Nociplastic mechanisms in somatic and visceral pain

躯体和内脏疼痛的伤害性机制

• 批准号: 10746147
• 负责人: Noah C. Waller
• 金额: $ 4.33万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10746147
• 关键词: Acoustic Stimulation; Address; Attention; Auditory; Biological; Bone Tissue; Brain; Brain imaging; Carpal Tunnel Syndrome; Central Nervous System; Characteristics; Data; Data Set; Degenerative polyarthritis; Development; Diagnosis; Diagnostic; Disparity; Economic Burden; Elements; Exhibits; Fatigue; Fibromyalgia; Foundations; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Goals; Gynecologic; Healthcare Systems; Heterogeneity; Hip Osteoarthritis; Hyperalgesia; Hypersensitivity; Hysterectomy; Individual; Insula of Reil; Interstitial Cystitis; Investigation; Knowledge; Label; Literature; Lower urinary tract; Measures; Mediating; Mentors; Methods; Mission; National Institute of Diabetes and Digestive and Kidney Diseases; Needs Assessment; Neurobiology; Nociception; Organ; Outcome; Outcome Measure; Overactive Bladder; Pain; Pain Disorder; Pain Free; Pain Research; Pain management; Painless; Participant; Patient Outcomes Assessments; Patients; Pelvic Pain; Peripheral; Phase; Phenotype; Photic Stimulation; Protocols documentation; Public Health; Reporting; Research; Research Activity; Research Personnel; Rest; Rheumatoid Arthritis; Sensory; Symptoms; Syndrome; Techniques; Testing; Time; United States National Institutes of Health; Viscera; Visceral; Visceral pain; Visual; Work; allodynia; analog; arthritic pain; career; central pain; central sensitization; chronic pain; chronic pain patient; chronic painful condition; chronic pelvic pain; cohort; fibromyalgia patients; imaging modality; improved; insight; interdisciplinary approach; multimodality; neural; neuroimaging; novel; osteoarthritis pain; pain perception; pain processing; poor sleep; response; social; soft tissue; somatosensory; tool; training opportunity; urologic; urologic chronic pelvic pain syndrome

PROJECT SUMMARY/ABSTRACT Chronic pain is a significant social and economic burden. Despite considerable progress over the last several decades of research, our understanding of the neurobiological underpinnings of chronic pain remains incomplete and this presents obstacles for improvement in pain management. Multimodal investigations into the mechanistic heterogeneity within and across chronic pain conditions are critical for the development of new and efficacious precision pain treatments. The central nervous system (CNS) governs the perception of pain. Sensitization of the CNS is a mechanism hypothesized to underly the increased pain and sensory sensitivity observed in patients with chronic pain. This mechanism is referred to as nociplastic pain. Quantitative sensory testing (QST), functional magnetic resonance imaging (fMRI), and patient-reported outcome measures (PROMs) are methods that can be used together to build multimodal profiles that characterize the degree and features of an individual’s nociplastic pain phenotype. The proposed F99 and K00 projects will use these methods to distinguish convergent and divergent nociplastic mechanisms across diagnostically distinct somatic (emanating from bones and soft tissue) and visceral (emanating from internal organs) chronic pain conditions. The overall objective for the proposed project is to identify shared and distinct nociplastic profiles between somatic and visceral pain conditions to ultimately stimulate the development of precision pain management tools. The goal of the F99 portion is to characterize sensory and neurobiological features of nociplastic pain in patients with somatic pain, including those with rheumatoid arthritis (RA), osteoarthritis (OA), and carpal tunnel syndrome (CTS), relative to healthy controls and patients with fibromyalgia – the archetypal nociplastic pain condition. This analysis will build a foundation for the long-term aim of this work’s K00 portion, where parallel sensory and neurobiological measures will be assessed in patients with visceral pain, including those with urologic chronic pelvic pain syndrome (UCPPS), overactive bladder (OAB), and gynecological chronic pelvic pain (CPP). Data from the NIDDK-funded Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network and Lower Urinary Tract Dysfunction Research Network (LURN) will be leveraged to complete the K00 project. Together, the mentoring and research activities of this F99 and K00 work will establish a career trajectory for me to become an independent researcher with expertise in urological pain.

项目摘要/摘要 慢性疼痛是一个重大的社会和经济负担。尽管最近几个进展取得了长足的进步 数十年的研究，我们对慢性疼痛的神经生物学基础的理解仍然存在 不完整，这给改善疼痛管理带来了障碍。多模式调查 慢性疼痛状况内部和跨性别的机械异质性对于新的发展至关重要 和有效的精度疼痛治疗。 中枢神经系统（CNS）控制着疼痛的感知。中枢神经系统的敏化是一种机制 假设在慢性疼痛患者中观察到的疼痛和感觉敏感性的增加。这 机制称为Nociplast疼痛。定量感觉测试（QST），功能磁 共振成像（fMRI）和患者报告的结果指标（PROM）是可以使用的方法 共同构建多模式的轮廓，以表征个人的nociplastic的程度和特征 疼痛表型。拟议的F99和K00项目将使用这些方法来区分融合和 跨诊断不同的躯体（骨骼和软散发）的发散性致密机制 组织）和内脏（由内脏内部器发出）慢性疼痛条件。 拟议项目的总体目标是确定共享和独特的野性轮廓 躯体和内脏疼痛状况最终刺激精度疼痛管理的发展 工具。 F99部分的目的是表征鼻骨疼痛的感觉和神经生物学特征 体细胞疼痛的患者，包括类风湿关节炎（RA），骨关节炎（OA）和腕管患者 综合征（CTS），相对于健康对照组和纤维肌痛患者 - 原型润滑疼痛 健康）状况。该分析将为这项工作的K00部分的长期目标奠定基础 在内脏疼痛的患者中，将评估感觉和神经生物学措施，包括 泌尿科慢性骨盆疼痛综合征（UCPPS），过度活跃的膀胱（OAB）和妇科慢性骨盆 疼痛（CPP）。来自NIDDK资助的多学科方法的数据，用于研究慢性骨盆疼痛 （MAPP）研究网络和下尿路功能障碍研究网络（LURN）将被利用 完成K00项目。这项F99和K00工作的心理和研究活动一起将 为我建立职业轨迹，成为一名具有泌尿外科专业知识的独立研究人员。