UAB National Coordinating Center for the George M. O'Brien Kidney National Resource Centers

阿拉巴马大学乔治·M·奥布莱恩肾脏国家资源中心国家协调中心

• 批准号: 10747181
• 负责人: Amanda Hyre Anderson
• 金额: $ 119.33万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10747181
• 关键词: Accountability; Acute Renal Failure with Renal Papillary Necrosis; Address; Alabama; Applications Grants; Area; Biometry; Caring; Chronic Kidney Failure; Clinical and Translational Science Awards; Collaborations; Common Data Element; Communication; Communities; Consultations; Data; Data Analyses; Development; Educational workshop; Ensure; Entrepreneurship; Epidemiologist; Faculty; Feedback; Focus Groups; Funding; Goals; Grant; Health; High Prevalence; Hour; Incidence; Individual; Infrastructure; Institution; Investments; Kidney; Kidney Diseases; Lead; Mentors; Mentorship; National Institute of Diabetes and Digestive and Kidney Diseases; Outcome; Output; Pathway interactions; Patient-Focused Outcomes; Patients; Peer Review; Pilot Projects; Play; Procedures; Productivity; Protocols documentation; Published Comment; Research; Research Personnel; Research Priority; Resource Sharing; Resources; Role; Science; Scientist; Services; Societies; Students; Technology; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Vision; Writing; data management; data portal; data sharing; data standards; drug development; education planning; equity, diversity, and inclusion; experience; improved; improved outcome; innovation; meetings; operation; outreach; patient engagement; patient oriented; peer; peer coaching; preference; prevent; programs; success; synergism; tool; virtual

For over 30 years, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) has funded the O’Brien Kidney Center program to advance kidney-related research. To expand the breadth and impact of these centers, NIDDK has modified this program by establishing the O’Brien Kidney Consortium. This consortium will include ~8 theme-based National Resource Centers (NRCs) tasked with developing and sharing specialized resources, tools, technologies, services, and expertise and a National Coordinating Center (NCC) to lead, manage, and harmonize all aspects of the Consortium. We propose the University of Alabama at Birmingham (UAB) to serve as the NCC for the O’Brien Kidney Consortium. Led by an epidemiologist (Dr. Paul Muntner) and nephrologist (Dr. Orlando Gutiérrez) and supported by nephrologists, biostatisticians, kidney physiologists, health behaviorists, and strong research mentors, the proposed NCC investigator team is interdisciplinary with experience participating in NIDDK-sponsored consortia. UAB has the infrastructure to lead the NCC including (1) An established Data Management and Analysis Center (DMAC) with an established data portal that has supported NIH-funded multi-center networks and implemented programs to enhance collaboration, common data elements, and data sharing, and (2) Experience engaging patients to ensure research addresses issues that are important to them, (3) A commitment to diversity/equity/ inclusion, (4) Drug development/ entrepreneurship expertise to facilitate the translation of research into better patient outcomes, and (4) Training programs that will provide support for early-stage investigators that spurs innovation and impact of their research. Additionally, the UAB investigators have implemented and administered competitive pilot grant programs that has nurtured the development and provided supported high- impact research ideas with a substantial return on investment. The UAB NCC has five aims including (1) Providing administrative support, facilitating communication and coordination, and enhancing synergy by implementing standard operating procedures and sub-committees for the O’Brien consortium; (2) Expanding the UAB DMAC to provide a portal for sharing protocols, data, tools and other resources for the O’Brien consortium; (3) Implementing a training plan that includes team science workshops, hierarchical, peer and near-peer mentoring, and virtual office hours for early-stages investigators to collaborate with the O’Brien NRCs; (4) Engaging patient viewpoints, priorities and preferences through focus groups and active scientist- patient interaction to inform the O’Brien NRCs and consortium; and (5) Administering a national pilot program with pre-submission scientific and biostatistics consultation, rigorous peer review, and ongoing mentorship to support early-stage investigators, investigators new to kidney research and collaborations with the broader kidney community. The UAB NCC will support NIDDK and the O’Brien Kidney Consortium to advance kidney research nationwide maximizing the impact on improving kidney health.

30多年来，美国国家糖尿病与消化和肾脏疾病（NIDDK）已资助 奥布莱恩肾脏中心计划，以推进与肾脏有关的研究。扩大广度和影响 这些中心NIDDK通过建立O'Brien肾脏财团来修改该计划。 财团将包括约8个基于主题的国家资源中心（NRC），负责开发和 共享专业资源，工具，技术，服务和专业知识以及国家协调中心 （NCC）领导，管理和协调财团的各个方面。我们建议大学 伯明翰（UAB）的阿拉巴马州担任奥布莱恩肾脏财团的NCC。由an 流行病学家（Paul Muntner博士）和肾脏科医生（OrlandoGutiérrez博士），并得到了肾脏科医生的支持 拟议的NCC提议 调查员团队正在跨学科，并参加了参加NIDDK赞助的财团的经验。 UAB有 基础架构领导NCC，包括（1）已建立的数据管理和分析中心（DMAC） 拥有已建立的数据门户，该门户网站支持NIH资助的多中心网络并实施 增强协作，共同数据元素和数据共享的计划，以及（2）参与的经验 确保研究解决对他们重要的问题的患者，（3）对多样性/权益/的承诺 包容性，（4）药物开发/企业家精神专业知识，以促进研究转化为更好 患者成果和（4）将为刺激的早期调查人员提供支持的培训计划 他们的研究的创新和影响。此外，UAB调查人员已经实施， 管理竞争性的试点赠款计划，该计划已经护理了这一发展，并提供了支持的高级试点计划 影响研究思想，并具有可观的投资回报。 UAB NCC有五个目标，包括（1） 提供行政支持，支持沟通和协调，并通过 实施奥布莱恩联盟的标准操作程序和小组委员会； （2）扩展 UAB DMAC为O'Brien提供共享协议，数据，工具和其他资源的门户网站 财团； （3）实施一个培训计划，其中包括团队科学研讨会，等级制，同行和 近近期的心理和虚拟办公时间，以供早期阶段调查人员与O’Brien合作 NRCS; （4）通过焦点小组和活跃的科学家参与患者的观点，优先级和偏好 - 患者互动以告知O'Brien NRC和财团； （5）管理国家试点计划 通过接受前的科学和生物统计学咨询，严格的同伴审查以及持续的心态 支持早期的调查人员，肾脏研究新手的调查人员以及与更广泛的合作 肾脏社区。 UAB NCC将支持NIDDK和O'Brien肾脏财团推进肾脏 全国研究最大化对改善肾脏健康的影响。