UAB National Coordinating Center for the George M. O'Brien Kidney National Resource Centers

30多年来，国家糖尿病、消化和肾脏疾病研究所(NIDDK)一直在资助 奥布莱恩肾脏中心计划，以促进肾脏相关研究。扩大…的广度和影响 在这些中心，NIDDK通过建立O‘Brien肾脏联盟修改了这一计划。这 财团将包括约8个以主题为基础的国家资源中心(NRCS)，任务是开发和 共享专业资源、工具、技术、服务和专业知识以及国家协调中心 (NCC)领导、管理和协调财团的所有方面。我们建议将这所大学 阿拉巴马州伯明翰(UAB)担任O‘Brien肾脏财团的NCC。由An领导 流行病学家(保罗·蒙特纳博士)和肾病学家(奥兰多·古铁雷斯博士)，并得到肾病学家的支持， 生物统计学家、肾脏生理学家、健康行为学家和强大的研究导师，建议的NCC 调查团队是跨学科的，有参与NIDDK赞助的财团的经验。UAB拥有 领导NCC的基础设施，包括(1)已建立的数据管理和分析中心(DMAC) 已建立数据门户，支持NIH资助的多中心网络并实施 增强协作、通用数据元素和数据共享的计划，以及(2)体验 患者确保研究解决对他们来说重要的问题，(3)致力于多样性/公平/ 包容性；(4)药物开发/创业方面的专门知识，以促进将研究转化为更好的 患者结果，以及(4)将为早期调查人员提供支持的培训计划，以刺激 他们的研究的创新和影响。此外，UAB调查人员已经实施了 管理的竞争性试点赠款计划促进了发展，并提供了支持的高 以可观的投资回报影响研究思路。UAB NCC有五个目标，包括(1) 提供行政支持，促进沟通和协调，并通过以下方式增强协同 执行奥布莱恩财团的标准操作程序和小组委员会；(2)扩大 UAB DMAC为O‘Brien提供共享协议、数据、工具和其他资源的门户 (3)实施培训计划，其中包括团队科学研讨会、分级、同行和 近乎同行的指导，以及让早期调查人员与奥布莱恩合作的虚拟办公时间 NRCS；(4)通过焦点小组和活跃的科学家参与患者的观点、优先事项和偏好- 患者互动，告知O‘Brien NRCS和财团；以及(5)实施国家试点计划 通过提交前的科学和生物统计咨询、严格的同行审查和持续的指导 支持早期研究人员、肾脏研究新手以及与更广泛的 肾脏社区。UAB NCC将支持NIDDK和O‘Brien肾脏财团推进肾脏 在全国范围内进行研究，最大限度地提高肾脏健康的影响。

For over 30 years, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) has funded the O’Brien Kidney Center program to advance kidney-related research. To expand the breadth and impact of these centers, NIDDK has modified this program by establishing the O’Brien Kidney Consortium. This consortium will include ~8 theme-based National Resource Centers (NRCs) tasked with developing and sharing specialized resources, tools, technologies, services, and expertise and a National Coordinating Center (NCC) to lead, manage, and harmonize all aspects of the Consortium. We propose the University of Alabama at Birmingham (UAB) to serve as the NCC for the O’Brien Kidney Consortium. Led by an epidemiologist (Dr. Paul Muntner) and nephrologist (Dr. Orlando Gutiérrez) and supported by nephrologists, biostatisticians, kidney physiologists, health behaviorists, and strong research mentors, the proposed NCC investigator team is interdisciplinary with experience participating in NIDDK-sponsored consortia. UAB has the infrastructure to lead the NCC including (1) An established Data Management and Analysis Center (DMAC) with an established data portal that has supported NIH-funded multi-center networks and implemented programs to enhance collaboration, common data elements, and data sharing, and (2) Experience engaging patients to ensure research addresses issues that are important to them, (3) A commitment to diversity/equity/ inclusion, (4) Drug development/ entrepreneurship expertise to facilitate the translation of research into better patient outcomes, and (4) Training programs that will provide support for early-stage investigators that spurs innovation and impact of their research. Additionally, the UAB investigators have implemented and administered competitive pilot grant programs that has nurtured the development and provided supported high- impact research ideas with a substantial return on investment. The UAB NCC has five aims including (1) Providing administrative support, facilitating communication and coordination, and enhancing synergy by implementing standard operating procedures and sub-committees for the O’Brien consortium; (2) Expanding the UAB DMAC to provide a portal for sharing protocols, data, tools and other resources for the O’Brien consortium; (3) Implementing a training plan that includes team science workshops, hierarchical, peer and near-peer mentoring, and virtual office hours for early-stages investigators to collaborate with the O’Brien NRCs; (4) Engaging patient viewpoints, priorities and preferences through focus groups and active scientist- patient interaction to inform the O’Brien NRCs and consortium; and (5) Administering a national pilot program with pre-submission scientific and biostatistics consultation, rigorous peer review, and ongoing mentorship to support early-stage investigators, investigators new to kidney research and collaborations with the broader kidney community. The UAB NCC will support NIDDK and the O’Brien Kidney Consortium to advance kidney research nationwide maximizing the impact on improving kidney health.