UAB National Coordinating Center for the George M. O'Brien Kidney National Resource Centers

阿拉巴马大学乔治·M·奥布莱恩肾脏国家资源中心国家协调中心

基本信息

项目摘要

For over 30 years, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) has funded the O’Brien Kidney Center program to advance kidney-related research. To expand the breadth and impact of these centers, NIDDK has modified this program by establishing the O’Brien Kidney Consortium. This consortium will include ~8 theme-based National Resource Centers (NRCs) tasked with developing and sharing specialized resources, tools, technologies, services, and expertise and a National Coordinating Center (NCC) to lead, manage, and harmonize all aspects of the Consortium. We propose the University of Alabama at Birmingham (UAB) to serve as the NCC for the O’Brien Kidney Consortium. Led by an epidemiologist (Dr. Paul Muntner) and nephrologist (Dr. Orlando Gutiérrez) and supported by nephrologists, biostatisticians, kidney physiologists, health behaviorists, and strong research mentors, the proposed NCC investigator team is interdisciplinary with experience participating in NIDDK-sponsored consortia. UAB has the infrastructure to lead the NCC including (1) An established Data Management and Analysis Center (DMAC) with an established data portal that has supported NIH-funded multi-center networks and implemented programs to enhance collaboration, common data elements, and data sharing, and (2) Experience engaging patients to ensure research addresses issues that are important to them, (3) A commitment to diversity/equity/ inclusion, (4) Drug development/ entrepreneurship expertise to facilitate the translation of research into better patient outcomes, and (4) Training programs that will provide support for early-stage investigators that spurs innovation and impact of their research. Additionally, the UAB investigators have implemented and administered competitive pilot grant programs that has nurtured the development and provided supported high- impact research ideas with a substantial return on investment. The UAB NCC has five aims including (1) Providing administrative support, facilitating communication and coordination, and enhancing synergy by implementing standard operating procedures and sub-committees for the O’Brien consortium; (2) Expanding the UAB DMAC to provide a portal for sharing protocols, data, tools and other resources for the O’Brien consortium; (3) Implementing a training plan that includes team science workshops, hierarchical, peer and near-peer mentoring, and virtual office hours for early-stages investigators to collaborate with the O’Brien NRCs; (4) Engaging patient viewpoints, priorities and preferences through focus groups and active scientist- patient interaction to inform the O’Brien NRCs and consortium; and (5) Administering a national pilot program with pre-submission scientific and biostatistics consultation, rigorous peer review, and ongoing mentorship to support early-stage investigators, investigators new to kidney research and collaborations with the broader kidney community. The UAB NCC will support NIDDK and the O’Brien Kidney Consortium to advance kidney research nationwide maximizing the impact on improving kidney health.
30多年来,国家糖尿病、消化和肾脏疾病研究所(NIDDK)一直资助 奥布莱恩肾脏中心计划推进肾脏相关研究。扩大的广度和影响, NIDDK通过建立奥布莱恩肾脏联盟来修改该计划。这 该联盟将包括约8个基于主题的国家资源中心(NRC),其任务是开发和 共享专业资源、工具、技术、服务和专业知识,以及国家协调中心 (NCC)领导、管理和协调联合体的各个方面。我们建议大学 亚拉巴马在伯明翰(UAB)作为NCC的奥布莱恩肾脏财团。前面的是一头 流行病学家(Paul Muntner博士)和肾病学家(Orlando Gutiérrez博士),并得到肾病学家的支持, 生物统计学家,肾脏生理学家,健康行为学家和强大的研究导师,拟议的NCC 研究小组是跨学科,有参加NIDDK赞助财团的经验。UAB拥有 领导NCC的基础设施包括:(1)建立数据管理和分析中心(DMAC) 拥有一个已建立的数据门户,该门户支持NIH资助的多中心网络, 增强协作、公共数据元素和数据共享的计划,以及(2)吸引人的经验 患者,以确保研究解决的问题是重要的,他们(3)对多样性/公平性的承诺, (4)药物开发/创业专门知识,以促进将研究成果转化为更好的 患者结局,以及(4)培训计划,为早期研究者提供支持, 他们的研究的创新和影响。此外,UAB调查人员已经实施并 管理有竞争力的试点赠款计划,培育了发展,并提供了支持高, 以可观的投资回报影响研究想法。UAB NCC有五个目标,包括(1) 提供行政支持,促进沟通和协调,并通过以下方式加强协同作用: 实施奥布莱恩财团的标准操作程序和小组委员会;(2)扩大 UAB DMAC为奥布莱恩提供共享协议、数据、工具和其他资源的门户 (3)实施培训计划,包括团队科学研讨会,分层,同行和 近同行指导,以及早期调查人员与奥布莱恩合作的虚拟办公时间 (4)通过焦点小组和活跃的科学家,让患者参与到观点、优先事项和偏好中来- 患者互动,告知奥布莱恩NRC和财团;(5)管理国家试点项目 通过提交前的科学和生物统计咨询,严格的同行评审和持续的指导, 支持早期研究者,肾脏研究的新研究者以及与更广泛的合作者 肾脏社区。UAB NCC将支持NIDDK和奥布莱恩肾脏联盟, 在全国范围内进行研究,最大限度地提高对改善肾脏健康的影响。

