Imaging Cerebral Small Vessels in Vascular Cognitive Impairment and Dementia (VCID)

血管性认知障碍和痴呆 (VCID) 中的脑小血管成像

• 批准号: 10745164
• 负责人: Xuejuan Jiang
• 金额: $ 248.77万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745164
• 关键词: 3-Dimensional; Acceleration; African American; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Asian; Asian Americans; Atrophic; Behavioral; Blood; Blood Vessels; Blood capillaries; Brain; Caucasians; Cerebral small vessel disease; Cerebrum; Clinical; Cognitive; Data; Dementia; Development; Diffusion; Early Intervention; Enrollment; Evaluation; Goals; Guidelines; Head; Image; Image Analysis; Imaging Device; Imaging technology; Knowledge; Lacunar Infarctions; Latinx; Lesion; Longitudinal cohort; Los Angeles; Magnetic Resonance Imaging; Maps; Mediating; Morphology; Motion; Neuropsychology; Participant; Pathway Analysis; Perforating Artery; Perfusion; Physics; Physiological; Population; Prevention; Protocols documentation; Public Health; Research; Research Priority; Resolution; Resources; Risk; Speed; Stroke; Surrogate Markers; Techniques; Testing; Three-dimensional analysis; Training; Visit; Visualization; aged; analysis pipeline; arterial spin labeling; arteriole; behavioral phenotyping; biomedical imaging; cerebral microbleeds; cerebrovascular; clinical diagnosis; cohort; deep learning algorithm; density; disease phenotype; executive function; health disparity; high risk; imaging biomarker; improved; in vivo imaging; longitudinal analysis; mild cognitive impairment; mixed dementia; multi-ethnic; multidisciplinary; novel; potential biomarker; racial diversity; recruit; symposium; vascular cognitive impairment and dementia; venule; white matter

Project Summary/Abstract Vascular contributions to cognitive impairment and dementia (VCID) is becoming increasingly recognized as an important cause of dementia. Cerebral small vessel disease (cSVD) is the most common vascular cause of dementia, a major contributor to mixed dementia, and the cause of about one fifth of all strokes worldwide. However, the underlying mechanisms of cSVD remain poorly understood. The large knowledge gap in cSVD is partly because cerebral small vessels, including arterioles, capillaries and venules, are inaccessible to existing in vivo imaging technologies. During the past few years, our group has spearheaded the development of a new high-resolution black-blood MRI technique for the visualization, segmentation and quantification of cerebral small vessels including lenticulostriate and superficial perforating arteries and venules. This technique offers an isotropic ~0.5mm spatial resolution, adequate flow suppression for small vessels due to the long echo train, and near whole-brain coverage in ~10min at clinical field strength of 3T. We further developed a comprehensive 3D analysis pipeline for quantifying the morphology and density of cerebral small vessels with sizes on the order of a few hundred microns. In addition, we have a longstanding track record in developing and applying arterial spin labeling (ASL) techniques for quantifying microvascular perfusion – a key physiological parameter and potential biomarker for cSVD. Our preliminary data demonstrated expected changes in small vessel morphology and density as well as microvascular perfusion with aging, vascular risks and mild cognitive impairment (MCI), supporting the use of metrics of small vessel morphology/density and microvascular perfusion as imaging markers of cSVD and VCID. The primary goals of this project are to further optimize the acquisition protocol and analysis pipeline for mapping and quantifying cerebral small vessels using black-blood and ASL MRI at 3T, and to systematically evaluate metrics of small vessel morphology/density and perfusion as imaging biomarkers of VCID in a multiethnic longitudinal cohort of 200 subjects that are enriched for small vessel VCID. In particular, our study will enroll a cohort of 50 Asian Americans who are among the fastest growing populations in the US but are highly underrepresented in ADRD research. This project is expected to result in a powerful suite of imaging tools for comprehensive characterization of the morphology and function of cerebral small vessels, as well as to fill in the important gap in health disparities of Asian Americans in ADRD research.

项目概要/摘要 人们越来越认识到血管对认知障碍和痴呆 (VCID) 的影响 痴呆的一个重要原因。脑小血管病（cSVD）是最常见的血管疾病 痴呆症是混合性痴呆症的主要原因，也是全世界约五分之一中风的原因。 然而，cSVD 的潜在机制仍然知之甚少。 CSVD 中巨大的知识差距是 部分原因是现有的脑小血管（包括小动脉、毛细血管和小静脉）无法进入 体内成像技术。在过去的几年里，我们集团率先开发了一种新的 高分辨率黑血 MRI 技术，用于大脑的可视化、分割和量化 小血管包括豆纹和浅表穿支动脉和小静脉。该技术提供了 各向同性 ~0.5mm 空间分辨率，由于长回波序列，对小血管有足够的流量抑制， 在 3T 临床场强下，约 10 分钟即可实现近乎全脑覆盖。我们进一步开发了 全面的 3D 分析流程，用于量化脑小血管的形态和密度 尺寸在几百微米的量级。此外，我们在开发方面拥有长期的记录 并应用动脉自旋标记 (ASL) 技术来量化微血管灌注——关键 cSVD 的生理参数和潜在生物标志物。我们的初步数据表明预期 小血管形态和密度的变化以及微血管灌注随衰老、血管风险的变化 和轻度认知障碍（MCI），支持使用小血管形态/密度和 微血管灌注作为 cSVD 和 VCID 的成像标志物。该项目的主要目标是进一步 优化用于绘制和量化脑小血管的采集协议和分析管道 使用 3T 黑血和 ASL MRI，系统地评估小血管的指标 在 200 名多种族纵向队列中，将形态/密度和灌注作为 VCID 的成像生物标志物 丰富了小血管 VCID 的受试者。特别是，我们的研究将招募 50 名亚洲人 属于美国人口增长最快但在 ADRD 中代表性严重不足的美国人 研究。该项目预计将产生一套强大的成像工具，用于全面的 表征脑小血管的形态和功能，并填补重要空白 ADRD 研究中亚裔美国人的健康差异。