 金额:$ 248.77万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAccelerationAfrican AmericanAgeAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAsianAsian AmericansAtrophicBehavioralBloodBlood VesselsBlood capillariesBrainCaucasiansCerebral small vessel diseaseCerebrumClinicalCognitiveDataDementiaDevelopmentDiffusionEarly InterventionEnrollmentEvaluationGoalsGuidelinesHeadImageImage AnalysisImaging DeviceImaging technologyKnowledgeLacunar InfarctionsLatinxLesionLongitudinal cohortLos AngelesMagnetic Resonance ImagingMapsMediatingMorphologyMotionNeuropsychologyParticipantPathway AnalysisPerforating ArteryPerfusionPhysicsPhysiologicalPopulationPreventionProtocols documentationPublic HealthResearchResearch PriorityResolutionResourcesRiskSpeedStrokeSurrogate MarkersTechniquesTestingThree-dimensional analysisTrainingVisitVisualizationagedanalysis pipelinearterial spin labelingarteriolebehavioral phenotypingbiomedical imagingcerebral microbleedscerebrovascularclinical diagnosiscohortdeep learning algorithmdensitydisease phenotypeexecutive functionhealth disparityhigh riskimaging biomarkerimprovedin vivo imaginglongitudinal analysismild cognitive impairmentmixed dementiamulti-ethnicmultidisciplinarynovelpotential biomarkerracial diversityrecruitsymposiumvascular cognitive impairment and dementiavenulewhite matter
项目摘要
Project Summary/Abstract
Vascular contributions to cognitive impairment and dementia (VCID) is becoming increasingly recognized as
an important cause of dementia. Cerebral small vessel disease (cSVD) is the most common vascular cause of
dementia, a major contributor to mixed dementia, and the cause of about one fifth of all strokes worldwide.
However, the underlying mechanisms of cSVD remain poorly understood. The large knowledge gap in cSVD is
partly because cerebral small vessels, including arterioles, capillaries and venules, are inaccessible to existing
in vivo imaging technologies. During the past few years, our group has spearheaded the development of a new
high-resolution black-blood MRI technique for the visualization, segmentation and quantification of cerebral
small vessels including lenticulostriate and superficial perforating arteries and venules. This technique offers
an isotropic ~0.5mm spatial resolution, adequate flow suppression for small vessels due to the long echo train,
and near whole-brain coverage in ~10min at clinical field strength of 3T. We further developed a
comprehensive 3D analysis pipeline for quantifying the morphology and density of cerebral small vessels with
sizes on the order of a few hundred microns. In addition, we have a longstanding track record in developing
and applying arterial spin labeling (ASL) techniques for quantifying microvascular perfusion – a key
physiological parameter and potential biomarker for cSVD. Our preliminary data demonstrated expected
changes in small vessel morphology and density as well as microvascular perfusion with aging, vascular risks
and mild cognitive impairment (MCI), supporting the use of metrics of small vessel morphology/density and
microvascular perfusion as imaging markers of cSVD and VCID. The primary goals of this project are to further
optimize the acquisition protocol and analysis pipeline for mapping and quantifying cerebral small vessels
using black-blood and ASL MRI at 3T, and to systematically evaluate metrics of small vessel
morphology/density and perfusion as imaging biomarkers of VCID in a multiethnic longitudinal cohort of 200
subjects that are enriched for small vessel VCID. In particular, our study will enroll a cohort of 50 Asian
Americans who are among the fastest growing populations in the US but are highly underrepresented in ADRD
research. This project is expected to result in a powerful suite of imaging tools for comprehensive
characterization of the morphology and function of cerebral small vessels, as well as to fill in the important gap
in health disparities of Asian Americans in ADRD research.
项目总结/摘要
血管对认知障碍和痴呆(VCID)的贡献越来越被认为是
痴呆症的一个重要原因脑小血管病(cSVD)是脑血管病最常见的血管原因。
痴呆症是混合型痴呆症的主要原因,也是全球约五分之一中风的原因。
然而,cSVD的潜在机制仍然知之甚少。cSVD中的巨大知识缺口是
部分原因是大脑的小血管,包括小动脉、毛细血管和小静脉,
活体成像技术。在过去的几年里,我们集团率先开发了一种新的
高分辨率黑血磁共振成像技术用于脑血管成像的可视化、分割和定量
小血管包括横纹动脉和浅穿动脉和小静脉。这项技术提供
各向同性~ 0.5 mm的空间分辨率,由于长回波链,对小血管有足够的血流抑制,
在临床场强3 T下,10 min内可达到近全脑覆盖。我们进一步开发了一个
用于量化脑小血管形态和密度的全面3D分析管道,
尺寸在几百微米的量级。此外,我们在开发
应用动脉自旋标记(ASL)技术定量微血管灌注-一个关键
cSVD的生理参数和潜在生物标志物。我们的初步数据显示,
小血管形态和密度以及微血管灌注随年龄的变化,血管风险
和轻度认知障碍(MCI),支持使用小血管形态/密度指标,
微血管灌注作为cSVD和VCID的成像标志物。该项目的主要目标是进一步
优化采集协议和分析管道,以标测和量化脑小血管
使用3 T黑血和ASL MRI,系统评价小血管的指标
形态/密度和灌注作为VCID的成像生物标志物,在200人的多种族纵向队列中
富含小血管VCID的受试者。特别是,我们的研究将招募50名亚洲人,
美国人是美国人口增长最快的国家之一,但在ADRD中的代表性严重不足
research.该项目预计将产生一套功能强大的成像工具,
表征脑小血管的形态和功能,以及填补重要的空白
亚裔美国人在ADRD研究中的健康差异。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Xuejuan Jiang其他文献
Xuejuan Jiang的其他文献
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{{ truncateString('Xuejuan Jiang', 18)}}的其他基金
Intrauterine exposure to tobacco smoke, DNA methylation, and vision disorders in preschool children
学龄前儿童宫内烟草烟雾暴露、DNA 甲基化和视力障碍
- 批准号:
10669723 - 财政年份:2019
- 资助金额:
$ 248.77万 - 项目类别:
Intrauterine exposure to tobacco smoke, DNA methylation, and vision disorders in preschool children
学龄前儿童宫内烟草烟雾暴露、DNA 甲基化和视力障碍
- 批准号:
10000978 - 财政年份:2019
- 资助金额:
$ 248.77万 - 项目类别:
Intrauterine exposure to tobacco smoke, DNA methylation, and vision disorders in preschool children
学龄前儿童宫内烟草烟雾暴露、DNA 甲基化和视力障碍
- 批准号:
10220040 - 财政年份:2019
- 资助金额:
$ 248.77万 - 项目类别:
Intrauterine exposure to tobacco smoke, DNA methylation, and vision disorders in preschool children
学龄前儿童宫内烟草烟雾暴露、DNA 甲基化和视力障碍
- 批准号:
9803632 - 财政年份:2019
- 资助金额:
$ 248.77万 - 项目类别:
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