项目成果

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Amanda Hyre Anderson其他文献

Amanda Hyre Anderson的其他文献

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{{ truncateString('Amanda Hyre Anderson', 18)}}的其他基金

The Gut Microbiome and The Metabolome in Chronic Kidney Disease
慢性肾脏病的肠道微生物组和代谢组
  • 批准号:
    9353782
  • 财政年份:
    2016
  • 资助金额:
    $ 119.33万
  • 项目类别:
The Gut Microbiome and The Metabolome in Chronic Kidney Disease
慢性肾脏病的肠道微生物组和代谢组
  • 批准号:
    9980882
  • 财政年份:
    2016
  • 资助金额:
    $ 119.33万
  • 项目类别:
The Gut Microbiome and The Metabolome in Chronic Kidney Disease
慢性肾脏病的肠道微生物组和代谢组
  • 批准号:
    9176606
  • 财政年份:
    2016
  • 资助金额:
    $ 119.33万
  • 项目类别:
Measures of Fibrosis and Clinical Outcomes in Chronic Kidney Disease
慢性肾脏病纤维化和临床结果的测量
  • 批准号:
    9259967
  • 财政年份:
    2015
  • 资助金额:
    $ 119.33万
  • 项目类别:
Modifiable and Biochemical Predictors and Consequences of Acute Kidney Injury
急性肾损伤的可修改和生化预测因子及后果
  • 批准号:
    8302359
  • 财政年份:
    2011
  • 资助金额:
    $ 119.33万
  • 项目类别:
Modifiable and Biochemical Predictors and Consequences of Acute Kidney Injury
急性肾损伤的可修改和生化预测因子及后果
  • 批准号:
    8469031
  • 财政年份:
    2011
  • 资助金额:
    $ 119.33万
  • 项目类别:
Modifiable and Biochemical Predictors and Consequences of Acute Kidney Injury
急性肾损伤的可修改和生化预测因子及后果
  • 批准号:
    8853856
  • 财政年份:
    2011
  • 资助金额:
    $ 119.33万
  • 项目类别:
Modifiable and Biochemical Predictors and Consequences of Acute Kidney Injury
急性肾损伤的可修改和生化预测因子及后果
  • 批准号:
    8165479
  • 财政年份:
    2011
  • 资助金额:
    $ 119.33万
  • 项目类别:
Modifiable and Biochemical Predictors and Consequences of Acute Kidney Injury
急性肾损伤的可修改和生化预测因子及后果
  • 批准号:
    8666747
  • 财政年份:
    2011
  • 资助金额:
    $ 119.33万
  • 项目类别:
Continuation of the Chronic Renal Insufficiency Cohort (CRIC)
慢性肾功能不全队列 (CRIC) 的延续
  • 批准号:
    10730902
  • 财政年份:
    2001
  • 资助金额:
    $ 119.33万
  • 项目类别:
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